Molecular Biophysics Faculty and Research
Program faculty have diverse backgrounds and interests, ranging from mathematics and theoretical physics to neurobiology and genetics.
Research in the Molecular Biophysics Graduate Program is highly interdisciplinary, comprising faculty drawn from the departments of Biophysics, Pharmacology, Physiology, Cell Biology, Neuroscience, Radiology, Obstetrics and Gynecology, and others. A list of faculty with their research interests is given below.
William Henne, Ph.D.
Research Interests: Molecular Mechanisms of Membrane Sculpting; formation and dynamics of inter-organelle membrane contact sites (MCSs) in human health and disease
Ryan Hibbs, Ph.D.
Research Interests: Ion channel structure-function, membrane protein structural biology
Khuloud Jaqaman, Ph.D.
Research Interests: Quantitative single-molecule imaging of receptor organization and signaling; linking molecular and cellular behavior across multiple scales; computational image analysis and data multiplexing
Qiu-Xing Jiang, Ph.D.
Research Interests: Structure and function of large membrane assemblies, including ion channels and transporters using electron cryo-microscopy and crystallographic analysis to generate 3D structures and perform functional studies in in vitro or& in vivo systems
Xin Liu, Ph.D.
Research Interests: Roles of chromatin and nuclear organization in transcriptional regulation; structural and biochemical studies of chromatin dynamics during transcriptional activation and repression.
Xuelian (Sue) Luo, Ph.D.
Research Interests: Protein structure determination by nuclear magnetic resonance (NMR); protein folding; cell cycle checkpoints and cancer
Ralph P. Mason, Ph.D.
Research Interests: Development of novel techniques for prognostic radiology with emphasis on tumor oxygenation, pH, and efficacy of gene therapy; nuclear magnetic resonance, bioluminescence, PET and SPECT
Matthew Merritt, Ph.D.
Research Interests: Understanding metabolic flux in living systems using stable isotope tracer technology. In addition, development of hardware for Dynamic Nuclear Polarization, a method for enhancing magnetic resonance signals by factors of 10000 or greater.
Michael Reese, Ph.D.
Research Interests: Biochemistry; Biophysics; Cell signaling, kinases, pseudokinases; Host-pathogen interaction; co-evolution; Immunology; Structural biology
Kimberly Reynolds, Ph.D.
Research Interests: Statistical analysis and rational design of cellular systems
Luke Rice, Ph.D.
Research Interests: Integrating structure, kinetics, and computation to understand the molecular determinants and regulatory mechanisms of microtubule dynamics
Michael K. Rosen, Ph.D.
Research Interests: Structural, biochemical, and cell biological mechanisms of signal transduction that control the actin cytoskeleton
Elliott Ross, Ph.D.
Research Interests: Mechanisms of G-protein signaling; amplification, selectivity, response timing; structure/function of GTPase-activating proteins and associated receptors
Sandra Schmid, Ph.D.
Research Interests: Mechanisms governing and regulation of clathrin-mediated endocytosis, structure and function of the GTPase dynamin
Yang Xie, Ph.D.
Research Interests: Processing and analysis of high throughput data; false discovery rate estimation; integrated analysis methodology; Bayesian analysis methodology; design and analysis of clinical trials
Hong Zhang, Ph.D.
Research Interests: Structural enzymology; NAD biosynthesis and regulation; structure-based drug design
Xuewu Zhang, Ph.D.
Research Interests: Biochemical and Structural studies of regulation mechanisms for signaling proteins, especially receptor-mediated signaling pathways in neuron development and axonal guidance
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.
Dominika Borek, Ph.D.
Research Interests: Eukaryotic chromatin organization, mutational rates and spectra, biological signals and noise
Chad Brautigam, Ph.D.
Research Interests: Basic processes in living organisms at atomic level, using X-ray crystallography, analytical ultracentrifugation, isothermal titration calorimetry, and other biophysical techniques
Diana R. Tomchick, Ph.D.
Research Interests: Basic processes in living organisms at atomic level using X-ray crystallography, NMR spectroscopy, and other biophysical techniques