Biomedical & Molecular Imaging Track

Dean Sherry, Ph.D.
Track Director

The Biomedical & Molecular Imaging Track within the BME Graduate Program is designed for students with an undergraduate degree in engineering, chemistry, physics, biochemistry, or related physical science. The Track emphasizes the development and application of cutting-edge imaging technologies, molecular imaging probes, and image processing techniques. Through coursework, seminars, journal clubs, and their own research, students in the BMI Track will be exposed to a wide range of traditional and emerging imaging methodologies.

The current BMI faculty consists of basic scientists, biomedical engineers, and clinicians interested in developing new imaging methodologies in both basic and clinical research at scales ranging from the molecular level to the whole body. Examples of current NIH-funded research projects include:

  • Novel applications of noninvasive imaging including MRI, MRS, SPECT, PET, ultrasound, and optical imaging
  • Functional brain imaging using fMRI and near infrared imaging (NIR)
  • RF pulse sequence development for clinical MRI
  • Metabolic imaging using isotope tracers and NMR spectroscopy
  • MRI-guided high intensity focused ultrasound for tissue ablation and therapeutics
  • Responsive MR agents and targeted PET agents for imaging biological function in vivo
  • Molecular imaging of cancer using targeted nanoparticles
  • Combinatorial chemistry to identify and image biological targets

Faculty

Shawn C. Burgess, Ph.D.
Research Interests: NMR spectroscopy and mass spectroscopy in conjunction with the application of stable isotope tracers to study metabolic function

Jeffrey Cadeddu, M.D.
Research Interests: Urology; laparoscopy, telesurgical mentoring

Changho Choi, Ph.D.
Research Interests: Development of spectral editing techniques for detection of key chemicals in the brain at 7T and 3T

Rajiv Chopra, Ph.D.
Research Interests: Development of MR guided high intensity focused ultrasound for preclinical and clinical imaging

Ian R. Corbin, Ph.D., M.Sc.
Research Interests: Molecular imaging techniques and nanomedicine technology development to better understand and characterize liver disease

Jinming Gao, Ph.D.
Research Interests: Activatable optical/MRI imaging probes to study tumor metabolism and theranostic nanomedicine for cancer-targeted drug therapy

Connie Hsia, M.D.
Research Interests: Heart-lung interaction; lung morphometry; structure-function correlation of lung growth

Hao Huang, Ph.D.
Research Interests: MRI, especially DTI technology, of brain structures and application of structural information to answer biological questions

Steve Jiang, Ph.D.
Research Interests:  Cloud and GPU-based high performance computing in medical physics and imaging; automatic radiotherapy treatment planning; adaptive radiotherapy; image guided radiotherapy; low-dose and dynamic cone beam CT

Qui-Xing Jiang, Ph.D.
Research Interests: Lipid effects on voltage-gated ion channels, surface-engineering technology for imaging biological complexes of low abundance

Eunsook Jin, Ph.D.

Romaine Johnson, M.D.
Training Track: Biomaterials, Mechanics and Tissue Engineering
Research Interests: Tissue engineering and regenerative medicine; biomaterials; biomechanics (tissue mechanics); airway regeneration and reconstruction.

Zoltan Kovacs, Ph.D.
Research Interests: Generation and application of hyperpolarized 13C-labeled compounds and 89Y-complexes for MRI/Radiopharmaceutical applications

Padmaker Kulkarni, Ph.D.
Research Interests: Molecular Imaging, PET/SPECT, Alzheimer’s Imaging

Robert Lenkinski, Ph.D.
Research Interests: Clinical applications of in vivo MRS, Development of MR, radiotracer and optical based imaging contrast agents for imaging

Matthew Lewis, Ph.D.
Research Interests: Molecular imaging instrumentation, linear and nonlinear diffraction tomography, tensor tomography, applied inverse problems

Wen-Hong Li, Ph.D.
Research Interests: Engineering probes and assays for monitoring islet beta cell mass or function in vivo; Physiological regulation of hormone secretion in pancreatic islets; Functional analysis of microRNA.

Hanzhang Lu, Ph.D.
Research Interests: Development of MRI technologies to study human brain physiology and metabolism, Improvement of clinical diagnosis of brain disorders

Ananth Madhuranthakam, Ph.D.
Research Interests: Development of novel MR imaging techniques for whole-body cancer screening and staging

Craig Malloy, M.D.
Research Interests: 13C MRS methods for measuring cardiac intermediary metabolism flux and function analysis, Neurotransmitter metabolism of human brain

Weihua Mao, Ph.D.
Research Interests: Tumor tracking and motion compensation in real-time; Personalized online adaptive radiation therapy; Heat-enhanced radiation therapy

Ralph P. Mason, Ph.D., C.Sci., C.Chem.
Research Interests: Tumor pathophysiology and MR assessment of prognostic biomarkers, hypoxia and pH

Roderick McColl, Ph.D.
Research Interests: fMRI; DICOM

Matthew E. Merritt, Ph.D.
Research Interests: MR hyperpolarization for NMR sensitivity enhancement, Metabolomics, Efficient NMR Data Reduction

Orhan K. Öz, M.D., Ph.D.
Research Interests: Application of structural (x-ray, CT and MR) and functional (SPECT and PET) imaging methods to quantify changes in bone mass and metabolism induced by metabolic bone diseases; In vivo assessment of beta cell mass and function by novel probes; Novel PET and SPECT probe development for bone cells

Ivan Pedrosa, M.D.
Research Interests: Development of novel MRI techniques for improved diagnosis of abdominal/pelvic diseases and noninvasive in-vivo assessment of physiology and response to therapy in tumors

Matthias Peltz, M.D.
Research Interests:

Fangyu Peng, M.D., Ph.D.
Research Interests: Translational cancer imaging and therapy, including identification of new targets for molecular cancer imaging with PET-CT and targeted cancer therapy

Matthew Petroll, Ph.D.
Research Interests: Cell motility and mechanics, corneal repair and regeneration, in vivo confocal imaging

Neil Rofsky, M.D.
Research Interests: Translation of novel MR imaging methods (arterial spin labeling, diffusion, perfusion) to important problems in clinical medicine

Dean Sherry, Ph.D.
Research Interests: MRS studies of intermediary metabolism in intact tissues, Development of MRI molecular imaging agents

Rhonda Souza, M.D.
Research Interests: Internal Medicine/VAMC; investigate the molecular mechanisms involved in the development and neoplastic progression of Barrett’s esophagus, focusing on the intracellular signaling mechanisms and biologic relevance of acid and/or bile acid exposure, the components of reflux, on Barrett’s esophagus using animal models, cell culture, and human biopsy tissues

Xiankai Sun, Ph.D.
Research Interests: Development of PET, SPECT and MRI imaging probes to assess biological abnormalities and evaluation of disease treatment

Masaya Takahashi, Ph.D.
Research Interests: MRI of the lung, molecular imaging, myelin mapping, neuroimaging at ultra-high field MRI

Elena Vinogradov, Ph.D.
Research Interests: Endogenous and exogenous MRI contrast agents and mechanisms in-vivo, CEST and PARACEST imaging, hyperpolarization.

Jing Wang, Ph.D.
Research Interests:

Takeshi Yokoo, M.D., Ph.D.
Research Interests: Applied mathematics and MRI methods for translational research in liver imaging with special focus of evaluation of Nonalcoholic Fatty Liver Disease (NAFLD).

Dawen Zhao, M.D., Ph.D.
Research Interests: Functional and molecular optical and MR imaging of tumor vasculature and its response to novel therapeutics in animal models of primary and metastatic brain tumors