Ananth Madhuranthakam, Ph.D.
Dr. Madhuranthakam’s research interests focus on the development of novel techniques to improve the clinical utility of magnetic resonance imaging (MRI). His laboratory specializes in understanding and applying MR Physics to exploit the variations in human anatomy and physiology to develop these novel techniques. The Madhuranthakam Lab has developed a number of these techniques that are being used in routine clinical practice.
A major area of focus is on developing whole body MR screening techniques. The state of the art screening techniques include PET/CT that uses ionizing radiation or MRI using diffusion-weighted echo planar imaging (DW-EPI) that are prone to image distortions. Dr. Madhuranthakam’s group is developing alternative techniques using Fast Spin Echo (FSE) that provides images with high signal to noise ratio, increased tumor conspicuity and minimal image distortions. This technique can be routinely used on patients for cancer screening and staging (for treatment follow-up) any number of times without the concerns of exposing them to the ionizing radiation.
Another area of research is breast imaging with emphasis on choline imaging. Current imaging techniques are unable to differentiate malignant from benign lesions on MRI, which leads to an increased number of unnecessary biopsies. Choline has been observed as a biomarker that increases in malignant lesions compared to benign lesions. Thus, choline imaging could differentiate malignant from benign lesions and decrease the number of unnecessary biopsies. It can also help to monitor the response to neoadjuvant chemotherapy, as early as 24 hours after treatment.
The majority of their research is conducted on whole body 3T human scanners. In addition, they are also exploring new techniques on high-field 7T whole body human scanner. In particular, they are designing new pulse sequences to reduce specific absorption rate (SAR) and improve the uniformity of images at 7T.
- Whole Body Cancer Screening
- MR Angiography
- Breast Imaging
- High Field (7T) Imaging
For publication information please view Dr. Madhuranthakam's faculty profile.