Cell and Molecular Biology Faculty


Paul Sternweis, Ph.D.

Paul Sternweis, Ph.D., Program Chair
Research Interests: Regulation of intracellular events by cell-surface receptors; structure and function of GTP-dependent regulatory proteins and their effectors

Joseph Albanesi

Joseph Albanesi, Ph.D., Professor
Research Interests: Mechanisms of membrane fusion; role of lipids in membrane trafficking; membrane vesiculation of dynamin

Neal Alto

Neal Alto, Ph.D., Associate Professor
Alto Lab
Research Interests: The intersection between human signal-transduction and bacterial pathogenesis; use of biochemical and cell biological analysis to define molecular mechanisms of microbial infectious disease

James Bibb

James Bibb, Ph.D., Professor
Bibb Lab
Research Interests: Protein phosphorylation/dephosphorylation related to neural function

Dr. Michael Brown

Michael Brown, M.D., Professor
Brown-Goldstein Lab
Research Interests: Regulation of gene expression; cell-surface receptor function; genetics and biochemistry of lipoprotein and cholesterol metabolism

Cheng-Ming Chiang, Ph.D.

Cheng-Ming Chiang, Ph.D., Professor
Chiang Lab
Research Interests: Mechanisms of transcriptional regulation and epigenetic control; chromatin remodeling and histone tail modification; sumoylation and ubiquitination; functional interplay between oncoproteins and tumor suppressor proteins; general transcription factors and cofactors

Melanie Cobb, Ph.D.

Melanie Cobb, Ph.D., Professor
Cobb Lab
Research Interests: Protein kinase cascades; MAP kinases; signal-transduction mechanisms

James Collins, Ph.D.

James Collins, Ph.D., Assistant Professor
Collins Lab
Research Interests: Germ cells, immunology, parasite biology, pathogenesis, regeneration, stem cells

Maralice Conacci-Sorrell, Ph.D.

Maralice Conacci-Sorrell, Ph.D., Assistant Professor
Sorrell Lab
Research Interests: Cell migration, survival, stress response, cancer

Gaudenz Danuser, Ph.D.

Gaudenz Danuser, Ph.D., Professor
Danuser Lab
Research Interests: Live cell imaging and mathematical modeling of mechanical and chemical signal transduction; cytoskeleton regulation and mechanics

Russell DeBose-Boyd, Ph.D.

Russell DeBose-Boyd, Ph.D., Professor
DeBose-Boyd Lab
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism


Andreas Doncic, Ph.D., Assistant Professor
Doncic Lab
Research Interests: Systems biology, single-cell microscopy, cell-fate decision processes

Joseph Goldstein

Joseph Goldstein, M.D., Professor
Brown-Goldstein Lab
Research Interests: Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression

Joel Goodman, Ph.D.

Joel Goodman, Ph.D., Professor
Goodman Lab
Research Interests: Intracellular sorting of newly synthesized proteins; organelle biogenesis and membrane structure and function; the yeast peroxisome as a model of organellar assembly


Mike Henne, Ph.D., Assistant Professor 
Henne Lab
Research Interests: Molecular mechanisms of membrane sculpting; formation and dynamics of inter-organelle membrane contact sites (MCSs) in human health and disease


Jer-Tsong (J.T.) Hsieh, Ph.D., Professor
Research Interests: Human cancer gene therapy; signaling defects in urogenital cancers


Lily Huang, Ph.D., Associate Professor
Huang Lab
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer


Khuloud Jaqaman, Ph.D., Assistant Professor
Jaqaman Lab
Research Interests: Quantitative single-molecule imaging of receptor organization and signaling; linking molecular and cellular behavior across multiple scales; computational image analysis and data multiplexing


Steven Kliewer, Ph.D., Professor
Mangelsdorf-Kliewer Lab
Research Interests: Physiology of nuclear receptors


Mark Lehrman, Ph.D., Professor
Lehrman Lab
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease


Jen Liou, Ph.D., Assistant Professor
Research Interests: Spatial and temporal regulation of cellular signaling events; mechanisms and physiological roles of store-operated calcium signaling


James Malter, M.D., Professor
Malter Lab
Research Interests: Post-transcriptional gene regulation and signaling in the immune and nervous system


David Mangelsdorf, Ph.D., Professor
Mangelsdorf-Kliewer Lab
Research Interests: Mechanism of nuclear hormone receptor action; role of retinoids in cancer; transcriptional regulation of lipid metabolism


