Researchers at UT Southwestern Medical Center’s Hamon Center for Regenerative Science and Medicine identified that the depletion of the tumor suppressor retinoblastoma protein disrupted growth, survival and neuronal migration in human cerebral organoids. These results demonstrated that human cerebral organoids are a powerful tool with which to study human brain development in a dish. This work was published in Development Issue 144(6):1025-1034.
A new Twist in adult skeletal muscle growth and regeneration
Researchers at UT Southwestern Medical Center’s Hamon Center for Regenerative Science and Medicine identified an interstitial progenitor cell, characterized by Twist2 expression, that is highly myogenic, forms type IIb/x myofibres and contributes to regeneration in adult skeletal muscle. This work was published in Nature Cell Biology and featured in the News and Views entitled: “Twist of fate for skeletal muscle mesenchymal cells" written by Goloviznina & Kyba.