Jeffrey Zigman, MD, PhD

Associate Professor
Internal Medicine, Psychiatry
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

jeffrey.zigman@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Zigman grew up in New Jersey and performed undergraduate studies at Cornell University. He obtained a dual MD-PhD degree from the University of Chicago, and remained in Chicago to complete an Internal Medicine residency. Dr. Zigman next moved to Beth Israel Deaconess Medical Center in Boston, where he completed a fellowship in Endocrinology, Diabetes and Metabolism. It was in Boston, while working under the mentorship of Drs. Joel Elmquist and Jeffrey Garber, where Dr. Zigman’s research and clinical interests in the hormone ghrelin and thyroid nodular disease, respectively, first arose. Dr. Zigman is currently an Associate Professor of Internal Medicine at the University of Texas Southwestern Medical Center at Dallas, where he is affiliated with the Division of Hypothalamic Research and the Division of Endocrinology & Metabolism. He holds a secondary appointment in the Dept. of Psychiatry and also is affiliated with the Integrative Biology Graduate Program. His clinic primarily focuses on the treatment of individuals with thyroid nodules and thyroid cancer. Dr. Zigman’s research is geared primarily toward the study of the peptide hormone ghrelin and its effects on eating behaviors and mood.

Education

FellowshipBeth Israel Deaconess Medical Center, Endocrinology & Metabolism (2003)
Internship/ResidencyUniversity of Chicago Hospitals, Internal Medicine (2000)
Medical SchoolUniversity of Chicago Pritzker School of Medicine (1997)

Research Interests

Gastric bypass-associated changes in CNS physiology
Gastric endoendocrine cell function
Ghrelin biosynthesis and ghrelin cell physiology
Ghrelin's role in mood/depression/anxiety/stress
Investigation of the ghrelin-responsive neurons required for the development of diet-induced obesity
The role of ghrelin in reward seeking behaviors, such as those responsible for food intake, and in other hedonic (pleasurable) properties of eating

Publications

Featured
Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells.

Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM, Molecular endocrinology (Baltimore, Md.), 2011 Sep; 25 (9):1600-11

Featured
Ghrelin mediates stress-induced food-reward behavior in mice.

Chuang JC, Perello M, Sakata I, Osborne-Lawrence S, Savitt JM, Lutter M, Zigman JM, The Journal of clinical investigation, 2011 Jul; 121 (7):2684-92

Featured
Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice.

Zhao TJ, Sakata I, Li RL, Liang G, Richardson JA, Brown MS, Goldstein JL, Zigman JM, Proceedings of the National Academy of Sciences of the United States of America, 2010 Sep; 107 (36):15868-73

Featured
Ghrelin increases the rewarding value of high-fat diet in an orexin-deprendent manner

Mario Perello, Ichiro Sakata, Shari Birnbaum, Jen-Chieh Chuang, Sherri Osborne-Lawrence,Sherry A. Rovinsky, Jakub Woloszyn, Masashi Yanagisawa, Michael Lutter, and Jeffrey M. Zigman , Biological Psychiatry , 2010; (67):880-886

Featured
Co-localization of ghrelin O-acyltransferase (GOAT) and ghrelin in gastric mucosal cells

Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM , AJP Endo Metab , 2009; (297):E134-E141

In search of an effective obesity treatment: A shot in the dark or a shot in the arm?

Zigman JM, Elmquist JK , PNAS , August 2006; (103):12961-12962

Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.

Gautron L, Sakata I, Udit S, Zigman JM, Wood JN, Elmquist JK, The Journal of comparative neurology, 2011 Oct; 519 (15):3085-101

Functional implications of limited leptin receptor and ghrelin receptor co-expression in the brain.

Perello M, Scott MM, Sakata I, Lee CE, Chuang JC, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM, The Journal of comparative neurology, 2011 Jun;

Characterization of Kiss1 neurons using transgenic mouse models.

Cravo RM, Margatho LO, Osborne-Lawrence S, Donato J, Atkin S, Bookout AL, Rovinsky S, Frazão R, Lee CE, Gautron L, Zigman JM, Elias CF, Neuroscience, 2011 Jan; 173:37-56

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.

Donato J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S, Coppari R, Zigman JM, Elmquist JK, Elias CF, The Journal of clinical investigation, 2011 Jan; 121 (1):355-68

Honors/Awards

MS2 Outstanding Teaching Award

The University of Texas Southwestern Medical Center (2011)

Class of 2013 Outstanding Teaching Award in Physiology

The University of Texas Southwestern Medical Center (2010)

UTSW Medical Center Disease Oriented Clinical Scholar

The University of Texas Southwestern Medical Center (2006)

Graduation Cum Laude and with distinction in all subjects; Phi Beta Kappa National Honor Society from Cornell University

Cornell University (1989)

National Institutes of Health Medical Scientist Training Program

The University of Chicago (1989)

Professional Associations/Affiliations

American Association of Clinical Endocrinologists

American Diabetes Association

American Thyroid Association

The Endocrine Society

The Obesity Society