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Signaling pathways in cilia

The recruitment of certain GPCRs preferentially to the ciliary membrane could be mediated by several factors. Read More

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Cilia & Development

As Gpr161 knockout embryos are embryonic lethal by E10.5, its important to develop conditional knockout strategies for dissecting the role of this receptor during later embryonic and adult development. Read More

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Proteomics in ciliary diseases

Our ongoing studies with the IFT-A complex and its interacting partners suggest that this conserved complex interacts with a set of novel effectors in mammalian cells including Tulp3. Read More

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Functional proteomics

An important aspect of discovering the functionalities of proteins is in trying to understand how they interact with each other, in order to determine their 'social behavior.' Read More

From Saikat's Desk ...

In science, nothing is more thrilling than finding an answer to a long-standing mystery.

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Background

We have discovered a fundamentally new trafficking and signaling pathway for a GPCR in the basal repression machinery of Shh signaling.

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Research

Our research aims at developing a multi-level functional proteomic approach to study ciliary signaling in cellular and organismal contexts.

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