Research Grants — October 2009

Federal Grants 

Abrams, J., NIH, Molecular and Genetic Control of Programmed Cell Death, $225,000; Abrams, J., NIH, Genetics Training Program, $83,988, Alto, N., NIH, Type III Effector Regulation of Host GTPase Signaling, $250,000; Amatruda, J., NIH, Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebra Fish, $207,500; Barton, T., HRSA, Ryan White Title IV Program, $1,293,395.

octgrants

Bezprozvanny, I., NIH, Presenilins and Neuronal Calcium Signaling, $250,000 (supplement); Bezprozvanny, I., NIH, Structure/Function of Inositol Trisphosphate Receptor, $109,633 (supplement); Bezprozvanny, I., NIH, Deranged Calcium Signaling and Polyglutamine Expansion Disorders, $50,000 (supplement); Bezprozvanny, I., NIH, Deranged Calcium Signaling and Polyglutamine Expansion Disorders, $21,875; Bibb, J., NIH, The Role of Cdk5 in Addiction, $266,328.

Blount, P., NIH, High Throughput Screening: Bacterial Mechanosensitive Channels as Drug Targets, $50,000; Buszczak, M., NIH, Decoding Stem Cell Chromatin Using Drosophila, $190,000; Byerly, M., NIH/Duke Univ., A Comparision of Long-Acting Injectable Medications for Schizophrenia-ACLAIMS, $51,426; Castrillon, D., NIH, LKB1 Tumor Suppressor and Human Cancer, $706,985; Castrillon, D., NIH, Mentoring and Research in Mouse Models of Cancer and Infertility, $113,945.

Chen, D., NASA, Mechanisms of the Repair of HZE-Induced DNA Double-Strand Breaks in Human Cells, $47,770; Cobb, M., NIH, Insulin-Regulated MAP Kinase Pathways, $56,000 (supplement); Cohen, J., NIH, Genetic Susceptibility to Adverse Metabolic Consequences of Obesity, $475,000; Cowan, C., NIH, Signaling Mechanisms of Retinal Axon Guidance, $225,000; Crandall, C., NIH, Neural and Non-Neural Modulators of Skin Blood Flow and Sweating in Humans, $301,894.

DeMartino, G., NIH, Function and Regulation of the Proteasome, $205,000; Falck, J., NIH, Novel Eicosanolds: Synthesis and Function, $302,000; Falck, J., NIH/Med. Coll. of Wis., Microvessel O2 Responses in Salt-Sensitive Hypertension, $12,679; Fu, Q., NIH, Hypertension and Antihypertensive Therapy in Elderly Women, $378,528; Gao, J., NIH, MFe204-Loaded Polymer Micelles as Ultrasensitive MR Molecular Proves, $71,779 (supplement).

Gao, J., NIH, Ultrasensitive MR Proves for Molecular Diagnosis of Lung Cancer, $207,500; Garcia, C., NIH, Pulmonary Fibrosis and Telomerase Dysfunction, $145,585 (supplement); Garcia, C., NIH, Pulmonary Fibrosis and Telomerase Dysfunction, $10,000 (supplement); Garcia, C., NIH, The Molecular Basis of Familial Spontaneous Pneumothoraz, $140,000, Gardner, K., NIH, Structural Studies of PAS Domain Signaling Mechanisms, $193,670.

Gerard, R., NIH, Targeted Imaging Using Adenoviral Vectors, $171,000; Ghose, S., NIH, A Gene Environment Interaction in Schizophrenia, $155,300; Gibson, J., NIH, Cortical Circuit Changes and Mechanisms in a Mouse Model of Fragile X Syndrome, $186,750; Goldsmith, E., NIH, Interactions and Dual Phosphorylation in MAP Kinase Cascades, $180,316; Goldstein, J., NIH, Molecular Basis of Cholesterol Metabolism, $248,868 (supplement).

Halm, E., NIH, Long-Term Outcomes of Carotid Endarterectomy in the Elderly, $67,200 (supplement); Hamra, F., NIH, Discovery and Function of Fertilization-Specific Molecules, $188,167; Henkemeyer, M., NIH, Eph-Ephrin Bidirectional Signaling in Visual Development, $242,750; Hilgemann, D., NIH, Cardiac Function and PIP2, $250,000; Hiesinger, P., NIH, Regulation of Synaptic Specificity in the Visual System by Intracellular Traffic, $250,000.

