Biomedical & Molecular Imaging Track
Dean Sherry, Ph.D.
The Biomedical & Molecular Imaging Track within the BME Graduate Program is designed for students with an undergraduate degree in engineering, chemistry, physics, biochemistry, or related physical science. The Track emphasizes the development and application of cutting-edge imaging technologies, molecular imaging probes, and image processing techniques. Through coursework, seminars, journal clubs, and their own research, students in the BMI Track will be exposed to a wide range of traditional and emerging imaging methodologies.
The current BMI faculty consists of basic scientists, biomedical engineers, and clinicians interested in developing new imaging methodologies in both basic and clinical research at scales ranging from the molecular level to the whole body. Examples of current NIH-funded research projects include:
- Novel applications of noninvasive imaging including MRI, MRS, SPECT, PET, ultrasound, and optical imaging
- Functional brain imaging using fMRI and near infrared imaging (NIR)
- RF pulse sequence development for clinical MRI
- Metabolic imaging using isotope tracers and NMR spectroscopy
- MRI-guided high intensity focused ultrasound for tissue ablation and therapeutics
- Responsive MR agents and targeted PET agents for imaging biological function in vivo
- Molecular imaging of cancer using targeted nanoparticles
- Combinatorial chemistry to identify and image biological targets
A. Jeff Browning, M.D.
Research Interests: Nonalcoholic fatty liver disease (NAFLD) in humans
Shawn C. Burgess, Ph.D.
Research Interests: NMR spectroscopy and mass spectroscopy in conjunction with the application of stable isotope tracers to study metabolic function
Jeffrey Cadeddu, M.D.
Research Interests: Urology; laparoscopy, telesurgical mentoring
Changho Choi, Ph.D.
Research Interests: Development of spectral editing techniques for detection of key chemicals in the brain at 7T and 3T
Rajiv Chopra, Ph.D.
Research Interests: Development of MR guided high intensity focused ultrasound for preclinical and clinical imaging
Ian R. Corbin, Ph.D., M.Sc.
Research Interests: Molecular imaging techniques and nanomedicine technology development to better understand and characterize liver disease
Jinming Gao, Ph.D.
Research Interests: Activatable optical/MRI imaging probes to study tumor metabolism and theranostic nanomedicine for cancer-targeted drug therapy
Connie Hsia, M.D.
Research Interests: Heart-lung interaction; lung morphometry; structure-function correlation of lung growth
Hao Huang, Ph.D.
Research Interests: MRI, especially DTI technology, of brain structures and application of structural information to answer biological questions
Qui-Xing Jiang, Ph.D.
Research Interests: Lipid effects on voltage-gated ion channels, surface-engineering technology for imaging biological complexes of low abundance
Charlie Khemtong, Ph.D.
Research Interests: In vivo myocardial metabolism of rodent hearts using hyperpolarized 13C NMR to evaluate myocardial oxygen consumption
Zoltan Kovacs, Ph.D.
Research Interests: Generation and application of hyperpolarized 13C-labeled compounds and 89Y-complexes for MRI/Radiopharmaceutical applications
Padmaker Kulkarni, Ph.D.
Research Interests: Molecular Imaging, PET/SPECT, Alzheimer’s Imaging
Robert Lenkinski, Ph.D.
Research Interests: Clinical applications of in vivo MRS, Development of MR, radiotracer and optical based imaging contrast agents for imaging
Matthew Lewis, Ph.D.
Research Interests: Molecular imaging instrumentation, linear and nonlinear diffraction tomography, tensor tomography, applied inverse problems
Wen-Hong Li, Ph.D.
Research Interests: Engineering probes and assays for monitoring islet beta cell mass or function in vivo; Physiological regulation of hormone secretion in pancreatic islets; Functional analysis of microRNA.
Hanzhang Lu, Ph.D.
Research Interests: Development of MRI technologies to study human brain physiology and metabolism, Improvement of clinical diagnosis of brain disorders
Ananth Madhuranthakam, Ph.D.
