Biological Chemistry Faculty

Benjamin Tu, Ph.D.
Chair
Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast


Richard Bruick, Ph.D.
Associate Professor
Bruick Lab
Research Interests: Regulation of the mammalian hypoxic response pathway


Igor Butovich, Ph.D.
Associate Professor
Butovich Lab
Research Interests: Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade


Chuo Chen, Ph.D.
Associate Professor
Chen Lab
Research Interests: Natural product synthesis, synthetic methodology development, small molecule library synthesis and chemical biology


David Chuang, Ph.D.
Professor
Chuang Lab
Research Interests: Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding


Nicholas Conrad, Ph.D.
Assistant Professor
Conrad Lab
Research Interests: Gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpes virus


David Corey, Ph.D.
Professor
Corey Lab
Research Interests: Engineering proteins and nucleic acids for novel function


Russell DeBose-Boyd, Ph.D.
Professor
DeBose-Boyd Lab
Research Interests: Regulation of HMG-CoA reductase and sterol metabolism


Jef De Brabander, Ph.D.
Professor
De Brabander Lab
Research Interests: Synthesis of natural products and other molecular architectures and interrogation of their mode of action, using molecular pharmacology and biochemistry


Ivan D'Orso, Ph.D.
Assistant Professor
D'Orso Lab
Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV


George DeMartino, Ph.D.
Professor
DeMartino Lab
Research Interests: Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases


J.R. Falck, Ph.D.
Professor
Falck Lab
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry


Kevin H. Gardner, Ph.D.
Professor
Gardner Lab
Research Interests: Biophysical and biochemical studies of photosensors and other environmental sensors


Marie-Alda Gilles-Gonzalez, Ph.D.
Associate Professor
Research Interests: Mechanisms of O2, CO and NO sensing and in novel signal-transduction heme proteins


Bethany Janowski, Ph.D.
Associate Professor
Research Interests: Gene regulation by small RNAs


Jennifer Kohler, Ph.D.
Assistant Professor
Kohler Lab
Research Interests: Understanding and exploiting the molecular foundations of glycoconjugate biosynthesis


László Kürti, Ph.D.
Assistant Professor
Kürti Lab
Research Interests: Enantioselective assembly of highly functionalized heterocycles and carbocycles


Mark Lehrman, Ph.D.
Professor
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease


Wen-Hong Li, Ph.D.
Associate Professor
Li Lab
Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multi-photon fluorescence microscopy; mechanisms and functions of cellular calcium signaling


Qinghua Liu, Ph.D.
Associate Professor
Liu Lab
Research Interests: Cellular use of small RNAs to specifically silence gene expression; harnessing RNAi to shut down expression of pathological genes to cure human disease


John MacMillan, Ph.D.
Associate Professor
MacMillan Lab
Research Interests: Isolation and structural determination of biologically active natural products from marine bacteria; new methodology for stereochemical assignment; medicinal chemistry


Steven McKnight, Ph.D.
Professor
McKnight Lab
Research Interests: Molecular genetics and biochemical studies of mammalian gene regulation


Carole Mendelson, Ph.D.
Professor
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression


Anthony Michael, Ph.D.
Associate Professor
Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes


Peter Michaely, Ph.D.
Assistant Professor
Michaely Lab
Research Interests: Biochemical and structural study of receptor-mediated endocytosis and the membrane skeleton of the plasma membrane


Hamid Mirzaei, Ph.D.
Assistant Professor
Mirzaei Lab 


Deepak Nijhawan, M.D., Ph.D.
Assistant Professor
Research Interests: Using chemistry to identify new cancer drug targets


Kim Orth, Ph.D.
Profesor
Orth Lab
Research Interests: Signal transduction in the microbial pathogen Yersinia pestis


Steven Patrie, Ph.D.
Assistant Professor
Patrie Lab
Research Interests: Proteomics; mass spectrometry and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders; cancer epigenetics


Margaret Phillips, Ph.D.
Professor
Phillips Lab
Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites


Arun Radhakrishnan, Ph.D.
Assistant Professor
Research Interests: Protein-lipid interactions at membrane interfaces


Joseph Ready, Ph.D.
Professor
Ready Lab
Research Interests: Discovery and application of new chemical reactions; total synthesis of complex molecules


Daniel Siegwart, Ph.D.
Assistant Professor
Siegwart Lab
Research Interests: Polymer and materials chemistry, drug and gene delivery, RNAi, biomedical imaging, detection and treatment of cancer


Vanessa Sperandio, Ph.D.
Professor
Sperandio Lab
Research Interests: Quorum sensing in enteropathogenic Escherichia coli


Uttam Tambar, Ph.D.
Assistant Professor
Tambar Lab
Research Interests: Synthesis of complex biologically active natural products; development of new tandem methodologies


Diana Tomchick, Ph.D.
Professor
Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques


Gomika Udugamasooriya, Ph.D.
Assistant Professor
Udugamasooriya Lab
Research Interests: Development of high affinity and specific peptidomimetics (e.g., peptoids); targeting specific cell surface receptors at a genome-wide approach for early detection and treatment of cancer


Kosaku Uyeda, Ph.D.
Professor
Research Interests: Elucidation of biochemical mechanisms for regulation of carbohydrate metabolism in mammalian cells


Kenneth Westover, M.D., Ph.D.
Assistant Professor
Westover Lab
Research Interests: Cancer biology and development of new therapeutic drugs


Noelle Williams, Ph.D.
Associate Professor
Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders


Jin Ye, Ph.D.
Associate Professor
Ye Lab
Research Interests: Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis


Yonghao Yu, Ph.D.
Assistant Professor
Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modiciations, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.