Genetics, Development and Disease Faculty

Faculty

John M.  Abrams, Ph.D.
Program Chair
Professor
Abrams Lab
Research Interests: Molecular genetics of cell death; genomic “dark matter”; p53 tumor suppressor function; 3D genome organization


Massimo Attanasio, M.D.
Assistant Professor


Xiaoying Bai, M.D., Ph.D.
Assistant Professor
Research Interests: Transcriptional regulation of hematopoietic stem cell fate


Linda Baker, M.D. 
Professor
Baker Lab 
Research Interests: Molecular mechanisms of normal genitourinary development and congenital birth defects


James Brugarolas, M.D., Ph.D.
Associate Professor
Brugarolas Lab
Research Interests: Molecular mechanisms of cell growth proliferation control


Sandeep Burma, Ph.D.
Associate Professor
Burma Lab
Research Interests: DNA double-strand break sensing, signaling and repair: from mechanistic understanding to glioblastoma therapy


Ezra Burstein, M.D.
Associate Professor
Burstein Lab
Research Interests: Molecular control of inflammatory responses in the intestine, inflammation and cancer progression, regulation of NF-kB activity, COMM.D. proteins


Michael Buszczak, Ph.D.
Associate Professor
Buszczak Lab
Research Interests: Stem cell biology; niche signaling; chromatin; translational repression


Thomas Carroll, Ph.D.
Associate Professor
Carroll Lab
Research Interests: Molecular mechanisms regulating kidney tubule formation and maintenance


Zhijian James Chen, Ph.D.
Professor
Chen Lab
Research Interests: NF-B signaling and the ubiquitin-proteasome pathway


Ondine Cleaver, Ph.D.
Associate Professor
Cleaver Lab
Research Interests: Molecular mechanisms of cell fate specification during blood vessel development and organogenesis


Jonathan Cohen, Ph.D.
Professor
Hobbs/Cohen Lab
Research Interests: Genetics of quantitative traits; genetic determinants of plasma lipoprotein levels


James Collins, Ph.D.
Assistant Professor
Collins Lab 
Research Interests:


Ralph J. DeBerardinis, M.D., Ph.D.
Associate Professor
DeBerardinis Lab
Research Interests: Regulation of metabolism during cell growth and tumorigenesis; integrating signal transduction with metabolic flux; understanding pediatric metabolic diseases


Michael Dellinger, Ph.D.
Assistant Professor 
Research Interests: 


Rene L. Galindo, M.D., Ph.D.
Assistant Professor
Galindo Lab
Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning


Christine Kim Garcia, M.D., Ph.D.
Associate Professor
Garcia Lab
Research Interests: Pulmonary medicine; human genetics; molecular genetics


Joseph Garcia, M.D., Ph.D. 
Associate Professor
Research Interests: Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia


William T. Garrard, Ph.D.
Professor
Research Interests: Regulation of immunoglobulin gene expression during B-cell development; chromatin structure-function relationships; regulation of the terminal stages of apoptosis


Robert Gerard, Ph.D.
Associate Professor
Gerard Lab
Research Interests: Specific research projects in my lab focus on in vivo tumor targeting using recombinant protein and adenoviral vector technology. Peptide ligands and monoclonal antibodies, as well as new technologies, are used as proven methods of targeting tumors for molecular imaging and therapy.


Jonathan M.  Graff, M.D., Ph.D.
Professor
Graff Lab
Research Interests: Signaling pathways in development and cancer


Rana Gupta, Ph.D.
Assistant Professor
Gupta Lab
Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease.


Robert E. Hammer, Ph.D.
Professor
Research Interests: Transforming growth factor beta signaling


F. Kent Hamra, Ph.D.
Assistant Professor
Hamra Lab
Research Interests: Sperm stem cell development; application of sperm stem cells in functional genomics; targeting sperm cell biology for fertility management and regenerative medicine 


Mark Henkemeyer, Ph.D.
Professor
Henkemeyer Lab 
Research Interests: Molecular genetics of axon guidance and brain development; bidirectional tyrosine kinase signaling


Helen H. Hobbs, M.D.
Professor
Hobbs/Cohen Lab
Research Interests: Identification of genetic factors contributing to inter-individual differences in the concentration of lipoproteins in the blood


Jenny Hsieh, Ph.D.
Associate Professor
Hsieh Lab
Research Interests: Stem cell biology; neurogenesis and gliogenesis in CNS; chromatin remodeling; neurological diseases


Lily Huang, Ph.D.
Assistant Professor
Huang Lab 
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer


Peter Igarashi, M.D.
Professor
Igarashi Lab
Research Interests: Transcriptional control of tissue-specific gene expression and organogenesis; polycystic kidney disease


Huaqi Jiang, Ph.D.
Assistant Professor
H. Jiang Lab
Research Interests: Regulation of tissue homeostasis and regeneration mediated by stem cells


Jin Jiang, Ph.D.
Professor
J. Jiang Lab
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes


Jane E. Johnson, Ph.D.
Professor
Johnson Lab  
Research Interests: Development of the mammalian nervous system; transcriptional regulation of neural cell-type specification


Tae-Kyung Kim, Ph.D.
Assistant Professor
Kim Lab
Research Interests: Genetic and epigenetic programs underlying brain development and function


