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James Brugarolas, MD, PhD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
james.brugarolas@utsouthwestern.edu
To make an appointment, call 214-645-8300.
Biography
Dr. James Brugarolas received his M.D. degree in 1993 from the University of Navarra, Spain, and his Ph.D. in 1998 from the Massachusetts Institute of Technology. As a graduate student Dr. Brugarolas worked in the laboratory of Dr. Tyler Jacks exploring mechanisms of cellular transformation. Subsequently, Dr. Brugarolas did an Internship and Residency in Internal Medicine at Duke University Medical Center (1998-2001) and a Fellowship in Oncology at the Dana-Farber Cancer Institute (2001-2003). In 2002, he joined the laboratory of Dr. William G. Kaelin, where he initiated a new line of research to study the function of the TSC1/TSC2 tumor suppressor complex in hypoxia signaling. In 2003, Dr. Brugarolas was promoted to Instructor at Harvard Medical School. He is the recipient of the Dana-Farber Cancer Institute Claudia Adams Barr award for Innovative Basic Cancer Research (2003) and the Department of Medicine Young Investigator Award (2004). In 2006, Dr. Brugarolas became an Assistant Professor at U.T. Southwestern Medical Center, where he is the 2006 Virginia Murchison Linthicum Endowed Scholar in Medical Research. While primarily a laboratory based investigator, Dr. Brugarolas also sees patients in the clinic. The mission of the Brugarolas lab is: 1. To contribute to the development of new cancer treatment paradigms established upon a greater understanding of the molecular genetics and biology of tumors that exploit tumor plasticity and the principle of synthetic lethality. 2. To establish better preclinical models that recapitulate the behavior of cancer in patients and that can be harnessed in developmental therapeutic programs. 3. To contribute to the training of scientists and physician-scientists. This lab seeks to attract highly motivated individuals who are interested in cancer biology. The lab is particularly suited for ambitious graduate students and postdocs committed to pursuing a career in Academia, who enjoy a highly interactive environment and have a desire to excel.
Education
| Fellowship | Dana-Farber Cancer Institute - Medical Director, Medical Oncology (2003) |
| Internship | Duke University - Medicine Internship, Internal Medicine (2001) |
| Residency | Duke University - Medicine Residency, Internal Medicine (2001) |
| Graduate School | Massachusetts Institute of Technology (1998) |
| Medical School | Universidad de Navarra (1993) |
Research Interests
Publications
Kucejova B, Sunny NE, Nguyen AD, Hallac R, Fu X, Pena-Llopis S, Mason RP, Deberardinis RJ, Xie XJ, Debose-Boyd R, Kodibagkar VD, Burgess SC, Brugarolas J. , Oncogene , May 2011; (30(18)):2147-60
Brugarolas J , N Engl J Med , January 2007; (356(2)):185-7
Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J, , 2011 Jul 29; (30(16)):3242-58
Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J. , Mol Cell Biol , May 2011; (31(9)):1870-84
Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J. , Nat Rev Urol , March 2011; (8(3)):165-71
Kucejova B, Peña-Llopis S, Yamasaki T, Sivanand S, Tran TA, Alexander S, Wolff NC, Lotan Y, Xie XJ, Kabbani W, Kapur P, Brugarolas J, Molecular cancer research : MCR, 2011 Sep; 9 (9):1255-65
Kinch L, Grishin NV, Brugarolas J, Cancer cell, 2011 Oct; 20 (4):418-20
Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, Zhang X, Biochemistry, 2010 Mar; 49 (11):2491-501
Related Links
Honors/Awards
American Cancer Society (2008)
March of Dimes (2007)
Doris Duke Charitable Foundation (2007)
The V Foundation for Cancer Research (2007)
UT Southwestern Medical School (2006)