Hofmann, S., NIH, Molecular Basis of Infantile NCL, $50,000 (supplement); Hoopman, T., NIH, Gene Expression by Moraxella Catarrhalis in VIVO, $100,000; Horton, J., NIH, Task Force for Obesity Research at Southwestern, $245,250; Hsieh, J., NIH, Epigenetic Regulation of Adult Neurogenesis, $205,000; Huang, L., NIH, Erythropoietin Receptor Signaling in Erythropoiesis, $157,280 (supplement).

Huang, L., NIH, Erythropoietin Receptor Signaling in Erythropoiesis, $250,000; Huber, K., NIH, Mechanisms of mGluR-Dependent Synaptic Plasticity, $200,000; Huber, K., NIH, Study of Fragile X Mental Retardation Protein in Synaptic Function and Plasticity, $252,260; Husain, M., NIH, 6/8- Prolonging Remission in Depressed Elderly, $149,863; Inrig, J., NIH, Blood Pressure, Endothelial Cell Dysfunction and Outcomes in Dialysis Patients, $120,735.

Jacobe, H., NIH, Assessment in Morphea for the Establishment of Non-Cutaneous Disease, $102,250; Jiang, Q., NIH, Obtaining 3-D Structures With Subnanogram Macromolecules, $165,000; Johnson, J., NIH, bHLH Transcription Factors in Neural Development, $209,074; Kedzierski, W., NIH, Elovl4 in Retinal Physiology and Pathophysiology, $200,000; Kernie, S., NIH, The Role of Neural Stem Cells in Traumatic Brain Injury, $8,693 (supplement).

Kohler, J., NSF, CAREER: a Genetic Method to Study Interactions Among Extracellular Proteins, $112,483; Kramer, H., NIH, Genetics of Endocytic Trafficking in the Eye, $10,000 (supplement); Leveno, K., NIH, NICHD Maternal Fetal Medicine Units Network, $1,851,011; Li, W., NIH, Photo-Activatable Fluorophores and Techniques for Biological Imaging Applications, $174,780; Lin, W., NIH, Patterning and Formation of the Neuromusclar Junction, $115,864 (supplement).

Liu, Q., NIH, Molecular Mechanism of Small RNA-Induced RNA Silencing, $184,489; Liu, Z., NIH, Role of FOXO4 in Atherosclerosis, $218,475; Lu, Q. R., NIH, Olig2 in Oligodendrocyte Myelination and Remyelination, $11,200 (supplement); Lum, L., NIH, Hedgehog Signal Transduction Across the Cell Membrane, $18,692; MacDonald, R., NIH, Transcriptional Regulators of Exocrine Pancreatic Development, $99,416 (supplement).

Malloy, C., NIH, Skeletal Mitochondrial Function, Body Weight, and Diabetes, Project 5 of 10, $245,250; McClung, C., NIH, Circadian Regulation of Dopaminergic Activity and Restless Legs Syndrome, $10,938, McClung, C., NIH, Addiction-Like Behavior in Models of Mood Disorders: Role of CLOCK and NPAS2, $250,000; McCracken, G., NIH, Pediatric Pharmacology Research Unit, $104,680 (supplement); Mendelson, C., NIH, Cellular Mechanisms in the Induction of Aromatase, $204,428.

Meredith, D., NIH, Regulation of Ptf1a in the Developing Nervous System, $27,876; Michaely, P., NIH, Characterization of the Role of ARH on LDLR Function, $127,280 (supplement); Michaely, P., NIH, Characterization of the Role of ARH on LDLR Function, $145,650; Niederkorn, J., NIH, Immunobiology of Corneal Allografts, $265,996; Niederkorn, J., NIH, Transplant and Tumor Rejection Processes Within the Eye, $290,996.

Olsen, N., NIH/ArthroChip, Gene Expression and Diagnosis of Autoimmune Disease, $127,389; Orth, K., NIH, Biochemical Characterization of Yersinia Effector YopJ, $20,000; Parada, L., NIH, NF Center: From Animal Models to Therapeutics, $1,086,352; Parks, E., NIH, Effect of Dietary Macronutrient Composition and Weight Loss on Liver Substrate Me, $283,949; Partch,C., NIH, Molecular Basis of Selectivity for Coactivator Recruitment of ARNT PAS Domains, $51,710.

