In the Department of Psychiatry, basic research at the molecular and cellular levels focuses on the fundamental processes controlling neuronal function and their abnormalities in various neuropsychiatric disorders. Studies of signal transduction pathways, gene expressions, and genetic contributions to mental illness are among the major areas of investigation. The studies make prominent use of transgenic mouse models, viral mediated gene transfer, DNA array profiling, and protein biochemistry.
Other areas of focus include neural circuits and the neurobiological substrates of complex behavior. Defining features of this work include its integration with molecular and cellular investigations and the availability of sophisticated animal models of specific disorders. A major interest is detailed neural and behavioral phenotyping of genetic mutant mice.
Basic Research Faculty
Robert Greene, M.D., Ph.D.
Lisa Monteggia, Ph.D.