Denise Marciano, M.D., Ph.D., Assistant Professor
Marciano Lab
Research Interests: Regulation of cell-cell adhesion during tubule and glomerular formation and in polycystic kidney disease


Carole Mendelson, Ph.D., Professor
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression


John Minna, M.D., Professor
Minna Lab
Research Interests: Molecular genetics of human cancer; growth factors and signal transduction in human tumors


Prashant Mishra, M.D., Ph.D., Assistant Professor
Mishra Lab
Research Interests: Molecular mechanical force field development; virtual screenings for drug lead identification; Molecular dynamics simulations of protein folding and drug delivery; and rational protein design


Daniela Nicastro, Ph.D., Associate Professor
Nicastro Lab
Research Interests: Three-dimensional structures and functions of organelles and macromolecular complexes, with special emphasis on cytoskeletal assemblies and molecular motors


Gray Pearson, Ph.D., Assistant Professor 
Research Interests: Breast cancer; cell motility and invasion; epithelial-to mesenchymal transition; metastasis; tumor microenvironment


Kate Luby-Phelps, Ph.D., Professor
Electron Microscopy Core Facility
Research Interests: Light microscope imaging of structure and function in living cells and tissues


Rama Ranganathan, M.D., Ph.D., Professor
Ranganathan Lab
Research Interest: Biophysical mechanisms that underlie cellular signal transduction in sensory neurons


Michael Reese, Ph.D., Assistant Professor
Reese Lab
Research Interests: Biochemistry; biophysics; cell signaling, kinases, pseudokinases; host-pathogen interaction; co-evolution; immunology; structural biology


Daniel Rosenbaum, Ph.D., Assistant Professor
Rosenbaum Lab
Research Interests: Structure and mechanism of integral membrane signaling proteins


Elliott Ross, Ph.D., Professor
Ross Lab
Research Interests: Mechanisms and regulatory behavior of G-protein signaling; regulated protein-protein interactions in signal transduction


Michael Roth, Ph.D., Professor
Roth Lab
Research Interests: Recognition and sorting of cell-surface glycoproteins


David Russell, Ph.D., Professor
Russell Lab
Research Interests: Steroid and bile-acid metabolism; molecular genetics; gene regulation; protein structure-function


Philipp Scherer, Ph.D., Professor
Scherer Lab
Research Interests: Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis; inflammation and cancer; beta cell biology


Sandra Schmid, Ph.D., Professor
Schmid Lab
Research Interests: Mechanisms governing and regulation of clathrin-mediated endocytosis, structure and function of the GTPase dynamin


Joachim Seemann, Ph.D., Associate Professor
Seemann Lab
Research Interest: Biogenesis of the Golgi apparatus


Dean Smith, M.D., Ph.D., Professor
Smith Lab
Research Interest: Sensory transduction in Drosophila melanogaster


Vincent Tagliabracci, Ph.D., Assistant Professor
Tagliabracci Lab
Research Interests: Kinases in the secretory pathway and the extracellular space; secreted protein and peptide hormone phosphorylation; CRISPR/Cas9 genome editing


Lance Terada, M.D., Professor
Terada Lab
Research Interests: Vascular biology; oxidant biochemistry; signal transduction; acute lung injury


Dawn Wetzel, M.D., Ph.D., Assistant Professor
Wetzel Lab
Research Interests: Cellular and molecular pathogenesis of leishmaniasis and other parasitic infections; host-pathogen interactions; development of novel antiparasitics


Angelique Whitehurst, Ph.D., Assistant Professor
Whitehurst Lab
Research Interests: The role of ectopically activated gametogenic programs in supporting tumor cell proliferation and survival


Helen Yin, Ph.D., Professor
Yin Lab
Research Interest: Mechanisms for signal transduction through the actin cytoskeleton


Gang Yu, Ph.D., Professor
Yu Lab
Research Interests: Biochemistry of signal transduction, gene regulation, and membrane protein complexes; molecular and cellular mechanisms of neurogenesis, neuroplasticity, and neurodegeneration


Hongtao Yu, Ph.D., Professor
Yu Lab
Research Interest: Study of cell division cycle

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

Elizabeth Chen, Ph.D., Professor
Research Interests: Cell-cell fusion, actin cytoskeletal dynamics, muscle development and regeneration


Ronald Taussig, Ph.D., Associate Professor
Research Interest: G protein-mediated signaling