Park Lab

Metabolic imaging using MR

MRI/MRS provide useful information of in vivo metabolism and tissue heterogeneity ranging from anatomical change to cellular metabolism.

Metabolic changes after cancer therapy

Hyperpolarized [1-¹³C]pyruvate can detect acute anti-VEGF treatment responses in glioma.

Branched-chain amino acids metabolism

Altered BCAA metabolism in glioma can be measured using hyperpolarized α-ketoisocaproic acid.

Cerebral TCA cycle activity

[2-¹³C]pyruvate allows in vivo assessment of mitochondrial metabolism.

Clinical translation

Multiple in-human studies are in progress in the lab.