Biological Chemistry Faculty
Benjamin Tu, Ph.D.
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast
Richard Bruick, Ph.D.
Research Interests: Regulation of the mammalian hypoxic response pathway
Jef De Brabander, Ph.D.
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode of action, using molecular pharmacology and biochemistry
Ivan D'Orso, Ph.D.
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV
Marie-Alda Gilles-Gonzalez, Ph.D.
Research Interests: Mechanisms of O2, CO and NO sensing and in novel signal-transduction heme proteins
Bethany Janowski, Ph.D.
Research Interests: Gene regulation by small RNAs
Mark Lehrman, Ph.D.
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease
Wen-Hong Li, Ph.D.
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multi-photon fluorescence microscopy; mechanisms and functions of cellular calcium signaling
Qinghua Liu, Ph.D.
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease
John MacMillan, Ph.D.
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry
Anthony Michael, Ph.D.
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes
Deepak Nijhawan, M.D., Ph.D.
Research Interests: Using chemistry to identify new cancer drug targets
Margaret Phillips, Ph.D.
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites
Arun Radhakrishnan, Ph.D.
Research Interests: Protein-lipid interactions at membrane interfaces
Diana Tomchick, Ph.D.
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques
Gomika Udugamasooriya, Ph.D.
Research Interests: Development of high affinity and specific peptidomimetics (e.g., peptoids); targeting specific cell surface receptors at a genome-wide approach for early detection and treatment of cancer
Kosaku Uyeda, Ph.D.
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells
Kenneth Westover, M.D., Ph.D.
Research Interests: Cancer biology and development of new therapeutic drugs
Noelle Williams, Ph.D.
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders
Yonghao Yu, Ph.D.