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Our Laboratory

Focuses on understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.

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Endoplasmic Reticulum Stress and the Unfolded Protein Response

We are particularly interested in these pathways within identified neurons and their potential role in the pathogenesis of obesity and diabetes

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Linking neuronal activity with energy and glucose balance

We are also interested in elucidating cellular mechanisms involved in the neuronal activity-dependent regulation of metabolism through a combination of genetic, biochemical, and molecular approaches.

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Anatomical and structural identification of the brain in metabolism

We use immunohistochemical and genetic strategies to identify neuronal components contributing to the regulation of metabolism.

Research

Our work has identified specific neural circuits and signaling mechanisms controlling feeding behaviors, energy expenditure, and glucose metabolism.

Lab Members

Members of the Williams Lab