Helmut Kramer, Ph.D.
Professor
Kramer Lab
Research Interests: Molecular genetics endosomal trafficking in Drosophila


W. Lee Kraus, Ph.D.
Professor
Kraus Lab
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus; biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation


Bing Li, Ph.D.
Professor
Li Lab
Research Interests: Chromatin regulation and eukaryotic transcription


Rueyling Lin, Ph.D.
Professor
Lin Lab
Research Interests: Cell-fate specification in Caenorhabditis elegans early development


Yi Liu, Ph.D.
Professor
Liu Lab
Research Interests: Molecular mechanisms of circadian biological clocks


Zhi-Ping Liu, Ph.D.
Associate Professor
Zhi-Ping Liu Lab
Research Interests: Elucidate transcriptional regulatory mechanisms of genes involved in cardiovascular diseases and characterize the signaling pathways coupling these transcriptional programs to extracellular signals that trigger this disease


Lawrence Lum, Ph.D.
Associate Professor
Lum Lab
Research Interests: How information from multiple signaling molecules, including Hh and Wg, integrate in developmental and disease-related contexts


Raymond J. MacDonald, Ph.D.
Professor
Research Interests: Transcriptional control of organogenesis


Joshua Mendell, M.D., Ph.D.
Professor 
Mendell Lab
Research Interests: Regulation and function of mammalian miRNAs and other noncoding RNAs in normal physiology and disease


Sean Morrison, Ph.D.
Professor
Morrison Lab
Research Interests: Cancer stem cell biology; Melanoma cell proliferation and metastasis; Stem cell aging; Stem cell self-renewal


Saikat Mukhopadhyay, M.D., Ph.D.
Assistant Professor 
Mukhopadhyay Lab
Research Interests: Role of the primary cilia in normal development and cancer, Functional proteomics in ciliary diseases, Ciliary signaling pathways


Nikhil Munshi, M.D., Ph.D.
Assistant Professor
Munshi Lab
Research Interests: Transcriptional mechanisms that orchestrate formation and function of the cardiac conduction system.


Kathryn A. O'Donnell, Ph.D.
Assistant Professor
O'Donnell-Mendell Lab
Research Interests: Identification and characterization of cancer-associated genes using transposon-mediated mutagenesis


Eric N. Olson, Ph.D.
Professor
Olson Lab
Research Interests: Transcriptional control of cell differentiation; muscle development


Luis Parada, Ph.D.
Professor
Parada Lab
Research Interests: The role of proto-oncogenes in vertebrate development; TRK receptors and neurotropins


Hesham Sadek, M.D., Ph.D.
Assistant Professor
Sadek Lab
Research Interests: Metabolic profiling of stem cells


Jay Schneider, M.D., Ph.D.
Associate Professor
Research Interests: Stem Cells, Cancer, microRNAs, small molecules


Jerry W. Shay, Ph.D.
Professor
Shay Lab
Research Interests: Defining the molecular mechanisms of human cell immortalization; telomeres and telomerase in aging and cancer


Stephen Skapek, M.D.
Professor 
Skapek Lab
Research Interests: Tumor suppressor gene function; Angiogenesis; Skeletal muscle differentiation; Oncogene-induced senescence


William J. Snell, Ph.D.
Professor
Snell Lab
Research Interests: Understanding the mechanisms of cell-cell adhesion induced signaling and cell-cell fusion during fertilization


Zhigao Wang, Ph.D.
Assistant Professor
Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death.


Tom Wilkie, Ph.D.
Associate Professor
Wilkie Lab
Research Interests: G-protein signaling during mouse development, energy homeostasis, and feeding behavior


Carol Wise, Ph.D.
Professor
Wise Lab
Research Interests: Genetics of pediatric musculoskeletal and autoinflammatory diseases


Woodring E. Wright, M.D., Ph.D.
Professor
Wright Lab
Research Interests: The role of telomeres and telomerase in cellular senescence and cancer; developing normal immortalized cells for therapeutic uses


Jiang Wu, Ph.D.
Assistant Professor
Wu Lab
Research Interests: Chromatin regulation of neural development; neural stem cell differentiation; activity dependent gene expression


Chao Xing, Ph.D.
Assistant Professor
Xing Lab
Research Interests: 


Jian Xu, Ph.D.
Assistant Professor
Research Interests: 


Hiromi Yanagisawa, M.D., Ph.D.
Associate Professor
Yanagisawa Lab 
Research Interests: Extracellular matrix proteins and maintenance of vessel microenvironment during development and disease; molecular mechanism of neural crest development in vivo


Chun-Li Zhang, Ph.D.
Associate Professor
Zhang Lab
Research Interests: Nuclear receptor signaling and adult neural stem cells


Hao Zhu, M.D.
Assistant Professor
Zhu Lab
Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer


Andrew R.  Zinn, M.D., Ph.D.
Professor
Zinn Lab
Research Interests: Genetic disorders of human growth and reproduction; Turner syndrome; infertility; obesity

Associate Members
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

Stuart Ravnik, Ph.D. 
Assistant Professor
Research Interests: Molecular control of germ-cell development and meiosis


Scott Robertson, Ph.D.
Assistant Professor
Research Interests: Lineage commitment from mesoderm; initiation of hematopoietic development