Biological Chemistry Faculty
Benjamin Tu, Ph.D.
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast
Jef De Brabander, Ph.D.
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode of action, using molecular pharmacology and biochemistry
Ivan D'Orso, Ph.D.
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV
Marie-Alda Gilles-Gonzalez, Ph.D.
Research Interests: Mechanisms of O2, CO and NO sensing and in novel signal-transduction heme proteins
Bethany Janowski, Ph.D.
Research Interests: Gene regulation by small RNAs
Mark Lehrman, Ph.D.
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease
Wen-Hong Li, Ph.D.
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multi-photon fluorescence microscopy; mechanisms and functions of cellular calcium signaling
Qinghua Liu, Ph.D.
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease
John MacMillan, Ph.D.
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry
Anthony Michael, Ph.D.
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes
Deepak Nijhawan, M.D., Ph.D.
Research Interests: Using chemistry to identify new cancer drug targets
Steven Patrie, Ph.D.
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics
Margaret Phillips, Ph.D.
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites
Arun Radhakrishnan, Ph.D.
Research Interests: Protein-lipid interactions at membrane interfaces
Diana Tomchick, Ph.D.
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques
Gomika Udugamasooriya, Ph.D.
Research Interests: Development of high affinity and specific peptidomimetics (e.g., peptoids); targeting specific cell surface receptors at a genome-wide approach for early detection and treatment of cancer
Kosaku Uyeda, Ph.D.
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells
Noelle Williams, Ph.D.
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders
Yonghao Yu, Ph.D.
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modiciations, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.