Recent Publications from AIRC Staff and Collaborators

  • Noninvasive monitoring of lactate dynamics in human forearm muscle after exhaustive exercise by (1) H-magnetic resonance spectroscopy at 7 tesla, J Ren J, A Dean Sherry & CR Malloy, Magn Reson Med., 70, 610-9 (2013).
  • Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM. Cell, 159, 1603-14 (2014).
  • In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T. Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, DeBerardinis RJ, Bachoo RM & Maher EA., Magn Reson Med, 72, 316-23 (2014). 
  • Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate  transport, Yang C Yang , B Ko, CT Hensley, L Jiang, AT Wasti, J Kim, JSudderth, MA Calvaruso,  L Lumata, M Mitsche, J Rutter, ME Merritt  & RJ DeBerardinis, Mol Cell., 56, 414-24 (2014).
  • Amplification of the effects of magnetization exchange by 31P band inversion for measuring adenosine, triphosphate synthesis rates in human skeletal muscle, J Ren, AD Sherry & CR Malloy, Magn Reson Med., 2014 Dec 2. doi: 10.1002/mrm.25514. [Epub ahead of print] (2014).
  • Hyperpolarized 13C NMR Detects Rapid Drug-induced Changes in Cardiac Metabolism,   C Khemtong, NR Carpenter, LL Lumata, ME Merritt, KX Moreno, Z Kovacs, CR Malloy & AD Sherry, Magn Reson Med., 2014 Aug 28. doi: 10.1002/mrm.25419. [Epub ahead of print] (2014).
  • Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function, A Comment & ME Merritt ME, Biochemistry, 53, 7333-57 (2014).
  • Propionate Stimulates Pyruvate Oxidation in the Presence of Acetate, C Purmal, B Kucejova, AD Sherry, SC Burgess, CR Malloy & ME Merritt,  Am J Physiol Heart Circ Physiol.,307, H1134-41 (2014)
  • Quadrature transmit coil for breast imaging at 7 tesla using forced current excitation for improved homogeneit, MP McDougall, S Cheshkov, J Rispoli, C Malloy, I Dimitrov & SM Wright, J Magn Reson Imaging, 40, 1165-73 (2014).
  • Real-time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone. KX Moreno, S Satapati, RJ DeBerardinis, SC Burgess, CR Malloy & ME Merritt, J Biol Chem., 289, 35859-67 (2014).
  • Reproducibility and absolute quantification of muscle glycogen in patients with glycogen storage disease by 13C NMR spectroscopy at 7 tesla, K Heinicke, IE Dimitrov, N Romain, S Cheshkov, J Ren, CR Malloy & RG Haller, PLoS ONE, 9, e108706 (2014). 
  • Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7T,  Ganji SK, An Z, Banerjee A, Madan A, Hulsey KM & Choi C.  NMR in Biomedicine, 27, 1167-1175. (2014)
  • Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion, ML Cobert, ME Merritt, LM West, C Ayers, ME Jessen &  M Peltz, Journal of Thoracic and Cardiovascular Surgery, 148, 2310-2315 (2014).
  • Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3T in vivo.   Madan A, Ganji SK, An Z, Choe K, Pinho M, Bachoo, RM, Maher EM & Choi C.  Magnetic Resonance in Medicine [Epub ahead of print] DOI: 10.1002/mrm.25352 - Accepted (2014).
  • In vivo 1H MRSI of glycine in brain tumors at 3T.  SK Ganji, EA Maher & C Choi. Magnetic Resonance in Medicine, DOI 10.1002/mrm.25588 (Epub ahead of print - Accepted 2014).
  • A roadmap for interpreting (13)C metabolite labeling patterns from cells,  JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, CB Clish, RJ DeBerardinis, O Feron, C Frezza, B Ghesquiere, E Gottlieb, K Hiller K, RG Jones, JJ Kamphorst, RG Kibbey, AC Kimmelman, JW Locasale, SY Lunt, OD Maddocks, C Malloy, CM Metallo, EJ Meuillet, J Munger, K Nöh, JD Rabinowitz, M Ralser, U Sauer, G Stephanopoulos, J St-Pierre, DA Tennant, C Wittmann, MG Vander Heiden, A Vazquez, K Vousden, JD Young, N Zamboni, SM Fendt,  Curr Opin Biotechnol., 34, 189-201 (2015). 
