CancerGene is a computer program for estimating the likelihood that a family carries a mutation in one of the cancer predisposition genes. The user enters family history information which is then analyzed using a variety of mathematical models. The software draws a pedigree and archives family history and mutation probability information to a relational database.

CancerGene provides a user friendly graphical interface for generating the input files required by the BayesMendel BRCAPRO and MMRpro and PancPro programs that run seamlessly in the background. A detailed knowledge of mathematical risk models and cancer genetics is required to make use of CancerGene.

CancerGene is available to health care professionals involved in cancer risk counseling.

Features in CancerGene 5

  • The BayesMendel models, BRCAPRO, MMRpro, and PancPro are run as a component of the R-based BayesMendel package. These models calculate the probability of mutation in BRCA1, BRCA2, MLH1, MSH2, MSH6, and a hypothetical pancreas cancer susceptibility gene. They also calculate the probability of developing breast, ovarian, colorectal, endometrial, and pancreas cancer.
  • Penetrance functions for BayesMendel models are updated regularly.
  • Mutation testing information can be entered for BRCA1, BRCA2, MLH1, and MSH2, and MSH6.
  • Information on Microsatellite Instability (MSI) testing can be captured for each individual.
  • Breast cancer biomarker information can be entered for each breast cancer. This information is incorporated into the BRCA gene mutation calculation.
  • All of the parameters used by the BayesMendel models can be set by the user.
  • Gail and Claus models are included.
  • Family history information entry is simplified using shortcut keys and a redesigned interface.
  • CaGene5 users can rerun all families stored in prior versions of the CaGene database with the click of a button.