Genetics, Development and Disease Faculty

Faculty

John Abrams, Ph.D

John M. Abrams, Ph.D.
Program Chair
Professor
Abrams Lab
Research Interests: Molecular genetics of cell death; genomic “dark matter”; p53 tumor suppressor function; 3D genome organization

 
Massimo Attanasio, M.D.

Massimo Attanasio, M.D.
Assistant Professor
Attanasio Lab
Research Interests: Human genetics of kidney diseases, cystic kidney diseases and fibrosis, glomerular diseases

 
Xiaoying Bai, M.D., Ph.D.

Xiaoying Bai, M.D., Ph.D.
Assistant Professor
Research Interests: Transcriptional regulation of hematopoietic stem cell fate

 
Linda Baker, M.D.

Linda Baker, M.D. 
Professor
Baker Lab
Research Interests: Molecular mechanisms of normal genitourinary development and congenital birth defects

 
Laura Banaszynski, Ph.D.

Laura Banaszynski, Ph.D.
Assistant Professor
Banaszynski Lab
Research Interests: Chromatin Biology, developmental gene regulation, histone variants, stem cells

 
James Brugarolas, M.D., Ph.D.

James Brugarolas, M.D., Ph.D.
Associate Professor
Brugarolas Lab
Research Interests: Molecular mechanisms of cell growth proliferation control

 
Sandeep Burma, Ph.D.

Sandeep Burma, Ph.D.
Associate Professor
Burma Lab
Research Interests: DNA double-strand break sensing, signaling and repair: from mechanistic understanding to glioblastoma therapy

 
Ezra Burstein, M.D.

Ezra Burstein, M.D.
Associate Professor
Burstein Lab
Research Interests: Molecular control of inflammatory responses in the intestine, inflammation and cancer progression, regulation of NF-kB activity, COMM.D. proteins

 
Michael Buszczak, Ph.D.

Michael Buszczak, Ph.D.
Associate Professor
Buszczak Lab
Research Interests: Stem cell biology; niche signaling; chromatin; translational repression

 
Thomas Carroll, Ph.D.

Thomas Carroll, Ph.D.
Professor
Carroll Lab
Research Interests: Molecular mechanisms regulating kidney tubule formation and maintenance

 
Maria Chahrour, Ph.D.

Maria Chahrour, Ph.D.
Assistant Professor
Chahrour Lab
Research Interests: Genetics of autism spectrum disorder (ASD); molecular mechanisms underlying ASD; the ubiquitin proteasome pathway in neurodevelopmental disorders

 
Zhiljan James Chen, Ph.D.

Zhijian James Chen, Ph.D.
Professor
Chen Lab
Research Interests: NF-B signaling and the ubiquitin-proteasome pathway

 
Ondine Cleaver, Ph.D.

Ondine Cleaver, Ph.D.
Associate Professor
Cleaver Lab
Research Interests: Molecular mechanisms of cell fate specification during blood vessel development and organogenesis

 
Jonathan Cohen, Ph.D.

Jonathan Cohen, Ph.D.
Professor
Hobbs/Cohen Lab
Research Interests: Genetics of quantitative traits; genetic determinants of plasma lipoprotein levels

 
James Collins, Ph.D. 
 

James Collins, Ph.D.
Assistant Professor
Collins Lab 
Research Interests: Schistosomes are parasitic flatworms that cause significant disease and disability in more than 200 million of the world’s poorest people. Using a variety of functional genomic approaches we seek to understand fundamental aspects of schistosome biology, including the biology of somatic and reproductive stem cells.

 
Ralph DeBerardinis, M.D., Ph.D.

Ralph J. DeBerardinis, M.D., Ph.D.
Associate Professor
DeBerardinis Lab
Research Interests: Regulation of metabolism during cell growth and tumorigenesis; integrating signal transduction with metabolic flux; understanding pediatric metabolic diseases

 
Michael Dellinger, Ph.D.

Michael Dellinger, Ph.D.
Assistant Professor
Dellinger Lab
Research Interests: The development of the lymphatic vasculature and human diseases caused by errors in the development of the lymphatic vasculature

 
Peter Douglas, Ph.D.

Peter Douglas, Ph.D.
Assistant Professor
Douglas Lab
Research Interests: Molecular genetics of aging and stress response in blunt trauma, degenerative disease and cancer

 
Rene Galindo, M.D., Ph.D.

Rene L. Galindo, M.D., Ph.D.
Associate Professor
Galindo Lab
Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning

 
Christine Kim Garcia, M.D., Ph.D.

Christine Kim Garcia, M.D., Ph.D.
Professor
Garcia Lab
Research Interests: Pulmonary medicine; human genetics; molecular genetics

 
Jonathan M. Graff, M.D., Ph.D.

Jonathan M. Graff, M.D., Ph.D.
Professor
Graff Lab
Research Interests: Signaling pathways in development and cancer

 
Rana Gupta, Ph.D.

Rana Gupta, Ph.D.
Assistant Professor
Gupta Lab
Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease.

