Takeshi Yokoo, M.D., Ph.D.
In clinical Magnetic Resonance (MR) imaging, the cross-sectional images of the body are reconstructed by measuring the MR signals of the hydrogen atoms in various biological molecules and by mapping out their spatial location within the body.
Understanding the basic mechanism of how these signals are generated and how they behave in normal and pathologic conditions provides new insights into the development of quantitative techniques for detecting and characterizing pathology.
My research interest is in the development and validation of quantitative MR imaging techniques for clinical applications. Specifically, I am interested in MR techniques for accurate and precise noninvasive estimation of fat, iron, fibrosis, and inflammation in the liver.
Our team’s approach is to optimize the image acquisition techniques for a specific pathologic feature, develop appropriate MR signal model, and estimate the model parameters by fitting the model to imaging data. Following the bench-to-bedside trajectory of translational research, we validate our techniques using mathematical simulation (theory), phantom experiments (in vitro), animal experiments (in vivo), and ultimately in human subjects (clinical trial).
- Image analysis, signal processing
- Computational and quantitative imaging
- Magnetic Resonance Imaging and Spectroscopy
- Liver Imaging