Pertsemlidis, A., NIH, MicroRNA Regulation of Drug Sensitivity in Non-Small-Cell Lung Cancer, $171,000; Phelan, H., U.S. Army, DOD/UTHSC Houston, Prospective Observational Multicenter Massive Transfusion Study, $311,909; Punaro, M., Hackensack Univ. Med. Ctr./Arthritis Fndtn., Development of Ultrasound and Clinical Disease Measures for Localized Scleroderma, $2,500; Raskin, P., NIH/Univ. of South Fla., Diabetes TrialNet Data Coordinating Center, $107,188: Raskin, P., NIH/Univ. of South Fla., Diabetes TrialNet Data Coordinating Center, $71,342.

Repa, J., NIH, TorS – Interdisciplinary Research Training Program, Project 8 of 10 RL9, $128,053; Repa, J., NIH, TorS – Interdisciplinary Research Training Program, Project 8 of 10 TL1, $107,796; Rosenfeld, C., NIH, Studies of Uteroplacental Circulation, $207,500; Russell, D., NIH, Mouse Phenotype Core, Project 9 to 10, $235,702; Savani, R., NIH, ABCA3 and the Response to Lung Injury, $85,104 (supplement).

Scaglioni, P., NIH, Post-Transcriptional Regulation of PML Function, $123,975; Scherer, P., DOD, A New Candidate Breast Cancer Marker Linked to Resistance to Platinum Based Cancer Drugs, $75,000; Schiller, J., NIH, Physician Scientist Oncology Training Program, $112,620; Skinner, C., NIH, Facilitating Risk-Appropriate Colorectal Cancer Testing, $258,955; Smith, C., NIH, Analysis of PDFR Alpha Signaling in Cardiac Fibroblast Development and Function, $27,996.

Souza, R., NIH, Role of Acid in the Development of Barrett’s Esophagus, $196,500; Souza, R., NIH, Role of Acid in the Development of Barrett’s Esophagus, $171,500; Tamminga, C., NIH, Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotypes, $562,616; Terada, L., NIH, Effect of HIV Tat on Endothelial Cell Function, $225,000; Terman, J., NIH, Molecular Mechanisms of Axon Guidance and Neural Connectivity, $225,000.

Thorpe, P., NIH, Broad Spectrum Treatment of Hemmorrhagic Arenaviruses, $244,533; Trivedi, M., NIH, Using Information Technology to Provide Measurement-Based Care for Chronic Illness, $301,718; Turcott, M., NSF, A Computational Survey of Excitable Competence Circuits in Bacillus Subtilis, $102,788; vanOers, N., NIH, PTPN4 Functions in Lymphocytes, $125,000; vanOers, N., NIH, Integrative Immunology Training Program, $335,013.

Wiebe, D., NIH, Parental Involvement in Diabetes Care Across Adolescence, $450,513; Womack, K., NIH, Radiological Biomarkers for Frontotemporal Lobar Degeneration, $97,860; Wright, W., NIH, Gene Expression in Aging and Development, $259,126; Wu, L., NIH, Image-Based Phenotypic Profiling of Single-Cell Responses to Perturbations, $221,444; Xiao, G., NSF, Collaborative Research: Bayesian Hierarchical Methods for Modeling Chromosomal Spatial Correlation, $17,403.

Yang, Y., NIH, PLAGL2 Expression in Emphysema Patient Lungs, $50,000; Yin, H., NIH, Phosphoinositide Regulation of the Golgi, $202,603; Yu, H., NIH, Protection of Centromeric Cohesion by Bub1 and Sgo1, $88,798 (supplement); Yuan, D., NIH, The Role of Activated NK Cells in a Mouse Model of Lupus Erythematosus, $214,324; Yuan, D., NIH, The Role of Activated NK Cells in a Mouse Model of Lupus Erythematosus, $23,814.
 
Nonfederal Grants

Altschuler, S., Welch Fndtn., Multidimensional Profiling of Chemical Perturbations to the Insulin-Signaling Pathway, $50,000; Auchus, R., Welch Fndtn., Hydrogen Atom Transfer Mechanisms in Steroid Hydroxylases, $50,000; Blount, P., Welch Fndtn., Determining Lipid-Protein Interactions for a Channel Gated by Membrane Tension, $50,000; Brown, K., Welch Fndtn., Design and Synthesis of Tumor-Targeted Drug Delivery Systems for Lung Cancer Therapy, $50,000; Bruick, R., Welch Fndtn., Cellular Iron Sensing and Regulation of Iron Regulatory Protein 2, $50,000.

Cannon, S., Musc. Dys. Assn., Mechanistic Studies on the Pathophysiology of Hypokalemic Periodic Paralysis (MDA 135815), $117,668; Cannon, S., Musc. Dys. Assn., A Mouse Model of Hypokalemic Periodic Paralysis Type 2, $86,364; Chen, C., Welch Fndtn., Synthesis of Lancifodilactone F. and Buxapentalactone, $50,000; Chen, Z., Welch Fndtn., Biochemical Mechanism of IKK Activation by TRAF Proteins, $80,000; Chook, Y., Welch Fndtn., The Structural Basis for Substrate Specificity Overlap in Yast Nuclear Import Pathways, $50,000.

Chuang, D., Welch Fndtn., Mitochondrial Signaling by Reversible Phosphorylation, $60,000; Cobb, M., Welch Fndtn., Regulatory and Catalytic Properties of MAP Kinase Cascades, $90,000; Corey, D., Welch Fndtn., Recognition of DNA by Synthetic Oligomers, $90,000; De Brabander, J., Welch Fndtn., Novel Heterocyclizations for Natural Product Synthesis, $70,000; Deisenhofer, J., Welch Fndtn., Structural Studies of DNA Photolyases and Cryptochromes, $90,000.

DeMartino, G., Welch Fndtn., Deubiquitylation by the 26S Proteasome, $50,000; Frohman, E., Brigham and Women’s Hosp., Partners Multiple Sclerosis Clinical Fellowship Program, $120,000 (Von Burton, E., fellow); Gardner, K., Welch Fndtn., Comparative Studies of the Signaling Mechanisms of Flavin-Based Protein Photosensors, $50,000; Garrard, W., Welch Fndtn., Formaldehyde Cross-Linking for Discovery of Novel Regulatory Elements Exhibiting Long-Range Interactions Within and Between Chromosomes, $50,000; Gilles-Gonzalez, M., Welch Fndtn., Enzymology of the DosT Oxygen Sensor or M. Tuberculosis, $50,000.

Goldsmith, E., Welch Fndtn., The Serpin Inhibitory Mechanism, $80,000; Grishin, N., Welch Fndtn., Structural Studies of Novel NMV Synthetase Encoded by nadE, $50,000; Hiesinger, R., Welch Fndtn., Biochemical Charactrization of a Synaptic Function of Palmitoleic Acid, the Product of a Novel Delta 9 Fatty Acid Desaturase, $50,000; Hoffman, S., Welch Fndtn., Regulation of Protein Palmitoylation by PDZ Domain-Mediated Interactions; $50,000; Hooper, L., Welch Fndtn., Biochemical Basis for Peptidoglycan Binding by a Bactericidal Lectin, $50,000.

Hsieh, J., Welch Fndtn., Chemical Regulation of Neural Progenitor/Cancer Stem Cells, $50,000; Jiang, Q., Welch Fndtn., Structural Basis for the Calcium Modulation of an Inositol 1,4,5-Trisphophate Receptor, $50,000; Jiang, Y., Welch Fndtn., Structural and Functional Studies of RCK-Regulated Potassium Channel, $50,000; Kelly, N., Amer. Acad. of Pediatrics, Resident Oral Health Initiative, $2,871 (Troendle, D., and Troendle, S., fellows); Kliewer, S., Welch Fndtn., Regulation of Lipid Metabolism and Insulin Sensitivity by Nuclear Fatty-Acid Receptors and Fibroblast Growth Factor 21, $80,000.

Kohler, J., Welch Fndtn., A Photo-Sugar for O-GicNAC Interaction Discovery, $50,000; Lehrman, M., Welch Fndtn., Endoplasmic Reticulum Stress-Dependent Hexose Phosphate Mobilization, $50,000; Li, W., Welch Fndtn., Small Molecules as Modulators of Cell-Cell Junctional Communication, $50,000; Liu, Q., Welch Fndtn., Mechanistic Studies of the Drosophila RNA Interference Pathway, $50,000; Liu, Y., Welch Fndtn., Biochemical Analysis of COP9 Signalosome: A Conserved Cullin Deneddylation Enzyme, $60,000.

