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The Druggable GPCRome

G protein-coupled receptors (GPCRs) are the largest human membrane protein family. These receptors play a diverse role in numerous physiological processes and possess "druggable" sites making them an attractive pharmacological target. 

 
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FFAR4 Signaling Pathways

Activation of free fatty acid receptor 4 (FFAR4; aka GPR120) by omega-3 fatty (ω3-FAs) acids or synthetic agonists inhibit inflammatory signaling in macrophages, whereas FFAR4-mediated Gq/11 signaling in adipocytes stimulates glucose uptake. 

 
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Macrophage Infiltration into Adipose Tissue on High Fat Diet 

High Fat Diet induces a large increase in macrophage infiltration into adipose tissue. 

 
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Molecular Docking of Ligands to GPR92