Molecular Biophysics Faculty and Research
Program faculty have diverse backgrounds and interests, ranging from mathematics and theoretical physics to neurobiology and genetics.
Research in the program is highly interdisciplinary, comprising faculty drawn from the departments of Biophysics, Pharmacology, Physiology, Cell Biology, Systems Biology, Neuroscience, Radiology, Obstetrics and Gynecology, and others. A list of program faculty with their research interests is given below.
Dominika Borek, Ph.D.
Research Interests: Eukaryotic chromatin organization, mutational rates and spectra, biological signals and noise
Chad Brautigam, Ph.D.
Research Interests: Basic processes in living organisms at atomic level, using X-ray crystallography, analytical ultracentrifugation, isothermal titration calorimetry, and other biophysical techniques
Min Chen, Ph.D.
Research Interests: Statistical and computational methods for problems in molecular biology and genetics; research topics include microarray, GWAS, next generation sequencing, pathway-based genomics analysis, and eQTL
Zhe Chen, Ph.D.
Research Interests: Structural and functional studies of proteins in signal transduction
Khuloud Jaqaman, Ph.D.
Research Interests: Quantitative single-molecule imaging of receptor organization and signaling; linking molecular and cellular behavior across multiple scales; computational image analysis and data multiplexing
Qiu-Xing Jiang, Ph.D.
Research Interests: Structure and function of large membrane assemblies, including ion channels and transporters using electron cryo-microscopy and crystallographic analysis to generate 3D structures and perform functional studies in in vitro or in vivo systems
Xin Liu, Ph.D.
Research Interests: Roles of chromatin and nuclear organization in transcriptional regulation; structural and biochemical studies of chromatin dynamics during transcriptional activation and repression.
Xuelian (Sue) Luo, Ph.D.
Research Interests: Protein structure determination by Nuclear Magnetic Resonance (NMR); protein folding; cell cycle checkpoints and cancer
Craig R. Malloy, M.D.
Research Interests: The analysis of metabolism in intact tissues by NMR spectroscopy; development of new methods to understand metabolic processes in functioning cells
Ralph P. Mason, Ph.D.
Research Interests: Development of novel techniques for prognostic radiology with emphasis on tumor oxygenation, pH and efficacy of gene therapy; nuclear magnetic resonance, bioluminescence, PET and SPECT
Matthew Merritt, Ph.D.
Research Interests: Understanding metabolic flux in living systems using stable isotope tracer technology. In addition, development of hardware for Dynamic Nuclear Polarization, a method for enhancing magnetic resonance signals by factors of 10000 or greater.
Margaret A. (Meg) Phillips, Ph.D.
Research Interests: Polyamine and pyrimidine metabolism in trypanosome and malaria parasites
Arun Radhakrishnan, Ph.D.
Research Interests: Understanding how protein sensors measure levels of cholesterol in cell membranes.
Luke Rice, Ph.D.
Research Interests: Integrating structure, kinetics, and computation to understand the molecular determinants and regulatory mechanisms of microtubule dynamics
Elliott Ross, Ph.D.
Research Interests: Mechanisms of G-protein signaling; amplification, selectivity, response timing; structure/function of GTPase-activating proteins and associated receptors
William Russ, Ph.D.
Research Interests: Evolutionary principles of enzyme design
Diana R. Tomchick, Ph.D.
Research Interests: Basic processes in living organisms at atomic level using X-ray crystallography, NMR spectroscopy and other biophysical techniques
E. Sally Ward, Ph.D.
Research Interests: Antibody engineering; fluorescence microscopy; Fc receptor and growth factor receptor trafficking; development of therapies for cancer and autoimmunity
Guanghua (Andy) Xiao, Ph.D.
Research Interests: Statistical methods for genomics/proteomics and in spatial/image analysis
Yang Xie, Ph.D.
Research Interests: Processing and analysis of high throughput data; false discovery rate estimation; integrated analysis methodology; Bayesian analysis methodology; design and analysis of clinical trials
Xuewu Zhang, Ph.D.
Research Interests: Biochemical and Structural studies of regulation mechanisms for signaling proteins, especially receptor-mediated signaling pathways in neuron development and axonal guidance