Darren McGuire, MD

Associate Professor
Endowed Title: Dallas Heart Ball Chair for Research on Heart Disease in Women
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

darren.mcguire@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Summary Biosketch Darren K. McGuire, MD, MHSc Dr. McGuire received his undergraduate degree from Hendrix College in Conway, Arkansas and his medical degree in 1993 from the Johns Hopkins University School of Medicine, inducted into the AOA medical honor society. He completed internal medicine residency at the University of Texas Southwestern Medical Center at Dallas and cardiology fellowship at Duke University, where he also spent 2 research years at the Duke Clinical Research Institute (DCRI) working on a number of large-scale, international clinical trials and registries. He served as the DCRI Chief Fellow 1999-2000, and during his research years, obtained a Masters Degree in Health Sciences-Clinical Trials from the Duke University School of Medicine. Dr. McGuire joined the cardiology faculty at UT-Southwestern in August, 2001 where he is presently Associate Professor of Medicine, Associate of the Donald W. Reynolds Cardiovascular Clinical Research Center, and Director of the Parkland Hospital and Health System Outpatient Cardiology clinics. His main clinical and research interests are in the long-term prevention of and risk-modification for cardiovascular disease, especially among the population of patients with diabetes. He is actively involved in studying the effects of a number of therapeutic intervention strategies among patients with diabetes and cardiovascular disease. He is senior editor of Diabetes and Vascular Disease Research, associate editor of the American Heart Journal, a Fellow of the American Heart Association and the American College of Cardiology, prior Chair of the AHA Diabetes Committee, and a member of the FDA Cardiovascular and Renal Drugs Advisory Committee.

Education

FellowshipDuke University School of Medicine, Cardiology (2001)
FellowshipUT Southwestern Medical Center at Dallas, Cardiology (1997)
ResidencyUT Southwestern Medical Center at Dallas, Internal Medicine (1996)
InternshipUT Southwestern Medical Center at Dallas, Internal Medicine (1994)
Medical SchoolJohns Hopkins University School of Medicine (1993)

Research Interests

Cardiovascular Clinical Outcomes trials
Diabetes and Vascular Disease
Disparities in health care and outcomes by race and sex
Epidemiology of coronary heart disease risk and prevention

Publications

Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.

Banks K, Puttagunta D, Murphy S, Lo M, McGuire DK, de Lemos JA, Chang AY, Grundy SM, Khera A, JACC. Cardiovascular imaging, 2011 Jan; 4 (1):65-73

No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction.

Britton KA, Aggarwal V, Chen AY, Alexander KP, Amsterdam E, Fraulo E, Muntner P, Thomas L, McGuire DK, Wiviott SD, Roe MT, Schubart UK, Fox CS, American heart journal, 2011 Apr; 161 (4):657-663.e1

Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.

de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK, JAMA : the journal of the American Medical Association, 2010 Dec; 304 (22):2503-12

Evaluation of the Glycometabolic Effects of Ranolazine in Patients With and Without Diabetes Mellitus in the MERLIN-TIMI 36 Randomized Controlled Trial.

Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E , Circulation , 2009; (119):20032-20039

Association Between Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) and Risk for Atherosclerosis: the Dallas Heart Study

Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK. , Diabetes Care , 2009; (32):1218-1220

New Drugs for the Treatment of Diabetes: Thiazolidinediones and their Evolving Cardiovascular Implications

McGuire DK, Inzucchi SE , Circulation , 2008; (117):440-449

New Drugs for the Treatment of Diabetes: Incretin-based Therapy and Beyond

Inzucchi SE, McGuire DK. , Circulation , 2008; (117):574-584

Honors/Awards

Outstanding Research Mentor Award

UT Southwestern Internal Medicine Housestaff (2011)

Hendrix College Odyssey Award in Research

Career Achievement in Clinical Research (2009)

Outstanding Teacher Award

UT Southwestern Senior Medical Student Class (2008)

Outstanding Teacher Award

UT Southwestern Internal Medicine Housestaff (2006)

Outstanding Fellow in Clinical Research

Duke University Cardiology Fellowship Award (2001)

Alpha Omega Alpha Medical Honor Society

Johns Hopkins University School of Medicine (1993)

Professional Associations/Affiliations

American Diabetes Association

Fellow, American College of Cardiology

Fellow, American Heart Association

Fellow, National Lipid Association