Cell Biology Faculty and Research
The Abrams Lab examines molecular networks that regulate cell death and explores how chromatin topology controls gene activity.
Our lab focuses on how cancer cells develop the ability to survive stress conditions such as nutrient deprivation and chemotherapy. We use animal models and molecular biology approaches to identify molecular switches that control stress response and we investigate how cancer cells exploit these switches to develop survival skills.
We study how mechanical and chemical signals integrate in space and time to control cytoskeleton dynamics and membrane trafficking. We develop a minimally-perturbing experimental approach that exploits the intrinsic heterogeneity of cell dynamic states to probe the hierarchy and kinetics of mechanochemical signaling cascades.
Our lab is interested in a fundamental question in life sciences: How do cells make decisions? To answer this question we have developed a framework that combines single-cell microscopy, genetic manipulation, and mathematical modeling. We use this framework to determine principles that govern cell fate decisions in budding yeast.
The Fiolka lab extends the current imaging capabilities of optical microscopy such that cancer cell research and drug screening can be performed in physiologically relevant, 3D environments, ex vivo and in vivo. The microscope development is focused on improving the spatiotemporal resolution and optical penetration depth and translating the new technologies to biological research
Our laboratory studies the cell biology of viral-host interactions. Our main focus is on the interplay between RNA viruses, such as influenza A and vesicular stomatitis viruses, and nuclear processes. We investigate interactions of virulence factors with RNA processing and nucleo-cytoplasmic trafficking, which regulate viral replication and antiviral response.
We use fibroblasts interacting with 3D collagen as a model of fibrous connective tissue to learn about cell behavior in a tissue-like environment. Our research focuses on motile and mechanical interactions between cells and matrix. We analyze these interactions at global and subcellular levels to understand the impact of cell-matrix tension state on cell morphology and mechanical behavior.
Our lab studies how cellular membranes are sculpted during processes like vesicle budding, organelle biogenesis, and the formation of inter-organelle membrane contact sites. We employ both budding yeast and mammalian cell systems to reveal molecular mechanisms of this membrane remodeling, and our main projects use combinations of cell biology, genetics, biochemistry, and structural biology to deeply understand cellular sculpting events.
Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.
Our research is two-fold: We study mechanisms regulating hormone release in the islets of Langerhans and to develop techniques to monitor changes of islet beta cell mass or function in vivo. We also perform functional analysis of microRNAs by identifying their target genes in a defined biological context.
Our lab studies the role of adaptor proteins on plasma membrane function in the context of endocytosis and cellular signaling.
Our lab studies why cells utilize primary cilia to organize signaling, and how extracellular inputs are spatio-temporally integrated by these compartments. Studying ciliary signaling also provides a more general paradigm for studying cellular sensory networks in regulating developmental pathways, and disease pathologies.
Our lab studies 3D structures and cell biological functions of macromolecular complexes inside cells, such as molecular motors, microtubules in cilia, and cancer-related nuclear proteins.
We study the mechanisms that govern and regulate clathrin-mediated endocytosis using biochemistry, biophysics, molecular cell biology and quantitative live-cell fluorescence microscopy.
We study the molecular mechanisms governing the function and inheritance of complex cellular organelles. In particular, we are investigating how the single Golgi apparatus is partitioned by the spindle machinery in mitosis as well as the regulatory role of the Golgi in organizing polarity during cell migration.
The Shay/Wright Lab studies the role of telomere biology in aging and cancer, the molecular mechanism of telomere replication and telomerase action, and how to translate these into clinical applications.