Cancer Biology Faculty

Jerry Shay, Ph.D.
Program Chair
Shay/Wright Lab
Research Interests: Molecular mechanisms of human cellular aging and immortalization; the role of telomeres and telomerase in cancer


John M. Abrams, Ph.D.
Professor
Abrams Lab
Research Interests: Molecular genetics of cell death in cancer


Steve Altschuler, Ph.D.
Associate Professor
Altschuler/Wu Lab
Research Interests: Understanding the dynamic responses of cancer cells to drugs, and their molecular bases for drug-resistance


James Amatruda, M.D., Ph.D.
Associate Professor
Research Interests: Defining novel cancer genes and understanding the developmental biology of tumors using the zebrafish system


Asaithamby Aroumougame, Ph.D.
Assistant Professor
Research Interests: Cellular and molecular understanding  of Werner Syndrome, Fanconi anemia, and space radiation induced carcinogenesis


Robert Bachoo, M.D., Ph.D.
Assistant Professor
Research Interests: Molecular mechanisms underlying brain tumors


David Boothman, Ph.D.
Professor
Boothman Lab
Research Interests: Low dose radiation and cancer


Rolf A. Brekken, Ph.D.
Associate Professor
Brekken Lab
Research Interests: Tumor-host interactions in pancreatic cancer


Kathlynn Brown, Ph.D.
Assistant Professor
Brown Lab
Research Interests: Development of tumor targeting reagents for drug delivery and molecular imaging


James Brugarolas, M.D., Ph.D.
Associate Professor
Brugarolas Lab
Research Interests: Molecular mechanisms of cell growth and proliferation control


Richard Bruick, Ph.D.
Associate Professoer
Bruick Lab
Research Interests: Regulation of the mammalian hypoxic response pathway in cancer


Sandeep Burma, Ph.D.
Associate Professor
Burma Lab
Research Interests: DNA double-strand break sensing, signaling, and repair: from mechanistic understanding to glioblastoma therapy


Diego Castrillon, M.D., Ph.D.
Associate Professor
Castrillion Lab
Research Interests: PI3K/PTEN/AKT/FoxO pathways in cancer biology


Benjamin Chen, Ph.D.
Associate Professor
Chen Lab
Research Interests: Radiation Biology; DNA damage response in somatic stem cells to tissue homeostasis and cancer initiation


David Chen, Ph.D.
Professor
Chen Lab
Research Interests: Radiation biology and DNA damage signaling


Melanie H. Cobb, Ph.D.
Professor
Research Interests: Function and regulation of protein kinases in signal transduction pathways in breast cancer


Ian Corbin, Ph.D.
Assistant Professor
Research Interests: Utilizing molecular imaging and nanomedicine techniques to better characterize, detect, and treat hepatocellular carcinoma


David R. Corey, Ph.D.
Professor
Corey Lab
Research Interests: Cancer therapeutics: Engineering proteins and nucleic acids for novel function


Jef De Brabander, Ph.D.
Professor
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode-of-action, using molecular pharmacology and biochemistry for the development of novel cancer therapeutics


Ralph DeBerardinis, M.D., Ph.D.
Associate Professor
DeBerardinis Lab
Research Interests: Metabolic pathways that support tumor cell growth and exploiting tumor metabolism to improve imaging and therapy in cancer


Beatriz Fontoura, Ph.D.
Professor
Fontoura Lab
Research Interests: Nuclear transport pathways as regulators of cell cycle, cancer, and antiviral response


Rene Galindo, M.D., Ph.D.
Assistant Professor
Galindo Lab
Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning


Jinming Gao, Ph.D.
Professor
Gao Lab
Research Interests: Nanoparticles for cancer therapeutic drug delivery


Robert Gerard, Ph.D.
Associate Professor
Gerard Lab
Research Interests: Targeting of recombinant adenovirus vectors to tumors


Amyn Habib, M.D.
Associate Professor
Habib Lab
Research Interests: Interactions between inflammatory and oncogenic signaling pathways with a focus on glioblastoma (GBM) as our cancer model


Robert E. Hammer, Ph.D.
Professor
Research Interests: Transforming growth factor beta signaling


Jer-Tsong (J.T.) Hsieh, Ph.D.
Professor
Research Interests: Human cancer gene therapy; signaling defects in urogenital cancers


Lily Huang, Ph.D.
Assistant Professor
Huang Lab
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer


Jin Jiang, Ph.D.
Professor
Jiang Lab
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes


Qiu-Xing Jiang, Ph.D.
Assistant Professor
Jiang Lab
Research Interests: Structure and function of large membrane assemblies, including ion channels and transporters using electron cryo-microscopy and crystallographic analysis to generate 3D structures and perform functional studies in in vitro or in vivo systems


Ralf Kittler, Ph.D.
Assistant Professor
Kittler Lab
Research Interests: Functions of cancer-relevant transcription factors and to translate this knowledge into new approaches for the detection and treatment of cancer


Erik Knudsen, Ph.D.
Professor
Research Interests: Tumor suppressor pathways in breast cancer etiology, disease progression, and therapeutic response


Beth Levine, M.D.
Professor
Levine Lab
Research Interests: Role of autophagy in tumor suppression


Lawrence Lum, Ph.D.
Associate Professor
Lum Lab
Research Interests: How information from multiple signaling molecules, including Hh and Wg, integrates in development and cancer


Elisabeth Martinez, Ph.D.
Assistant Professor
Martinez Lab
Research Interests: Discovery and characterization of novel chemical epigenetic modulators of gene expression with specific anti-cancer activity


Ralph Mason, Ph.D.
Professor
Mason Lab
Research Interests: Animal imaging in cancer


Joshua Mendell, M.D., Ph.D.
Professor
Mendell Lab
Research Interests: Regulation and function of microRNAs and other noncoding RNAs in normal physiology and cancer.