 
Mark Henkemeyer, Ph.D.

Mark Henkemeyer, Ph.D.
Professor
Henkemeyer Lab 
Research Interests: Molecular genetics of axon guidance and brain development; bidirectional tyrosine kinase signaling

 
Helen Hobbs, M.D.

Helen H. Hobbs, M.D.
Professor
Hobbs/Cohen Lab
Research Interests: Identification of genetic factors contributing to inter-individual differences in the concentration of lipoproteins in the blood

 
Gary Hon, Ph.D.

Gary Hon, Ph.D.
Assistant Professor
Hon Lab
Research Interests: Developing (epi)genomic/bioinformatic tools to assess and predict the functions of regulatory elements, epigenetic biomarkers of disease state, epigenetics in development and disease, global regulation of mammalian gene expression, non-coding genome function

 
Jenny Hsieh, Ph.D.

Jenny Hsieh, Ph.D.
Associate Professor
Hsieh Lab
Research Interests: Stem cell biology; neurogenesis and gliogenesis in CNS; chromatin remodeling; neurological diseases

 

Lily Huang, Ph.D.
Associate Professor
Huang Lab
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer

 
Jenna Jewell, Ph.D.

Jenna Jewell, Ph.D.
Assistant Professor
Jewell Lab
Research Interests: Cancer Biology, CRISPR Genome Editing, Mechanistic Target of Rapamycin (mTOR), Nutrient Sensing, Signal Transduction

 
Huaqi Jiang, Ph.D.

Huaqi Jiang, Ph.D.
Assistant Professor
H. Jiang Lab
Research Interests: Regulation of tissue homeostasis and regeneration mediated by stem cells

 
Jin Jiang, Ph.D.

Jin Jiang, Ph.D.
Professor
J. Jiang Lab
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes

 
Jane Johnson, Ph.D.

Jane E. Johnson, Ph.D.
Professor
Johnson Lab
Research Interests: Development of the mammalian nervous system; transcriptional regulation of neural cell-type specification

 
Taekyung Kim, Ph.D.

Taekyung Kim, Ph.D.
Assistant Professor
Kim Lab
Research Interests: Genetic and epigenetic programs underlying brain development and function

 
Helmut Kramer, Ph.D.

Helmut Kramer, Ph.D.
Professor
Kramer Lab
Research Interests: Molecular genetics endosomal trafficking in Drosophila

 
Lee Krause, Ph.D.

W. Lee Kraus, Ph.D.
Professor
Kraus Lab
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus; biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation

 
Bing Li, Ph.D.

Bing Li, Ph.D.
Assistant Professor
Li Lab
Research Interests: Chromatin regulation and eukaryotic transcription

 
Rueyling Lin, Ph.D.

Rueyling Lin, Ph.D.
Professor
Lin Lab
Research Interests: Cell-fate specification in Caenorhabditis elegans early development

 
Yi Liu, Ph.D.

Yi Liu, Ph.D.
Professor
Liu Lab
Research Interests: Molecular mechanisms of circadian biological clocks

 
Zhi-Ping Liu, Ph.D.

Zhi-Ping Liu, Ph.D.
Associate Professor
Liu Lab
Research Interests: Elucidate transcriptional regulatory mechanisms of genes involved in cardiovascular diseases and characterize the signaling pathways coupling these transcriptional programs to extracellular signals that trigger this disease

 
Lawrence Lum, Ph.D.

Lawrence Lum, Ph.D.
Associate Professor
Lum Lab
Research Interests: How information from multiple signaling molecules, including Hh and Wg, integrate in developmental and disease-related contexts

 
Denise Marciano, M.D., Ph.D.

Denise Marciano, M.D., Ph.D.
Assistant Professor
Marciano Lab
Research Interests: Regulation of cell-cell adhesion during tubule and glomerular formation and in polycystic kidney disease

 

David McFadden, M.D., Ph.D.
Assistant Professor
McFadden Lab
Research Interests: Genetically-engineered mouse models of cancer, chemical and genetic screens for new vulnerabilities in small cell lung cancer and Ewing sarcoma

 
Joshua Mendell, M.D., Ph.D.

Joshua Mendell, M.D., Ph.D.
Professor
Mendell Lab
Research Interests: Regulation and function of mammalian miRNAs and other noncoding RNAs in normal physiology and disease

 
Sean Morrison, Ph.D.

Sean Morrison, Ph.D.
Professor
Morrison Lab
Research Interests: Cancer stem cell biology; Melanoma cell proliferation and metastasis; Stem cell aging; Stem cell self-renewal

 
Saikat Mukhopadhyay, M.D., Ph.D.

Saikat Mukhopadhyay, M.D., Ph.D.
Assistant Professor
Mukhopadhyay Lab
Research Interests: Role of the primary cilia in normal development and cancer; functional proteomics in ciliary diseases; ciliary signaling pathways

 
Nikhil Munshi, M.D., Ph.D.

