G protein-coupled receptors (GPCRs) are the largest human membrane protein family. These receptors play a diverse role in numerous physiological processes and possess "druggable" sites making them an attractive pharmacological target.
Activation of free fatty acid receptor 4 (FFAR4; aka GPR120) by omega-3 fatty (ω3-FAs) acids or synthetic agonists inhibit inflammatory signaling in macrophages, whereas FFAR4-mediated Gq/11 signaling in adipocytes stimulates glucose uptake.
High Fat Diet induces a large increase in macrophage infiltration into adipose tissue.