John Minna, M.D.
Professor
Research Interests: Molecular pathogenesis of human cancer; signal transduction in human tumors; cancer stem cells; targeted cancer therapy


Hamid Mirzaei, Ph.D.
Assistant Professor
Mirzaei Lab
Research Interests: Investigation of ubiquitin-dependent mechanisms and their role in tumor progression.


Sean Morrison, Ph.D.
Professor
Morrison Lab
Research Interests: Normal and cancerous stem cells


Saikat Mukhopadhyay, M.D., Ph.D.
Assistant Professor
Mukhopadhyay Lab
Research Interests: Role of primary cilia in normal development and cancer, functional proteomics in ciliary diseases, ciliary signaling pathways


Jerry Y. Niederkorn, Ph.D.
Professor
Niederkorn Lab
Research Interests: Immune surveillance of intraocular tumors; immune modulation of cancer metastases


Kathryn A. O'Donnell, Ph.D.
Assistant Professor
O'Donnell Lab
Research Interests: Identification and characterization of cancer-associated genes using transposon-mediated mutagenesis


Tej Pandita, Ph.D.
Professor
Pandita Lab
Research Interests: Revealing how chromatin modification plays a role in DNA Damage Response, the information that will provide health professionals a molecular diagnostic approach to predict the suitability and response of an individual for radiotherapy


Luis F. Parada, Ph.D.
Professor
Parada Lab
Research Interests: Mechanisms of neural development; trk receptors and neurotrophins; mouse models of neurological tumors


Gray Pearson, Ph.D.
Assistant Professor
Research Interests: The molecular regulation of breast cancer progression using in vitro and in vivo models


Ryan Potts, Ph.D.
Assistant Professor
Potts Lab
Research Interests: Role of ubiquitin ligases in tumor initiation and progression, vesicular trafficking, and genome stability.


Theodora Ross, M.D., Ph.D.
Professor
Ross Lab
Research Interests: The Ross Lab oratory investigates how dysfunctional endocytosis, tyrosine kinase oncogenes, and the BRCA1/2 tumor suppressor genes lead to transformation of normal cells into cancer cells.


Michael Roth, Ph.D.
Professor
Roth Lab
Research Interests: High throughput screening for novel cancer therapeutics; recognition and sorting of cell-surface glycoproteins


Pier Paolo Scaglioni, M.D.
Assistant Professor
Scaglioni Lab
Research Interests: Characterization of the function of the PML tumor suppressor; mechanisms of K-RAS induced Tumorigenesis; role of oncogene induced replicative senescence in tumor suppression; mouse models of lung cancer


Joachim Seemann, Ph.D.
Associate Professor
Seemann Lab
Research Interests: To understand the mechanisms that regulate the mitotic division of the Golgi in mammalian cells as it relates to cancer


Stephen Skapek, M.D.
Professor
Skapek Lab
Research Interests: Tumor suppressor gene function; Angiogenesis; Skeletal muscle differentiation; Oncogene-induced senescence


Michael Story, Ph.D.
Associate Professor
Story Lab
Research Interests: Radiation biology/oncology; cancer genomics; intrinsic radiosensitivity


Yihong Wan, Ph.D.
Assistant Professor
Wan Lab
Research Interests: Regulation of the initiation, progression, and bone metastasis of breast cancer by the micro-environment


Richard Wang, M.D., Ph.D.
Assistant Professor
Research Interests: Regulation of glucose uptake; autophagy and skin cancer


Zhigao Wang, Ph.D.
Assistant Professor
Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death


Kenneth Westover, M.D., Ph.D.
Assistant Professor
Westover Lab
Research Interests: The Westover Lab works at the intersections of biochemistry, structural biology, chemical biology, and chemistry as part of a collaborative team to understand and manipulate the molecular basis of cancer


Michael White, Ph.D.
Professor
White Lab
Research Interests: Molecular mechanisms for control of cell growth and differentiation


Angelique Whitehurst, Ph.D.
Assistant Professor
Whitehurst Lab
Research Interests:  The role of ectopically activated gametogenic programs in supporting tumor cell proliferation and survival


Woodring E. Wright, M.D., Ph.D.
Professor
Shay/Wright Lab
Research Interests: The role of telomeres and telomerase in cellular senescence and cancer


Lani Wu, Ph.D.
Associate Professor
Altschuler/Wu Lab
Research Interests: Understanding the dynamic responses of cancer cells to drugs and their molecular bases for drug resistance


Yang Xie, Ph.D.
Associate Professor
Research Interests: Bioinformatics; Integrative Analysis; Predictive Models; Biomarkers in Cancer


Qing Zhong, M.D., Ph.D.
Associate Professor
Zhong Lab
Research Interests: Biochemical mechanisms of mammalian autophagy, apoptosis, and necrosis and their implications in cancer


Hao Zhu, M.D.
Assistant Professor
Zhu Lab
Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer.