Elizabeth Maher, MD, PhD

Associate Professor
Endowed Title: Theodore H. Strauss Professorship in Neuro-Oncology
Internal Medicine, Neurology and Neurotherapeutics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

elizabeth.maher@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipDana Farber Cancer Center/Brigham & Women's Hospital, Hematology and Oncology (1999)
Internship/ResidencyUniversity of Toronto Hospitals - IM Residency, Internal Medicine (1996)
Medical SchoolMcGill University (1993)
Graduate SchoolMcGill University (1989)

Research Interests

Development of improved imaging techniques for brain tumors
Primary and metastatic brain tumors
Role of altered metabolism in the progression of malignant gliomas.

Publications

Featured
2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas

Choi C, Ganji S, DeBerardinis R, Hatanpaa K, Rakheja D, Kovacs Z, Tang X-L, Mashimo T, Raisanen J, Marin-Valencia I, Pascual J, Madden C, Mickey B, Malloy C, Bachoo R, Maher E., Nature Medicine, 2012; (Published online 26 January 2012)

Featured
Measurement of glycine in the human brain in vivo by (1) H-MRS at 3 T: application in brain tumors.

Choi C, Ganji SK, Deberardinis RJ, Dimitrov IE, Pascual JM, Bachoo R, Mickey BE, Malloy CR, Maher EA, Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 2011 Mar; :609-18

Featured
Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7T.

Choi C, Dimitrov IE, Douglas D, Patel A, Kaiser LG, Amezcua CA, Maher EA, NMR in biomedicine, 2010 Nov; 23 (9):1044-52

Featured
Brain metastasis: opportunities in basic and translational research.

Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S, Cancer research, 2009 Aug; 69 (15):6015-20

Featured
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities

Maher E, Brennan C, Wen P, Durso L, Ligon K, Richardson A, Khatry D, Freng B, Sinha R, Louis D, Quackenbush J, Black P, Chin L, DePinho R. , Cancer Research , ; (In Press)

Molecular diversity of astrocytes with implications for neurological disorders.

Bachoo R, Kim R, Ligon K, Maher E, Brennan C, Billings N, Chan S, Li C, Rowitch D, Wong W, DePinho R. , Proceedings of the National Academy of Sciences of the United States of America , June 2004; (101(22)):8384-8389

T(2) measurement of J-coupled metabolites in the human brain at 3T.

Ganji SK, Banerjee A, Patel AM, Zhao YD, Dimitrov IE, Browning JD, Sherwood Brown E, Maher EA, Choi C, NMR in biomedicine, 2011 Aug;

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.

Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM, Clinical cancer research : an official journal of the American Association for Cancer Research, 2010 Jan; 16 (1):154-63

The landscape of somatic copy-number alteration across human cancers.

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M, Nature, 2010 Feb; 463 (7283):899-905

A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma.

Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD, Cancer research, 2006 Nov; 66 (22):10815-23

Professional Associations/Affiliations

Society for Neuro-Oncology

(2003)

American Society of Clinical Oncology

(2001)