  • A simple approach to evaluate the kinetic rate constant for ATP synthesis in resting human skeletal muscle at 7 T, J Ren, AD Sherry & CR Malloy, NMR in Biomedicine, 2015 May 6. doi: 10.1002/nbm.3310. [Epub ahead of print] (2015).
  • A switched-mode breast coil for 7 tesla MRI using forced-current excitation. J Cui, J Bosshard, J Rispoli, I Dimitrov, S Cheshkov, M McDougall, C Malloy & Wright S.  IEEE Trans Biomed Eng. 2015 Feb 19. [Epub ahead of print] PubMed (2015).
  • Basic MR Relaxation Mechanisms & Contrast Agent Design. LM De León-Rodríguez, AF Martins, MC Pinho MC, NM Rofsky & AD Sherry, J Magn Reson Imaging. 2015 May 14. doi: 10.1002/jmri.24787. [Epub ahead of print] (2015).
  • Conditions for 13C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas, K Pichumani, T Mashimo, HM Baek, J Ratnakar, B Mickey, RJ DeBerardinis, EA Maher, RM Bachoo, CR Malloy & Z Kovacs , Anal Biochem, 2015 Apr 20. pii: S0003-2697(15)00180-3. doi: 10.1016/j.ab.2015.04.017. [Epub ahead of print] (2015).
  • Exchange kinetics by inversion transfer: Integrated analysis of the phosphorus metabolite kinetic exchanges in resting human skeletal muscle at 7 T, J Ren, B Yang, Sherry &  CR Malloy, Magn Reson Med., 73, 1359-69 (2015).
  • Hyperpolarized (15)N-pyridine Derivatives as pH-Sensitive MRI Agents, W Jiang, L Lumata, W Chen, S Zhang, Z Kovacs, AD Sherry, & C Khemtong, Sci Rep., 5, 9104 (2015).
  • Influence of Liver Triglycerides on Suppression of Glucose Production by Insulin in Men, ES Jin, M Szuszkiewicz-Garcia, JD Browning, JD Baxter, N Abate & CR Malloy, Men. J Clin Endocrinol Metab., 100, 235 - 243 (2015).
  • Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-13 C] acetate, SC Burgess, ME Merritt, JG Jones, JD Browning, AD  Sherry & CR Malloy, Nature Medicine, 21, 108-9 (2015).
  • Molecular platform for design and synthesis of targeted dual-modality imaging probes, A Kumar A, S Zhang, G Hao, G Hassan, S Ramezani, K Sagiyama, ST Lo, M Takahashi, AD Sherry, OK Öz OK, Z Kovacs & X Sun, Bioconjug Chem., 26: 549-58 (2015).
  • Numerical Analysis of Correlations between the NMR Chemical Shifts of Hyperpolarized 89Y Complexes and their Chemical Structures, Y Xing, AK Jindal, P Zhao, Z Kovacs & AD Sherry, in preparation
  • The ratio of acetate-to-glucose oxidation in astrocytes from a single (13) C NMR spectrum of cerebral cortex.  I Marin-Valencia, MA Hooshyar, K Pichumani, AD Sherry, & CR Malloy, J Neurochem., 132, 99-109 (2015).
  • Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production, KX Moreno, CL Moore, SC Burgess, AD Sherry, CR Malloy & ME Merritt, Metabolomics, in press (2015).
  • Influence of Available Substrates on Pathways of 13CO2 Production from Hyperpolarized [1-13C]pyruvate in Mouse Liver,  New title? KX Moreno, C Moore, SC Burgess, AD Sherry, CR Malloy & ME Merritt, J Biol Chem., submitted (2015).