Biological Chemistry Faculty

David Corey, Ph.D.

Benjamin Tu, Ph.D., Chair
Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast

 

Richard Bruick, Ph.D.
Professor
Bruick Lab
Research Interests: Regulation of the mammalian hypoxic response pathway

 

Igor Butovich, Ph.D.
Associate Professor
Butovich Lab
Research Interests: Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade

 

Chuo Chen, Ph.D.
Professor
Chen Lab
Research Interests: Natural product synthesis, synthetic methodology development, small molecule library synthesis and chemical biology

 

David Chuang, Ph.D.
Professor
Chuang Lab
Research Interests: Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding

 

Nicholas Conrad, Ph.D.
Associate Professor
Conrad Lab
Research Interests: Gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpes virus

 

David Corey, Ph.D.
Professor
Corey Lab
Research Interests: Engineering proteins and nucleic acids for novel function

 

Russell DeBose-Boyd, Ph.D.
Professor
DeBose-Boyd Lab
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism

 

Ivan D'Orso, Ph.D.
Assistant Professor
D'Orso Lab
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV

 

George DeMartino, Ph.D.
Professor
DeMartino Lab
Research Interests: Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases

 

J.R. Falck, Ph.D.
Professor
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry

 
Jinming Gao, Ph.D.

Jinming Gao, Ph.D.
Professor
Research Interests: Probing lysosome catabolism by nanoparticles; theranostic nanomedicine for cancer-targeted drug delivery; tumor-activatable imaging nanoprobes

 

Marie-Alda Gilles-Gonzalez, Ph.D.
Associate Professor
Research Interests: Mechanisms of O2, CO, and NO sensing and in novel signal-transduction heme proteins

 

John Hulleman, Ph.D.
Assistant Professor
Hulleman Lab
Research Interests: Protein misfolding diseases, stress-responsive signaling, chemical biology, high-throughput screening, drug discovery, age-related macular degeneration, retinal dystrophies

 

Jennifer Kohler, Ph.D.
Associate Professor
Kohler Lab
Research Interests: Understanding and exploiting the molecular foundations of glycoconjugate Biosynthesis

 

Mark Lehrman, Ph.D.
Professor
Lehrman Lab
Research Interests:
Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease

 

Wen-Hong Li, Ph.D.
Associate Professor
Li Lab
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multiphoton fluorescence microscopy; mechanisms and functions of cellular calcium signaling

 

Qinghua Liu Ph.D.
Associate Professor
Liu Lab
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease

 

Weibo Luo, Ph.D.
Assistant Professor
Luo Lab
Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis

 

John MacMillan, Ph.D.
Associate Professor
MacMillan Lab
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry

 

David McFadden, M.D., Ph.D.
Assistant Professor
McFadden Lab
Research Interests: Genetically engineered mouse models of cancer, chemical and genetic screens for new vulnerabilities in small cell lung cancer and Ewing sarcoma

 

Steven McKnight, Ph.D.
Professor
McKnight Lab
Research Interests: Molecular genetics and biochemical studies of mammalian gene regulation

 

Carole Mendelson, Ph.D.
Professor
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression

 

Peter Michaely, Ph.D.
Assistant Professor
Michaely Lab
Research Interests: Biochemical and structural study of receptor-mediated endocytosis and the membrane skeleton of the plasma membrane

 

Hamid Mirzaei, Ph.D.
Assistant Professor
Mirzaei Lab
Research Interests: Aging, drug discovery, neurodegeneration, proteomics

 

Yunsun Nam, Ph.D.
Assistant Professor
Nam Lab
Research Interests: Mechanisms of RNA-mediated gene regulation; Structural and biochemical studies of RNA function

 

Deepak Nijhawan, M.D., Ph.D.
Assistant Professor
Research Interests: Using chemistry to identify new cancer drug targets

 

Kim Orth, Ph.D.
Profesor
Orth Lab
Research Interests: Signal transduction in the microbial pathogen Yersinia pestis

 

Steven Patrie, Ph.D.
Assistant Professor
Patrie Lab
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics

 

Margaret Phillips, Ph.D.
Professor
Phillips Lab
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites

 

Arun Radhakrishnan, Ph.D.
Assistant Professor
Radhakrishnan Lab
Research Interests: Protein-lipid interactions at membrane interfaces

 

Vanessa Sperandio, Ph.D.
Professor
Sperandio Lab
Research Interests: Quorum sensing in enteropathogenic Escherichia coli

 

Uttam Tambar, Ph.D.
Associate Professor
Tambar Lab
Research Interests: Synthesis of complex biologically active natural products; development of new tandem methodologies

 

Kosaku Uyeda, Ph.D.
Professor
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells

 

Kenneth Westover, M.D., Ph.D.
Assistant Professor
Westover Lab
Research Interests: Cancer biology and development of new therapeutic drugs

 

Noelle Williams, Ph.D.
Professor
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders

 

Jin Ye, Ph.D.
Associate Professor
Ye Lab
Research Interests: Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis

 

Qing Zhong, M.D., Ph.D.
Associate Professor
Zhong Lab
Research Interests: Biochemical mechanisms of mammalian autophagy; autophagy regulated primary ciliogenesis; and programmed cell death

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

 

Anthony Michael, Ph.D.
Associate Professor
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes

 

Diana Tomchick, Ph.D.
Professor
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques

 

Yonghao Yu, Ph.D.
Assistant Professor
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation, and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modifications, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.