Biological Chemistry Faculty
Benjamin Tu, Ph.D., Chair
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast
Richard Bruick, Ph.D.
Research Interests: Regulation of the mammalian hypoxic response pathway
Igor Butovich, Ph.D.
Research Interests: Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade
Chuo Chen, Ph.D.
Research Interests: Natural product synthesis, synthetic methodology development, small molecule library synthesis and chemical biology
David Chuang, Ph.D.
Research Interests: Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding
Nicholas Conrad, Ph.D.
Research Interests: Gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpes virus
David Corey, Ph.D.
Research Interests: Engineering proteins and nucleic acids for novel function
Russell DeBose-Boyd, Ph.D.
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism
Jef De Brabander, Ph.D.
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode of action, using molecular pharmacology and biochemistry
Ivan D'Orso, Ph.D.
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of
viral and human transcription complexes; mechanisms of transcription activation in HIV
George DeMartino, Ph.D.
Research Interests: Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases
J.R. Falck, Ph.D.
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry
Marie-Alda Gilles-Gonzalez, Ph.D.
Research Interests: Mechanisms of O2, CO, and NO sensing and in novel signal-transduction heme proteins
John Hulleman, Ph.D.
Research Interests: Protein misfolding diseases, stress-responsive signaling, chemical biology, high-throughput screening, drug discovery, age-related macular degeneration, retinal dystrophies
Jennifer Kohler, Ph.D,
Research Interests: Understanding and exploiting the molecular foundations of glycoconjugate Biosynthesis
Mark Lehrman, Ph.D
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease
Wen-Hong Li, Ph.D.
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multiphoton fluorescence microscopy; mechanisms and functions of cellular calcium signaling
Qinghua Liu Ph.D.
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease
Weibo Luo, Ph.D.
Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis
John MacMillan, Ph.D.
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry
Steven McKnight, Ph.D.
Research Interests: Molecular genetics and biochemical studies of mammalian gene regulation
Carole Mendelson, Ph.D.
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression
Anthony Michael, Ph.D.
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes
Peter Michaely, Ph.D.
Research Interests: Biochemical and structural study of receptor-mediated endocytosis and the membrane skeleton of the plasma membrane
Hamid Mirzaei, Ph.D.
Research Interests: Aging, drug discovery, neurodegeneration, proteomics
Yunsun Nam, Ph.D.
Research Interests: Mechanisms of RNA-mediated gene regulation; Structural and biochemical studies of RNA function
Deepak Nijhawan, M.D., Ph.D.
Research Interests: Using chemistry to identify new cancer drug targets
Kim Orth, Ph.D.
Research Interests: Signal transduction in the microbial pathogen Yersinia pestis
Steven Patrie, Ph.D.
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics
Margaret Phillips, Ph.D.
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites
Arun Radhakrishnan, Ph.D.
Research Interests: Protein-lipid interactions at membrane interfaces
Joseph Ready, Ph.D.
Research Interests: Discovery and application of new chemical reactions; total synthesis of complex molecules
Daniel Siegwart, Ph.D.
Research Interests: Polymer and materials chemistry, drug and gene delivery, RNAi, biomedical imaging, detection and treatment of cancer
Vanessa Sperandio, Ph.D.
Research Interests: Quorum sensing in enteropathogenic Escherichia coli
Uttam Tambar, Ph.D.
Research Interests: Synthesis of complex biologically active natural products; development of new tandem methodologies
Diana Tomchick, Ph.D.
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques
Kosaku Uyeda, Ph.D.
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells
Kenneth Westover, M.D., Ph.D.
Research Interests: Cancer biology and development of new therapeutic drugs
Noelle Williams, Ph.D.
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders
Jin Ye, Ph.D.
Research Interests:Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis
Yonghao Yu, Ph.D.
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation, and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modifications, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.
Qing Zhong, M.D., Ph.D.
Research Interests: Biochemical mechanisms of mammalian autophagy; autophagy regulated primary ciliogenesis; and programmed cell death