Biological Chemistry Faculty
Benjamin Tu, Ph.D., Chair
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast
Jef De Brabander, Ph.D.
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode of action, using molecular pharmacology and biochemistry
Ivan D'Orso, Ph.D.
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of
viral and human transcription complexes; mechanisms of transcription activation in HIV
J.R. Falck, Ph.D.
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry
Marie-Alda Gilles-Gonzalez, Ph.D.
Research Interests: Mechanisms of O2, CO, and NO sensing and in novel signal-transduction heme proteins
John Hulleman, Ph.D.
Research Interests: Protein misfolding diseases, stress-responsive signaling, chemical biology, high-throughput screening, drug discovery, age-related macular degeneration, retinal dystrophies
Wen-Hong Li, Ph.D.
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multiphoton fluorescence microscopy; mechanisms and functions of cellular calcium signaling
Qinghua Liu Ph.D.
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease
Jacques Lux, Ph.D., Assistant Professor
Research Interests: Polymeric materials for imaging (MRI, PET, CT nanoprobes) and theranostics; targeted and activatable ultrasound (US) agents for the detection of cancer
John MacMillan, Ph.D.
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry
David McFadden, M.D., Ph.D.
Research Interests: Genetically-engineered mouse models of cancer, chemical and genetic screens for new vulnerabilities in small cell lung cancer and Ewing sarcoma
Anthony Michael, Ph.D.
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes
Deepak Nijhawan, M.D., Ph.D.
Research Interests: Using chemistry to identify new cancer drug targets
Steven Patrie, Ph.D.
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics
Kosaku Uyeda, Ph.D.
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells
Noelle Williams, Ph.D.
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders
Yonghao Yu, Ph.D.
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation, and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modifications, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.
These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.
Diana Tomchick, Ph.D.
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques