Ilya B. Bezprozvanny, Ph.D.
Research Interests: Calcium channels and calcium signaling in the nervous system; deranged calcium signaling and neurodegeneration in Huntington's and Alzheimer's disease
James A. Bibb, Ph.D.
Research Interests: Signal transduction in the nervous system, with emphasis on the biochemistry and neuropharmacology of protein phosphorylation/dephosphorylation
Marc Diamond, M.D.
Research Interests: Mechanisms of amyloid propagation in neurodegenerative diseases, especially tauopathies (e.g. Alzheimer’s disease), synucleinopathies (e.g. Parkinson’s disease), and polyglutamine diseases (e.g. Huntington’s disease); linkage between amyloid structure and biological impact.
Jeffrey Elliott, M.D.
Research Interests: Molecular and cellular basis for function of the ALS disease gene SOD1
Woo-Ping Ge, Ph.D.
Research Interests: The goal of our lab is to understand the mechanisms underlying the interactions between the brain vasculature and the nervous system. Combining electrophysiology and in vivo imaging with genetic methods, our lab studies: (1) how a brain builds the gliovascular and neurovascular network during development; (2) how this network is damaged during strokes; and (3) how the network is repaired after strokes. Ultimately, this focus might lead to the development of novel therapeutic targets for treating stroke, which affects about 700,000 Americans each year.
Robert W. Greene, M.D., Ph.D.
Research Interests: Circuit dysfunction in psychiatric disorders; role of adenosine in function of sleep
Kimberly M. Huber, Ph.D.
Research Interests: Mechanisms of synapse development, plasticity and circuit function, and alterations of these processes in mouse models of mental retardation and autism
Jane E. Johnson, Ph.D.
Research Interests: Molecular control of neuronal diversity and balancing progenitor cell maintenance with neuronal differentiation in the vertebrate central nervous system implications for tumor progression in neural and neuroendocrine cancers
Genevieve Konopka, Ph.D.
Research Interests: Neurodevelopmental signaling pathways involved in cognition and neuropsychiatric disorders; comparative gene expression for insight into human brain evolution
Said Kourrich, Ph.D.
Research Interests: Experience-induced synaptic and intrinsic plasticity with a focus on exposure to drugs of abuse; Interaction between intrinsic and synaptic excitability in the shaping of global neuronal activity; Regulation of neuronal excitability by the endoplasmic chaperone protein sigma-1 receptor (Sig-1R)
Julian Meeks, Ph.D.
Research Interests: Mechanisms of sensory processing in mammalian olfaction; mechanisms of information transformation in neural circuits; reciprocal synapses; interneuron functional diversity; neural control of innate social/reproductive behaviors
Lisa Monteggia, Ph.D.
Research Interests: Elucidating antidepressant efficacy; functional molecular and behavioral approach to autism spectrum disorders; cellular basis of psychiatric disorders
Juan Pascual, M.D., Ph.D.
Rare Brain Disorders Lab
Research Interests: Animal and cellular models of neurogenetic disorders; synaptic transmission in experimental epilepsies; disorders of brain energy metabolism; developmental neurobiology; genotype:phenotype correlations in novel childhood encephalopathies; clinical pediatric neurology
Brad Pfeiffer, Ph.D.
Research Interests: Consolidation and recall of memory via large-scale, high-density in vivo recordings of neural activity during free behavior in rodents, focusing on spatial navigation as a specific example of more general memory formation and use.
Todd Roberts, Ph.D.
Research Interests: Cellular and circuit mechanisms for vocal imitation, learning from vocal models and using auditory feedback to learn from vocal practice
Adrian Rothenfluh, Ph.D.
Research Interests: Drug-induced behaviors in Drosophila to learn more about the genes, signaling pathways, and brain circuits mediating these behaviors, with the goal of gaining insights into vertebrate addiction
Ann Stowe, Ph.D.
Research Interests: Stroke; Neuroinflammation; endogenous mechanisms of CNS protection; clinical role of the immune system and growth factors in functional recovery after stroke
Kevin Williams, Ph.D.
Research Interests: Understanding at a cellular level the neural of control energy balance as well as glucose metabolism, and elucidating how these events may participate in human disease.
Jiang Wu, Ph.D.
Research Interests: Chromatin regulation of mammalian neural development; function of chromatin remodeling complexes in key signaling pathways that regulate neural stem cell self-renewal, differentiation, and post-mitotic neuronal development
Wei Xu, Ph.D.
Research Interests: Mechanistic understanding of fundamental cognitive processes including memory and brain executive controls whose dysfunction is implicated in multiple neuropsychiatry disorders
Masashi Yanagisawa, M.D., Ph.D.
Masashi Yanagisawa Lab
Research Interests: Identification and characterization of new neuropeptides that regulate vital functions such as sleep, appetite, and blood pressure.
Jeffrey Zigman, M.D., Ph.D.
Research Interests: The role of ghrelin in eating behaviors of various types: food intake to survive, eating for pleasure (reward-based eating), eating upon stress
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.
Janine Prange-Kiel, Ph.D.
Research Interests: Locally produced estradiol has been demonstrated to be important for the regulation of synaptic plasticity in the hippocampus. However, very little is known about the factors that regulate the expression of aromatase, the enzyme that converts testosterone into estradiol, in the brain. Our lab uses cell culture techniques and molecular approaches to learn more about the regulation of aromatase expression in the hippocampus of rats and mice.
Lenora Volk, Ph.D.
Research Interests: Elucidating the molecular, synaptic, and circuit mechanisms underlying memory persistence.