Beverly Rothermel, PhD

Assistant Professor
Internal Medicine, Molecular Biology
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

beverly.rothermel@utsouthwestern.edu

Biography

Beverly Rothermel, PhD, Assistant Professor

 

EDUCATION/TRAINING

 Cornell University; Ithaca, NY, BS 1982 Biology/Biochemistry

Yale University, New Haven, CT, MS 1986 Biology

Yale University, New Haven, CT, MPhil 1987 Biology

Yale University, New Haven, CT, PhD 1991 Cellular & Development

 

RESEARCH AND PROFESSIONAL EXPERIENCE:

1981-1982 Research Assistant, Boyce Thompson Institute, Ithaca, NY

1982-1983 Research Assistant with L.E. Anderson, University of Illinois, Chicago, IL

1984 Research Assistant with R. L. Satter, University of Connecticut, Storrs, CT

1984 Graduate Researchwith N. Ornston, Yale University, New Haven, CT

1985-1990 Graduate Research with T. Nelson, Yale University, New Haven, CT

1991-1996 Postdoctoral training with Drs. R. Butow and P. Perlman, UT Southwestern

1996-2000 Postdoctoral training with Dr. R. Sanders Williams, UT Southwestern

2000-present Assistant Professor, Internal Medicine, UT Southwestern

 

PROFESSIONAL ACTIVITES

1996-1997 Freelance editor for Current Protocols (John Wiley and Sons, NY)

1993-present American Genetic Society

1983-present American Association for the Advancement of Science

 

HONORS AND AWARDS

National Merit Scholar NIH Individual National Research Service Award NIH Institutional Research Fellowship American Cancer Society Postdoctoral Fellowship

 

ONGOING RESEARCH SUPPORT

American Heart Association, Texas Affiliate (7/1/01-6/31/03) Beginning-grant-in-aid "The MCIP Gene Family, Endogenous Regulators of Calcineurin Activity in Cardiac Development and Disease" Role: PI $62,000/yr for 2 years

NIH RO1 (12/13/2002-11/30/2007) "Modulating calcineurin signaling pathways in muscle" Role: PI $225,000/yr for 5 years

Education

Graduate SchoolYale University, Biology (1991)
UndergraduateCornell University, Biology (1982)

Research Interests

circadian rhythms
intracellular signaling
molecular and developmental cardiology
nuclear-mitochondrial interactions
transcriptional regulation

Publications

Featured
Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.

Sachan N, Dey A, Rotter D, Grinsfelder B, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, Bibb A, Hill A, Rothermel BA , Circ Research , 2011; (108):437-445

Featured
Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy

Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ, Rothermel BA, Hill JA , Circulation , 2008; (117):3070-3078

Featured
The Down Syndrome Critical Region Protein RCAN1 Regulates LTP and Memory via Inhibition of Phosphatase Signaling

Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, Shelton JM, Richardson JA, Klann E, Rothermel BA , J Neurosci , 2007; (27):13161-13172

Featured
Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers

Oh M, Rybkin I, Copeland V, Czubryt MP, Shelton J, Richardson JA, Hill JA, de Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA , Mol Cell Biol , 2005; (25):6629-6638

Featured
Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

Rothermel BA, McKinsey TA, Vega RB, Nicol RL, Mammen P, Yang J, Antos CL, Shelton JM, Bassel-Duby R, Olson EN, Williams RS , Proc Natl Acad Sci USA , 2001; (98):3328-3333

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, Gillette TG, Hill JA , Proc Natl Acad Sci U S A , 2011; (108):4123-4128

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S , J Cell Sci , 2011; (124):2143-2152

The CCAAT/enhancer binding protein beta (C/EBPb) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4

Oh M, Dey A, Gerard RD, Hill JA, Rothermel BA. , J Biol Chem , 2010; (285):16623-31

Mitochondrial Fission and Autophagy in the Normal and Diseased Heart

Iglewski M, Hill JA, Lavandero S, Rothermel BA , Curr Hypertens Rep , 2010; (12):418-425

Regulator of calcineurin 1 (Rcan1) controls growth plasticity of adult pancreas

Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, Williams JA , Gastroenterology , 1010; (139):609-619

Honors/Awards

American Cancer Society Postdoctoral Fellowship

National merit Scholar

NIH Individual National research Service Award

NIH Institutional Research Fellowship

Professional Associations/Affiliations

American Association for the Advancement of Science

American Genetics Society

American Heart Association

Genetics Society of America

Society For Research in Biological Rhythms