Cell and Molecular Biology Faculty
Paul Sternweis, Ph.D.
Research Interests: Regulation of intracellular events by cell-surface receptors; structure and function of GTP-dependent regulatory proteins and their effectors
Joseph Albanesi, Ph.D.
Research Interests: Mechanisms of membrane fusion; role of lipids in membrane trafficking; membrane vesiculation of dynamin
Neal Alto, Ph.D.
Research Interests: The intersection between human signal-transduction and bacterial pathogenesis; use of biochemical and cell biological analysis to define molecular mechanisms of microbial infectious disease
Steven Altschuler, Ph.D.
Research Interests: Design principles underlying the spatial-temporal organization of molecular networks
James Bibb, Ph.D.
Research Interests: Protein phosphorylation/dephosphorylation related to neural function
Michael Brown, M.D.
Research Interests: Regulation of gene expression; cell-surface receptor function; genetics and biochemistry of lipoprotein and cholesterol metabolism
Cheng-Ming Chiang, Ph.D.
Research Interests: Mechanisms of transcriptional regulation and epigenetic control; chromatin remodeling and histone tail modification; sumoylation and ubiquitination; functional interplay between oncoproteins and tumor suppressor proteins; general transcription factors and cofactors
Melanie Cobb, Ph.D.
Research Interests: Protein kinase cascades; MAP kinases; signal-transduction mechanisms
Russell DeBose-Boyd, Ph.D.
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism
Joseph Goldstein, M.D.
Research Interests: Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression
Joel Goodman, Ph.D.
Research Interests: Intracellular sorting of newly synthesized proteins; organelle biogenesis and membrane structure and function; the yeast peroxisome as a model of organellar assembly
F. Kent Hamra, Ph.D.
Research Interests: Signal transduction pathways that regulate stem cell development; application of sperm stem cells to biology and medicine
Jer-Tsong (J.T.) Hsieh, Ph.D.
Research Interests: Human cancer gene therapy; signaling defects in urogenital cancers
Lily Huang, Ph.D.
Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer
Khuloud Jaqaman, Ph.D.
Research Interests: Quantitative single-molecule imaging of receptor organization and signaling; linking molecular and cellular behavior across multiple scales; computational image analysis and data multiplexing.
Steve Jiang, Ph.D.
Steven Kliewer, Ph.D.
Research Interests: Physiology of nuclear receptors
Mark Lehrman, Ph.D.
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease
Jen Liou, Ph.D.
Research Interests: Spatial and temporal regulation of cellular signaling events; mechanisms and physiological roles of store-operated calcium signaling
James Malter, M.D.
Research Interests: Post-transcriptional gene regulation and signaling in the immune and nervous system.
David Mangelsdorf, Ph.D.
Research Interests: Mechanism of nuclear hormone receptor action; role of retinoids in cancer; transcriptional regulation of lipid metabolism
Denise Marciano, M.D., Ph.D.
Research Interests: Regulation of cell-cell adhesion during tubule and glomerular formation and in polycystic kidney disease
Carole Mendelson, Ph.D.
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression
John Minna, M.D.
Research Interests: Molecular genetics of human cancer; growth factors and signal transduction in human tumors
Gray Pearson, Ph.D.
Research Interests: Breast Cancer; Cell motility and invasion; Epithelial-to Mesenchymal Transition; Metastasis; Tumor microenvironment
Kate Luby-Phelps, Ph.D.
Research Interests: Light microscope imaging of structure and function in living cells and tissues
Ryan Potts, Ph.D.
Research Interests: Role of ubiquitin ligases in tumor initiation and progression, vesicular trafficking, and genome stability.
Rama Ranganathan, M.D., Ph.D.
Research Interest: Biophysical mechanisms that underlie cellular signal transduction in sensory neurons
Michael Reese, Ph.D.
Daniel Rosenbaum, Ph.D.
Research Interests: Structure and mechanism of integral membrane signaling proteins
Elliott Ross, Ph.D.
Research Interests: Mechanisms and regulatory behavior of G-protein signaling; regulated protein-protein interactions in signal transduction
Michael Roth, Ph.D.
Research Interests: Recognition and sorting of cell-surface glycoproteins
David Russell, Ph.D.
Research Interests: Steroid and bile-acid metabolism; molecular genetics; gene regulation; protein structure-function
Amit Sawant, Ph.D.
Philipp Scherer, Ph.D.
Research Interests: Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis; inflammation and cancer; beta cell biology
Sandra Schmid, Ph.D.
Research Interests: Mechanisms governing and regulation of clathrin-mediated endocytosis, structure and function of the GTPase dynamin
Joachim Seemann, Ph.D.
Research Interest: Biogenesis of the Golgi apparatus
Dean Smith, M.D., Ph.D.
Research Interest: Sensory transduction in Drosophila melanogaster
William Snell, Ph.D.
Research Interests: Cell-cell interactions and signal transduction during fertilization in Chlamydomonas; cellular and molecular mechanisms of cell-cell fusion
Ronald Taussig, Ph.D.
Research Interest: G protein-mediated signaling
Lance Terada, M.D.
Research Interests: Vascular biology; oxidant biochemistry; signal transduction; acute lung injury
Dawn Wetzel, M.D., Ph.D.
Research Interests: Cellular and molecular pathogenesis of leishmaniasis and other parasitic infections; host-pathogen interactions; development of novel antiparasitics.
Michael White, Ph.D.
Research Interests: Molecular mechanisms for control of cell growth and differentiation
Angelique Whitehurst, Ph.D.
Lani Wu, Ph.D.
Research Interest: Design principles underlying the formation of cellular polarity
Helen Yin, Ph.D.
Research Interest: Mechanisms for signal transduction through the actin cytoskeleton
Gang Yu, Ph.D.
Research Interests: Biochemistry of signal transduction, gene regulation, and membrane protein complexes; molecular and cellular mechanisms of neurogenesis, neuroplasticity, and neurodegeneration
Hongtao Yu, Ph.D.
Research Interest: Study of cell division cycle
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.