Research Interests: Development of novel MR imaging techniques for whole-body cancer screening and staging
Mala Mahendroo, Ph.D.
Research Interests: Imaging extracellular matrix changes during cervical ripening
Craig Malloy, M.D.
Research Interests:13C MRS methods for measuring cardiac intermediary metabolism flux and function analysis, Neurotransmitter metabolism of human brain
Weihua Mao, Ph.D.
Research Interests: Tumor tracking and motion compensation in real-time; Personalized online adaptive radiation therapy; Heat-enhanced radiation therapy
Ralph P. Mason, Ph.D., C.Sci., C.Chem.
Research Interests: Tumor pathophysiology and MR assessment of prognostic biomarkers, hypoxia and pH
Roderick McColl, Ph.D.
Research Interests: fMRI; DICOM
Matthew E. Merritt, Ph.D.
Research Interests: MR hyperpolarization for NMR sensitivity enhancement, Metabolomics, Efficient NMR Data Reduction
Raimund Ober, Ph.D.
Research Interests: Single molecule microscopy; microscopy instrumentation; image analysis; biosensor data analysis; systems biology and modeling; antibody trafficking; FcRn; cancer biology and autoimmunity
Orhan K. Öz, M.D., Ph.D.
Research Interests: Application of structural (x-ray, CT and MR) and functional (SPECT and PET) imaging methods to quantify changes in bone mass and metabolism induced by metabolic bone diseases; In vivo assessment of beta cell mass and function by novel probes; Novel PET and SPECT probe development for bone cells
Ivan Pedrosa, M.D.
Research Interests: Development of novel MRI techniques for improved diagnosis of abdominal/pelvic diseases and noninvasive in-vivo assessment of physiology and response to therapy in tumors
Fangyu Peng, M.D., Ph.D.
Research Interests: Translational cancer imaging and therapy, including identification of new targets for molecular cancer imaging with PET-CT and targeted cancer therapy
Matthew Petroll, Ph.D.
Research Interests: Cell motility and mechanics, corneal repair and regeneration, in vivo confocal imaging
Neil Rofsky, M.D.
Research Interests: Translation of novel MR imaging methods (arterial spin labeling, diffusion, perfusion) to important problems in clinical medicine
Dean Sherry, Ph.D.
Research Interests: MRS studies of intermediary metabolism in intact tissues, Development of MRI molecular imaging agents
Rhonda Souza, M.D.
Research Interests: Internal Medicine/VAMC; investigate the molecular mechanisms involved in the development and neoplastic progression of Barrett’s esophagus, focusing on the intracellular signaling mechanisms and biologic relevance of acid and/or bile acid exposure, the components of reflux, on Barrett’s esophagus using animal models, cell culture, and human biopsy tissues
Xiankai Sun, Ph.D.
Research Interests: Development of PET, SPECT and MRI imaging probes to assess biological abnormalities and evaluation of disease treatment
Masaya Takahashi, Ph.D.
Research Interests: MRI of the lung, molecular imaging, myelin mapping, neuroimaging at ultra-high field MRI
D. Gomika Udugamasooriya, Ph.D.
Research Interests: Development and evaluation of classes of high affinity and specific multi-site binding ligands for cancer cells via a genome-wide targeted approach
Elena Vinogradov, Ph.D.
Research Interests: Endogenous and exogenous MRI contrast agents and mechanisms in-vivo, CEST and PARACEST imaging, hyperpolarization.
Takeshi Yokoo, M.D., Ph.D.
Research Interests: Applied mathematics and MRI methods for translational research in liver imaging with special focus of evaluation of Nonalcoholic Fatty Liver Disease (NAFLD).
Dawen Zhao, M.D., Ph.D.
Research Interests: Functional and molecular optical and MR imaging of tumor vasculature and its response to novel therapeutics in animal models of primary and metastatic brain tumors