Research Highlights

Maternal lipid receptor linked to bone health in offspring

Maternal lipid receptor linked to bone health in offspring

 

UT Southwestern Medical Center researchers have found that a metabolic abnormality affects the quality of breast milk, leading to improper bone development in offspring.

Researchers identify feedback loop that regulates essential metabolite

Researchers identify feedback loop that regulates essential metabolite

 

UT Southwestern Medical Center researchers have identified a feedback loop that precisely maintains levels of a metabolite essential for many cellular processes. Their basic science findings could have implications for many diseases, including cancer.

Finding a metabolic function for marks on the proteins that package our DNA

Finding a metabolic function for marks on the proteins that package our DNA

 

UTSW researchers have determined that cellular modifications of histones, a class of proteins that package our DNA, serve an unexpected metabolic function.

Mutations in telomerase promoter counteract loss-of-function mutations

Mutations in telomerase promoter counteract loss-of-function mutations

 

A study by UT Southwestern Medical Center scientists describes noncoding mutations in regulatory DNA sequences that protect against the adverse effects of pulmonary fibrosis, a lung disease.

Researchers solve structure of protein linked to developmental problems

Researchers solve structure of protein linked to developmental problems

 

UT Southwestern researchers have solved the crystal structure of the yeast version of a protein that is crucial for human development.

Scientists find that it pays to count RNA

Scientists find that it pays to count RNA

 

UT Southwestern Medical Center researchers have found that a small number of mutated RNA molecules can have major consequences on neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

How visceral fat leads to excess glucose production

How visceral fat leads to excess glucose production

 

Researchers at UT Southwestern Medical Center have demonstrated a pathway by which abdominal fat, in particular fat surrounding the internal organs, may lead to type 2 diabetes.

Joachim Herz Lab: Alzheimer’s risk

Joachim Herz Lab: Alzheimer’s risk

 

Researchers at the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center have compiled a review outlining how a specific form of protein increases the risk of developing Alzheimer’s disease.

Ege Kavalali Lab: Neural messaging

Ege Kavalali Lab: Neural messaging

 

A molecule that helps neurons communicate also controls how quickly brain cells reform neurotransmitter-storing packets needed to continue messaging with other cells, according to a new study from researchers at the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center.

Advance in synthetic chemistry should aid drug development

Advance in synthetic chemistry should aid drug development

 

Researchers at UT Southwestern Medical Center and collaborators report a significant advance in the synthesis of nitrogen-containing chemical compounds, which represent a majority of chemicals.