Research Highlights

Inaccurate respiratory rates could impact patient safety, researchers say

Inaccurate respiratory rates could impact patient safety, researchers say

 

Patients’ respiratory rates are often not accurately recorded in the hospital, researchers in UT Southwestern Medical Center’s Center for Patient-Centered Outcomes Research have found.

Researchers report chemical reaction with potential to speed drug development

Researchers report chemical reaction with potential to speed drug development

 

Chemists have long sought to develop new reactions for the direct conversion of simple hydrocarbon building blocks into valuable materials such as pharmaceuticals in a way that dependably creates the same chemical bonds and orientations. UT Southwestern researchers have hit upon a novel way to do that.

Possible early diagnosis of autism spectrum disorder

Possible early diagnosis of autism spectrum disorder

 

Measuring a set of proteins in the blood may enable earlier diagnosis of autism spectrum disorder (ASD), according to a study from the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center.

Maternal lipid receptor linked to bone health in offspring

Maternal lipid receptor linked to bone health in offspring

 

UT Southwestern Medical Center researchers have found that a metabolic abnormality affects the quality of breast milk, leading to improper bone development in offspring.

Researchers identify feedback loop that regulates essential metabolite

Researchers identify feedback loop that regulates essential metabolite

 

UT Southwestern Medical Center researchers have identified a feedback loop that precisely maintains levels of a metabolite essential for many cellular processes. Their basic science findings could have implications for many diseases, including cancer.

Finding a metabolic function for marks on the proteins that package our DNA

Finding a metabolic function for marks on the proteins that package our DNA

 

UTSW researchers have determined that cellular modifications of histones, a class of proteins that package our DNA, serve an unexpected metabolic function.

Mutations in telomerase promoter counteract loss-of-function mutations

Mutations in telomerase promoter counteract loss-of-function mutations

 

A study by UT Southwestern Medical Center scientists describes noncoding mutations in regulatory DNA sequences that protect against the adverse effects of pulmonary fibrosis, a lung disease.

Researchers solve structure of protein linked to developmental problems

Researchers solve structure of protein linked to developmental problems

 

UT Southwestern researchers have solved the crystal structure of the yeast version of a protein that is crucial for human development.

Scientists find that it pays to count RNA

Scientists find that it pays to count RNA

 

UT Southwestern Medical Center researchers have found that a small number of mutated RNA molecules can have major consequences on neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

How visceral fat leads to excess glucose production

How visceral fat leads to excess glucose production

 

Researchers at UT Southwestern Medical Center have demonstrated a pathway by which abdominal fat, in particular fat surrounding the internal organs, may lead to type 2 diabetes.