Cancer Biology Faculty
Jerry Shay, Ph.D.
Research Interests: Molecular mechanisms of human cellular aging and immortalization; the role of telomeres and telomerase in cancer
John M. Abrams, Ph.D.
Research Interests: Molecular genetics of cell death in cancer
James Amatruda, M.D., Ph.D.
Research Interests: Defining novel cancer genes and understanding the developmental biology of tumors using the zebrafish system
Asaithamby Aroumougame, Ph.D.
Research Interests: Cellular and molecular understanding of Werner Syndrome, Fanconi anemia, and space radiation induced carcinogenesis
Robert Bachoo, M.D., Ph.D.
Research Interests: Molecular mechanisms underlying brain tumors
David Boothman, Ph.D.
Research Interests: Low dose radiation and cancer
Rolf A. Brekken, Ph.D.
Research Interests: Tumor-host interactions in pancreatic cancer
James Brugarolas, M.D., Ph.D.
Research Interests: Molecular mechanisms of cell growth and proliferation control
Richard Bruick, Ph.D.
Research Interests: Regulation of the mammalian hypoxic response pathway in cancer
Sandeep Burma, Ph.D.
Research Interests: DNA double-strand break sensing, signaling, and repair: from mechanistic understanding to glioblastoma therapy
Diego Castrillon, M.D., Ph.D.
Research Interests: PI3K/PTEN/AKT/FoxO pathways in cancer biology
Benjamin Chen, Ph.D.
Research Interests: Radiation Biology; DNA damage response in somatic stem cells to tissue homeostasis and cancer initiation
Melanie H. Cobb, Ph.D.
Research Interests: Function and regulation of protein kinases in signal transduction pathways in breast cancer
Ian Corbin, Ph.D.
Research Interests: Utilizing molecular imaging and nanomedicine techniques to better characterize, detect, and treat hepatocellular carcinoma
David R. Corey, Ph.D.
Research Interests: Cancer therapeutics: Engineering proteins and nucleic acids for novel function
Gaudenz Danuser, Ph.D.
Research Interests: Regulation of cell morphogenesis during metastasis; roles of mechanics in cell survival and drug resistance
Jef De Brabander, Ph.D.
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode-of-action, using molecular pharmacology and biochemistry for the development of novel cancer therapeutics
Ralph DeBerardinis, M.D., Ph.D.
Research Interests: Metabolic pathways that support tumor cell growth and exploiting tumor metabolism to improve imaging and therapy in cancer
Beatriz Fontoura, Ph.D.
Research Interests: Nuclear transport pathways as regulators of cell cycle, cancer, and antiviral response
Rene Galindo, M.D., Ph.D.
Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning
Jinming Gao, Ph.D.
Research Interests: Nanoparticles for cancer therapeutic drug delivery
Robert Gerard, Ph.D.
Research Interests: Targeting of recombinant adenovirus vectors to tumors
Amyn Habib, M.D.
Research Interests: Interactions between inflammatory and oncogenic signaling pathways with a focus on glioblastoma (GBM) as our cancer model
Robert E. Hammer, Ph.D.
Research Interests: Transforming growth factor beta signaling
Jer-Tsong (J.T.) Hsieh, Ph.D.
Research Interests: Human cancer gene therapy; signaling defects in urogenital cancers
Lily Huang, Ph.D.
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer
Jenna Jewell, Ph.D.
Research Interests: Cancer Biology, CRISPR Genome Editing, Mechanistic Target of Rapamycin (mTOR), Nutrient Sensing, Signal Transduction
Jin Jiang, Ph.D.
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes
Qiu-Xing Jiang, Ph.D.
Research Interests: Structure and function of large membrane assemblies, including ion channels and transporters using electron cryo-microscopy and crystallographic analysis to generate 3D structures and perform functional studies in in vitro or in vivo systems
Ralf Kittler, Ph.D.
Research Interests: Functions of cancer-relevant transcription factors and to translate this knowledge into new approaches for the detection and treatment of cancer
Erik Knudsen, Ph.D.
Research Interests: Tumor suppressor pathways in breast cancer etiology, disease progression, and therapeutic response
Beth Levine, M.D.
Research Interests: Role of autophagy in tumor suppression
Lawrence Lum, Ph.D.
Research Interests: How information from multiple signaling molecules, including Hh and Wg, integrates in development and cancer
Weibo Luo, Ph.D.
Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis
Ram Mani, Ph.D.
Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; Genomic rearrangements in cancer; Transcriptional regulation in prostate cancer
Elisabeth Martinez, Ph.D.