Nikhil Munshi, M.D., Ph.D.
Assistant Professor
Munshi Lab
Research Interests: Transcriptional mechanisms that orchestrate formation and function of the cardiac conduction system

 
Kathryn O'Donnell, Ph.D.

Kathryn O'Donnell, Ph.D.
Assistant Professor
O'Donnell Lab
Research Interests: Identification and characterization of cancer-associated genes using transposon-mediated mutagenesis

 
Eric Olson, Ph.D.

Eric N. Olson, Ph.D.
Professor
Olson Lab
Research Interests: Transcriptional control of cell differentiation; muscle development

 

Duojia Pan, Ph.D.
Professor
Pan Lab
Research Interests: Size-control mechanisms in development, regeneration, and cancer

 
Hesham Sadek, M.D., Ph.D.

Hesham Sadek, M.D., Ph.D.
Associate Professor
Sadek Lab
Research Interests: Metabolic profiling of stem cells

 
Jay Schneider, M.D., Ph.D.

Jay Schneider, M.D., Ph.D.
Associate Professor
Schneider Lab
Research Interests: Stem Cells, Cancer, microRNAs, small molecules

 
Jerry Shay, Ph.D.

Jerry W. Shay, Ph.D.
Professor
Shay Lab
Research Interests: Defining the molecular mechanisms of human cell immortalization; telomeres and telomerase in aging and cancer

 
Stephen Skapek, M.D.

Stephen Skapek, M.D.
Professor
Skapek Lab
Research Interests: Tumor suppressor gene function; Angiogenesis; Skeletal muscle differentiation; Oncogene-induced senescence

 
Vincent Tagliabracci, Ph.D.

Vincent Tagliabracci, Ph.D.
Assistant Professor
Tagliabracci Lab
Research Interests: Kinases in the secretory pathway and the extracellular space; secreted protein and peptide hormone phosphorylation; CRISPR/Cas9 genome editing

 
Zhigao Wang, Ph.D.

Zhigao Wang, Ph.D.
Assistant Professor
Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death

 
Tom Wilkie, Ph.D.

Tom Wilkie, Ph.D.
Associate Professor
Wilkie Lab
Research Interests: G-protein signaling during mouse development, energy homeostasis, and feeding behavior

 
Carol Wise, Ph.D.

Carol Wise, Ph.D.
Professor
Wise Lab
Research Interests: Genetics of pediatric musculoskeletal and autoinflammatory diseases

 
Woodring Wright, M.D., Ph.D.

Woodring E. Wright, M.D., Ph.D.
Professor
Wright Lab
Research Interests: The role of telomeres and telomerase in cellular senescence and cancer; developing normal immortalized cells for therapeutic uses

 
Jiang Wu, Ph.D.

Jiang Wu, Ph.D.
Assistant Professor
Wu Lab
Research Interests: Chromatin regulation of neural development; neural stem cell differentiation; activity dependent gene expression

 
Chao Xing, Ph.D.

Chao Xing, Ph.D.
Associate Professor
Xing Lab
Research Interests: Statistical genetics, genetic epidemiology, bioinformatics, gene mapping for complex traits

 
Jian Xu, Ph.D.

Jian Xu, Ph.D.
Assistant Professor
Xu Lab
Research Interests: Epigenetic and genetic basis of disease-associated genes and gene networks in blood stem cell development and disorders, focusing on both single gene and genomic levels

 
Chun-Li Zhang, Ph.D.

Chun-Li Zhang, Ph.D.
Associate Professor
Zhang Lab
Research Interests: Nuclear receptor signaling and adult neural stem cells

 
Hao Zhu, M.D.

Hao Zhu, M.D.
Assistant Professor
Zhu Lab
Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer

 

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

 
Rhonda Basel-Duby, Ph.D.

Rhonda Bassel-Duby, Ph.D.
Professor
Research Interests: Genetic mechanisms of muscle development, growth, disease and regeneration

 
Elizabeth Chen, Ph.D.

Elizabeth Chen, Ph.D.
Professor
Research Interests: Cell-cell fusion, actin cytosleletal dynamics, mechanobiology, muscle development and regeneration.

 
Robert Hammer, Ph.D.

Robert E. Hammer, Ph.D.
Professor
Research Interests: Transforming growth factor beta signaling

 
Raymond MacDonald, Ph.D.

Raymond J. MacDonald, Ph.D.
Professor
Research Interests: Transcriptional control of organogenesis

 
Stuart Ravnik, Ph.D.

Stuart Ravnik, Ph.D.
Associate Dean, Graduate School of Biomedical Sciences
Research Interests: Molecular control of germ-cell development and meiosis

 
Scott Robertson, Ph.D.

Scott Robertson, Ph.D.
Assistant Professor
Research Interests: Lineage commitment from mesoderm; initiation of hematopoietic development

 
Andrew Zinn, M.D., Ph.D.

Andrew R. Zinn, M.D., Ph.D.
Professor
Zinn Lab
Research Interests: Genetic disorders of human growth and reproduction; Turner syndrome; infertility; obesity