The Division of Pediatric Cardiothoracic Surgery is leading the following research projects:
Optimal Flow Rate for Selective Cerebral Perfusion
Selective cerebral perfusion has been employed to provide cerebral blood flow during the time of circulatory arrest for heart surgery. However, data of this technique is limited. In this study we are looking for the optimal temperature, flow rate, and pH strategy for selective cerebral perfusion during the deep hypothermic cardiopulmonary bypass, using a piglet model.
Preliminary Evaluation of a Novel Biodegradable Stent
Hybrid procedures, combining surgery and interventional catheterization, have been used in the treatment of complex congenital heart disease. The greatest issue is the stent that is a permanent implant placed in a newborn baby requiring complete surgical removal in the future. In this study, we will design a novel biodegradable stent to be used in a hybrid procedure. This specific project involves bench testing of the biodegradable stents and their performance in animal models.
Cardiac Tissue Engineering
Our strategy involves engineering biodegradable elastic 3D cardiac tissue with oxygen-releasing scaffolding sheets with embedded microchannels. Stacking multiple cell engineered sheets with aligned cellular architecture and vascularization might allow the production of thick, vascularized cardiac tissues. The microscale technology has been shown to generate cardiomyocytes in vitro which may then be incorporated into the 3D porous scaffolds.