Lum, L., Welch Fndtn., Modulation of Canonical Wnt Pathway Activity Using Small Molecules, $50,000; MacMillan, J., Welch Fndtn., New Methodology for the Determination of Absolute Stereochemistry of Polyketides, $50,000; Mangelsdorf, D., Welch Fndtn., Ligand Binding Properties of Nematode Orphan Nuclear Receptors, $80,000; Norgard, M., Welch Fndtn., Crystallographic Analysis of Treponema Pallidum Lipoproteins, $60,000; Olson, E., Donald W. Reynolds, MicroRNA Control of Heart Disease: From New Biology to New Therapeutics, $500,000.

Olson, E., Amer. Diabetes Assn., Decoding the Therapeutic Potential of MicroRNA and Its Target for Improving Cardiovascular Risk in Diabetes, $45,000 (Grueteu, C., fellow); Orth, K., Welch Fndtn., Biochemical Characterization of Yeast Pbs2 Kinase Mutants That Suppress the Inhibitory Activity of Yersinia Effector YopJ, $80,000; Parada, L., James S. McDonnell Foundation, Large-Scale Screening for Therapeutic Targets in a Mouse Model of Glioma, $90,000; Phillips, M., Welch Fndtn., Structural Basis for Substrate Specificity in the b/a-Barrel Fold Decarboxylases, $90,000; Ranganathan, R., Welch Fndtn., Evolutionary Design of Protein Structure and Function, $80,000.

Ready, J., Welch Fndtn., Synthesis and Application of Optically Active Allenes, $50,000; Rice, L., Welch Fndtn., Engineering Ab-Tubulin to Dissect the Molecular Mechanisms of Microtubule Assembly, $50,000; Rizo-Rey, J., Welch Fndtn., NMR Methods to Study Membrane Proteins in Lipid Bilayers, $60,000; Rosen, M., Welch Fndtn., Genetically Encoded Photoswitchable Proteins: Tools to Understand Cell Migration and Signaling, $50,000; Ross, E., Welch Fndtn., Phospholipase C-b as Gg GAP and Effector, $50,000.

Russell, D.,
Welch Fndtn., Mammalian Etherase Enzymes, $60,000; Scaglioni, P., Amer. Italian Cancer Fndtn., Identification of the Signaling Networks Regulating Oncogene-Induced Replicative Senescence in Non-Small-Cell Lung Cancer, $35,000 (Rabellino, A., fellow); Schwarz, M., Amer. Acad. of Pediatrics, The Role of Ephrin B2 Reverse Signaling in Lung Morphogenesis, $5,000 (Bennett, K., fellow); Sternweis, P., Welch Fndtn., Structure and Mechanism of Signaling Enzymes and Pathways, $50,000.

Süel, G.,
Welch Fndtn., Amplification of Stochastic Fluctuations in Biochemical Reactions as a Mechanism for Cellular Differentiation, $50,000; Tu, B., Welch Fndtn., Functional Roles of the Biological Gases Hydrogen Sulfide and Carbon Monoxide, $50,000; Wang, X., Welch Fndtn., Delineating the Biochemical Pathway Underlining Autophagic Cell Death, $80,000; White, M., Welch Fndtn., Analysis of the Functional Significance of Complex Protein/Protein Interactions, $80,000; Winkler, W., Welch Fndtn., Affinity-Based Purification of Riboswitch Ligands, $50,000.

Wu, L., Welch Fndtn., Using Multiple Chemical Fluorophors to Profile the Spatial and Temporal Organization of the Insulin Response Network, $50,000; Yin, H., Welch Fndtn., Regulation of Type II Phosphatidylinositol Kinase Alpha by Oxidative Stress, $50,000; Yu, G., Welch Fndtn., Chemical Mechanism of the Gamma-Secretase Complex, $50,000; Yu, H., Welch Fndtn., Biochemical and Structural Analysis of the Spindle Checkpoint, $50,000; Zhang, C., Welch Fndtn., New Chemical Approaches to Study Hematopoietic Stem Cells, $50,000.

Zhang, X., Welch Fndtn., Studies of Autoinhibition Mechanisms for the GAPase-Activating Protein Activity of Plexin B1, $50,000; Zhao, Y., Welch Fndtn., A Novel Method for Probing Protein Geranylgeranylation, $50,000; Zou, H., Welch Fndtn., A Novel Tubulin Acetylation Catalyzed by San Acetyltransferase, $50,000. 

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