Research Interests: Discovery and characterization of novel chemical epigenetic modulators of gene expression with specific anti-cancer activity
Ralph Mason, Ph.D.
Research Interests: Animal imaging in cancer
Joshua Mendell, M.D., Ph.D.
Research Interests: Regulation and function of microRNAs and other noncoding RNAs in normal physiology and cancer.
John Minna, M.D.
Research Interests: Molecular pathogenesis of human cancer; signal transduction in human tumors; cancer stem cells; targeted cancer therapy
Sean Morrison, Ph.D.
Research Interests: Normal and cancerous stem cells
Saikat Mukhopadhyay, M.D., Ph.D.
Research Interests: Role of primary cilia in normal development and cancer, functional proteomics in ciliary diseases, ciliary signaling pathways
Jerry Y. Niederkorn, Ph.D.
Research Interests: Immune surveillance of intraocular tumors; immune modulation of cancer metastases
Kathryn A. O'Donnell, Ph.D.
Research Interests: Identification and characterization of cancer-associated genes using transposon-mediated mutagenesis
Luis F. Parada, Ph.D.
Research Interests: Mechanisms of neural development; trk receptors and neurotrophins; mouse models of neurological tumors
Gray Pearson, Ph.D.
Research Interests: The molecular regulation of breast cancer progression using in vitro and in vivo models
Ryan Potts, Ph.D.
Research Interests: Role of ubiquitin ligases in tumor initiation and progression, vesicular trafficking, and genome stability.
Theodora Ross, M.D., Ph.D.
Research Interests: The Ross Laboratory investigates how dysfunctional endocytosis, tyrosine kinase oncogenes, and the BRCA1/2 tumor suppressor genes lead to transformation of normal cells into cancer cells.
Michael Roth, Ph.D.
Research Interests: High throughput screening for novel cancer therapeutics; recognition and sorting of cell-surface glycoproteins
Pier Paolo Scaglioni, M.D.
Research Interests: Characterization of the function of the PML tumor suppressor; mechanisms of K-RAS induced Tumorigenesis; role of oncogene induced replicative senescence in tumor suppression; mouse models of lung cancer
Joachim Seemann, Ph.D.
Research Interests: To understand the mechanisms that regulate the mitotic division of the Golgi in mammalian cells as it relates to cancer
Daniel Siegwart, Ph.D.
Research Interests: Polymer and materials chemistry, drug and gene delivery, RNAi, biomedical imaging, detection and treatment of cancer
Stephen Skapek, M.D.
Research Interests: Tumor suppressor gene function; Angiogenesis; Skeletal muscle differentiation; Oncogene-induced senescence
Michael Story, Ph.D.
Research Interests: Radiation biology/oncology; cancer genomics; intrinsic radiosensitivity
Yihong Wan, Ph.D.
Research Interests: Regulation of the initiation, progression, and bone metastasis of breast cancer by the micro-environment
Richard Wang, M.D., Ph.D.
Research Interests: Regulation of glucose uptake; autophagy and skin cancer
Zhigao Wang, Ph.D.
Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death
Kenneth Westover, M.D., Ph.D.
Research Interests: The Westover Lab works at the intersections of biochemistry, structural biology, chemical biology, and chemistry as part of a collaborative team to understand and manipulate the molecular basis of cancer
Michael White, Ph.D.
Research Interests: Molecular mechanisms for control of cell growth and differentiation
Angelique Whitehurst, Ph.D.
Research Interests: The role of ectopically activated gametogenic programs in supporting tumor cell proliferation and survival
Thomas Wilkie, Ph.D.
Research Interests: G-protein signaling during mouse development, energy homeostasis, and feeding behavior
Woodring E. Wright, M.D., Ph.D.
Research Interests: The role of telomeres and telomerase in cellular senescence and cancer
Yang Xie, Ph.D.
Research Interests: Bioinformatics; Integrative Analysis; Predictive Models; Biomarkers in Cancer
Jian Xu, Ph.D.
Research Interests: We are investigating the epigenetic and genetic basis of disease-associated genes and gene networks in blood stem cell development and disorders, focusing on both single gene and genomic levels.
Hasan Zaki, Ph.D.
Research Interests: How intestinal microbiota and pathogen recognition receptors regulate gastrointestinal cancer
Qing Zhong, M.D., Ph.D.
Research Interests: Biochemical mechanisms of mammalian autophagy, apoptosis, and necrosis and their implications in cancer
Hao Zhu, M.D.
Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer.
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.