Genetics, Development and Disease Faculty
John M. Abrams, Ph.D.
Research Interests: Molecular genetics of cell death; genomic “dark matter”; p53 tumor suppressor function; 3D genome organization
Massimo Attanasio, M.D.
Xiaoying Bai, M.D., Ph.D.
Research Interests: Transcriptional regulation of hematopoietic stem cell fate
Linda Baker, M.D.
Research Interests: Molecular mechanisms of normal genitourinary development and congenital birth defects
James Brugarolas, M.D., Ph.D.
Research Interests: Molecular mechanisms of cell growth proliferation control
Sandeep Burma, Ph.D.
Research Interests: DNA double-strand break sensing, signaling and repair: from mechanistic understanding to glioblastoma therapy
Ezra Burstein, M.D.
Research Interests: Molecular control of inflammatory responses in the intestine, inflammation and cancer progression, regulation of NF-kB activity, COMM.D. proteins
Michael Buszczak, Ph.D.
Research Interests: Stem cell biology; niche signaling; chromatin; translational repression
Thomas Carroll, Ph.D.
Research Interests: Molecular mechanisms regulating kidney tubule formation and maintenance
Zhijian James Chen, Ph.D.
Research Interests: NF-B signaling and the ubiquitin-proteasome pathway
Ondine Cleaver, Ph.D.
Research Interests: Molecular mechanisms of cell fate specification during blood vessel development and organogenesis
Jonathan Cohen, Ph.D.
Research Interests: Genetics of quantitative traits; genetic determinants of plasma lipoprotein levels
James Collins, Ph.D.
Research Interests: Schistosomes are parasitic flatworms that cause significant disease and disability in more than 200 million of the world’s poorest people. Using a variety of functional genomic approaches we seek to understand fundamental aspects of schistosome biology, including the biology of somatic and reproductive stem cells.
Ralph J. DeBerardinis, M.D., Ph.D.
Research Interests: Regulation of metabolism during cell growth and tumorigenesis; integrating signal transduction with metabolic flux; understanding pediatric metabolic diseases
Michael Dellinger, Ph.D.
Research Interests: The development of the lymphatic vasculature and human diseases caused by errors in the development of the lymphatic vasculature.
Rene L. Galindo, M.D., Ph.D.
Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning
Christine Kim Garcia, M.D., Ph.D.
Research Interests: Pulmonary medicine; human genetics; molecular genetics
Joseph Garcia, M.D., Ph.D.
Research Interests: Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia
William T. Garrard, Ph.D.
Research Interests: Regulation of immunoglobulin gene expression during B-cell development; chromatin structure-function relationships; regulation of the terminal stages of apoptosis
Robert Gerard, Ph.D.
Research Interests: Specific research projects in my lab focus on in vivo tumor targeting using recombinant protein and adenoviral vector technology. Peptide ligands and monoclonal antibodies, as well as new technologies, are used as proven methods of targeting tumors for molecular imaging and therapy.
Jonathan M. Graff, M.D., Ph.D.
Research Interests: Signaling pathways in development and cancer
Rana Gupta, Ph.D.
Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease.
Robert E. Hammer, Ph.D.
Research Interests: Transforming growth factor beta signaling
F. Kent Hamra, Ph.D.
Research Interests: Sperm stem cell development; application of sperm stem cells in functional genomics; targeting sperm cell biology for fertility management and regenerative medicine
Mark Henkemeyer, Ph.D.
Research Interests: Molecular genetics of axon guidance and brain development; bidirectional tyrosine kinase signaling
Helen H. Hobbs, M.D.
Research Interests: Identification of genetic factors contributing to inter-individual differences in the concentration of lipoproteins in the blood
Jenny Hsieh, Ph.D.
Research Interests: Stem cell biology; neurogenesis and gliogenesis in CNS; chromatin remodeling; neurological diseases
Lily Huang, Ph.D.
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer
Peter Igarashi, M.D.
Research Interests: Transcriptional control of tissue-specific gene expression and organogenesis; polycystic kidney disease
Huaqi Jiang, Ph.D.
H. Jiang Lab
Research Interests: Regulation of tissue homeostasis and regeneration mediated by stem cells
Jin Jiang, Ph.D.
J. Jiang Lab
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes
Jane E. Johnson, Ph.D.
Research Interests: Development of the mammalian nervous system; transcriptional regulation of neural cell-type specification
Tae-Kyung Kim, Ph.D.
