Recent Publications

The publications represent experiments conducted by the HTS Shared Resource.

Salahudeen, A.A., J.W. Thompson, J.C. Ruiz, H-W. Ma, L.N. Kinch, Q. Li, N.V. Grishin, R.K. Bruick. An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis. 2009. Science 326:722-726.

Qi, X., L. Wang and F. Du. Biochemistry 2010. Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1. Biochemistry 49:1923-30.

Chew, S.K., P. Chen, N. Link, K.A. Galindo, K. Pogue, and J.M. Abrams. 2009. Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature 460:123-128. PMID: 19483676

He, S., L. Wang, L. Miao, T. Wang, F. Du, L. Zhao, and X. Wang. 2009. Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-alpha. Cell, Volume 137, 1100-1111. PMID: 19524512

Chen, B., M. Dodge, W. Tang, J. Lu, Z. Ma, C-W. Fan, S. Wei, W. Hao, J. Kilgore, N. Williams, M. G. Roth, J. Amatruda, C. Chen and L. Lum. 2009. Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer. Nature Chem. Biol. 5:100-107. PMID: 19125156

Ganesan, A. K., H. Ho, B. Bondermann, S. Petersen, S. Koshy, J. Aruri, Z. Richardson, L. Q. Le, T. Krasieva, M. G. Roth, P. Farmer and M. A. White. Genome-wide siRNAi-based functional genomics of pigmentation identifies regulatory networks governing melanogenesis in human cells. 2008. PLOS genetics, e1000298. PMID: 19057677

Phillips, M.A., Gujjar, R., Malmquist, N.A., White, J., El Mazouni, F., Baldwin, J. and Rathod, P.K. 2008. Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum, J. Med. Chem., 26;51(12):3649-53. PMID: 18522386

Phillips, M.; Rathod, P. K.; Baldwin, J.; Gujjar, R. 2008 Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity. WO Patent 2007149211 A1, 2007. US Patent 20080027079 A1.

Rasko, D. A. C. G. Moreira, D. Li, J. M. Ritchie, M. K. Waldor, N. Williams, R. Taussig, C. Mischnoff, S. Wei, M. G. Roth, D. T. Hughes, J. Huntley, J. R. Falck, and V. Sperandio. 2008. Targeting QseC Signaling and Virulence for Antibiotic Development. Science, 321:1078-1080. PMID: 18719281

Roth, M. G., B. M. A. Fontoura, S. Wei, and N. Satterly. 2008. "NS1 Protein Inhibitors" US Patent Application No. 61/005,876.

Sadek H, Hannack B, Choe E, Wang J, Latif S, Garry MG, Garry DJ, Longgood J, Frantz DE, Olson EN, Hsieh J, Schneider JW. 2008. Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc. Natl. Acad. Sci. 0711507105. PMID: 18420817

Schneider, J.W., Z. Gao, S. Li, M. Farooqi, T.S. Tang, I. Bezprozvanny, D.E. Frantz, and J. Hsieh. 2008. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 4:408-10. PMID: 18552832

Tang, W., M. Dodge, D. Gundapaneni, C. Michnoff, M. G. Roth and L. Lum. 2008. A genome-wide RNAi screen for mammalian Wnt/beta-catenin pathway components identifies novel roles for TCF transcription factors in tumorigenesis. Proc. Natl. Acad. Sci. USA. 105:9709-9714. PMID: 18621708

Chen, X.; Longgood, J. C.; Michnoff, C.; Wei, S.; Frantz, D. E.; Bezprozvanny, I. 2007. High-Throughput Screen for Small Molecule Inhibitors of Mint1-PDZ Domains. Assay and Drug Development Technologies. 5:769-784. PMID: 18078379

Whitehurst, A. W., B. O. Bodemann, J. Cardenas, D. Ferguson, L. Girard, M. Payton, J. D. Minna, C. Michnoff, W. Hao, M. G. Roth, X.-J. Xie, and M. A. White. 2007. Synthetic Lethal Screen Identification of Chemosensitizer Loci in Cancer Cells. Nature, 446:815-819. PMID: 17429401

Baldwin, J., C. H. Michnoff, N. A. Malmquist, J. White, M. G. Roth, P. K Rathod and M. A. Phillips. 2005. High-throughput screening for potent and selective inhibitors of Plasmodiumn falciparum dihyrdroorotate dehydrogenase. J. Biol. Chem. 280: 21847-21853. PMID: 15795226