Biological Chemistry Faculty

David Corey, Ph.D.

Benjamin Tu, Ph.D., Chair
Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast


Richard Bruick, Ph.D.
Bruick Lab
Research Interests: Regulation of the mammalian hypoxic response pathway


Igor Butovich, Ph.D.
Associate Professor
Butovich Lab
Research Interests: Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade


Chuo Chen, Ph.D.
Chen Lab
Research Interests: Natural product synthesis, synthetic methodology development, small molecule library synthesis and chemical biology


David Chuang, Ph.D.
Chuang Lab
Research Interests: Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding


Nicholas Conrad, Ph.D.
Associate Professor
Conrad Lab
Research Interests: Gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpes virus


David Corey, Ph.D.
Corey Lab
Research Interests: Engineering proteins and nucleic acids for novel function


Russell DeBose-Boyd, Ph.D.
DeBose-Boyd Lab
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism


Ivan D'Orso, Ph.D.
Assistant Professor
D'Orso Lab
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV


George DeMartino, Ph.D.
DeMartino Lab
Research Interests: Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases


J.R. Falck, Ph.D.
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry

Jinming Gao, Ph.D.

Jinming Gao, Ph.D.
Research Interests: Probing lysosome catabolism by nanoparticles; theranostic nanomedicine for cancer-targeted drug delivery; tumor-activatable imaging nanoprobes


Marie-Alda Gilles-Gonzalez, Ph.D.
Associate Professor
Research Interests: Mechanisms of O2, CO, and NO sensing and in novel signal-transduction heme proteins


John Hulleman, Ph.D.
Assistant Professor
Hulleman Lab
Research Interests: Protein misfolding diseases, stress-responsive signaling, chemical biology, high-throughput screening, drug discovery, age-related macular degeneration, retinal dystrophies


Jennifer Kohler, Ph.D.
Associate Professor
Kohler Lab
Research Interests: Understanding and exploiting the molecular foundations of glycoconjugate Biosynthesis


Mark Lehrman, Ph.D.
Lehrman Lab
Research Interests:
Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease


Wen-Hong Li, Ph.D.
Associate Professor
Li Lab
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multiphoton fluorescence microscopy; mechanisms and functions of cellular calcium signaling


Qinghua Liu Ph.D.
Associate Professor
Liu Lab
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease


Weibo Luo, Ph.D.
Assistant Professor
Luo Lab
Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis


John MacMillan, Ph.D.
Associate Professor
MacMillan Lab
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry


David McFadden, M.D., Ph.D.
Assistant Professor
McFadden Lab
Research Interests: Genetically engineered mouse models of cancer, chemical and genetic screens for new vulnerabilities in small cell lung cancer and Ewing sarcoma


Steven McKnight, Ph.D.
McKnight Lab
Research Interests: Molecular genetics and biochemical studies of mammalian gene regulation


Carole Mendelson, Ph.D.
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression


Peter Michaely, Ph.D.
Assistant Professor
Michaely Lab
Research Interests: Biochemical and structural study of receptor-mediated endocytosis and the membrane skeleton of the plasma membrane


Hamid Mirzaei, Ph.D.
Assistant Professor
Mirzaei Lab
Research Interests: Aging, drug discovery, neurodegeneration, proteomics


Yunsun Nam, Ph.D.
Assistant Professor
Nam Lab
Research Interests: Mechanisms of RNA-mediated gene regulation; Structural and biochemical studies of RNA function


Deepak Nijhawan, M.D., Ph.D.
Assistant Professor
Research Interests: Using chemistry to identify new cancer drug targets


Kim Orth, Ph.D.
Orth Lab
Research Interests: Signal transduction in the microbial pathogen Yersinia pestis


Steven Patrie, Ph.D.
Assistant Professor
Patrie Lab
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics


Margaret Phillips, Ph.D.
Phillips Lab
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites


Arun Radhakrishnan, Ph.D.
Assistant Professor
Radhakrishnan Lab
Research Interests: Protein-lipid interactions at membrane interfaces


Vanessa Sperandio, Ph.D.
Sperandio Lab
Research Interests: Quorum sensing in enteropathogenic Escherichia coli


Uttam Tambar, Ph.D.
Associate Professor
Tambar Lab
Research Interests: Synthesis of complex biologically active natural products; development of new tandem methodologies


Kosaku Uyeda, Ph.D.
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells


Kenneth Westover, M.D., Ph.D.
Assistant Professor
Westover Lab
Research Interests: Cancer biology and development of new therapeutic drugs


Noelle Williams, Ph.D.
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders


Jin Ye, Ph.D.
Associate Professor
Ye Lab
Research Interests: Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis


Qing Zhong, M.D., Ph.D.
Associate Professor
Zhong Lab
Research Interests: Biochemical mechanisms of mammalian autophagy; autophagy regulated primary ciliogenesis; and programmed cell death

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.


Anthony Michael, Ph.D.
Associate Professor
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes


Diana Tomchick, Ph.D.
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques


Yonghao Yu, Ph.D.
Assistant Professor
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation, and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modifications, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.