Research Interests: Genetic and epigenetic programs underlying brain development and function
Helmut Kramer, Ph.D.
Research Interests: Molecular genetics endosomal trafficking in Drosophila
W. Lee Kraus, Ph.D.
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus; biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation
Bing Li, Ph.D.
Research Interests: Chromatin regulation and eukaryotic transcription
Rueyling Lin, Ph.D.
Research Interests: Cell-fate specification in Caenorhabditis elegans early development
Yi Liu, Ph.D.
Research Interests: Molecular mechanisms of circadian biological clocks
Zhi-Ping Liu, Ph.D.
Zhi-Ping Liu Lab
Research Interests: Elucidate transcriptional regulatory mechanisms of genes involved in cardiovascular diseases and characterize the signaling pathways coupling these transcriptional programs to extracellular signals that trigger this disease
Lawrence Lum, Ph.D.
Research Interests: How information from multiple signaling molecules, including Hh and Wg, integrate in developmental and disease-related contexts
Raymond J. MacDonald, Ph.D.
Research Interests: Transcriptional control of organogenesis
Joshua Mendell, M.D., Ph.D.
Research Interests: Regulation and function of mammalian miRNAs and other noncoding RNAs in normal physiology and disease
Sean Morrison, Ph.D.
Research Interests: Cancer stem cell biology; Melanoma cell proliferation and metastasis; Stem cell aging; Stem cell self-renewal
Saikat Mukhopadhyay, M.D., Ph.D.
Research Interests: Role of the primary cilia in normal development and cancer, Functional proteomics in ciliary diseases, Ciliary signaling pathways
Nikhil Munshi, M.D., Ph.D.
Research Interests: Transcriptional mechanisms that orchestrate formation and function of the cardiac conduction system.
Kathryn A. O'Donnell, Ph.D.
Research Interests: Identification and characterization of cancer-associated genes using transposon-mediated mutagenesis
Eric N. Olson, Ph.D.
Research Interests: Transcriptional control of cell differentiation; muscle development
Luis Parada, Ph.D.
Research Interests: The role of proto-oncogenes in vertebrate development; TRK receptors and neurotropins
Hesham Sadek, M.D., Ph.D.
Research Interests: Metabolic profiling of stem cells
Jay Schneider, M.D., Ph.D.
Research Interests: Stem Cells, Cancer, microRNAs, small molecules
Jerry W. Shay, Ph.D.
Research Interests: Defining the molecular mechanisms of human cell immortalization; telomeres and telomerase in aging and cancer
Stephen Skapek, M.D.
Research Interests: Tumor suppressor gene function; Angiogenesis; Skeletal muscle differentiation; Oncogene-induced senescence
William J. Snell, Ph.D.
Research Interests: Understanding the mechanisms of cell-cell adhesion induced signaling and cell-cell fusion during fertilization
Zhigao Wang, Ph.D.
Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death.
Tom Wilkie, Ph.D.
Research Interests: G-protein signaling during mouse development, energy homeostasis, and feeding behavior
Carol Wise, Ph.D.
Research Interests: Genetics of pediatric musculoskeletal and autoinflammatory diseases
Woodring E. Wright, M.D., Ph.D.
Research Interests: The role of telomeres and telomerase in cellular senescence and cancer; developing normal immortalized cells for therapeutic uses
Jiang Wu, Ph.D.
Research Interests: Chromatin regulation of neural development; neural stem cell differentiation; activity dependent gene expression
Chao Xing, Ph.D.
Research Interests: Statistical genetics, genetic epidemiology, bioinformatics, gene mapping for complex traits.
Jian Xu, Ph.D.
Research Interests: We are investigating the epigenetic and genetic basis of disease-associated genes and gene networks in blood stem cell development and disorders, focusing on both single gene and genomic levels.
Hiromi Yanagisawa, M.D., Ph.D.
Research Interests: Extracellular matrix proteins and maintenance of vessel microenvironment during development and disease; molecular mechanism of neural crest development in vivo
Chun-Li Zhang, Ph.D.
Research Interests: Nuclear receptor signaling and adult neural stem cells
Hao Zhu, M.D.
Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer
Andrew R. Zinn, M.D., Ph.D.
Research Interests: Genetic disorders of human growth and reproduction; Turner syndrome; infertility; obesity
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.
Stuart Ravnik, Ph.D.
Research Interests: Molecular control of germ-cell development and meiosis
Scott Robertson, Ph.D.
Research Interests: Lineage commitment from mesoderm; initiation of hematopoietic development