Research

The following are representative of various research activities occurring in the Division of Neonatal-Perinatal Medicine at UT Southwestern Medical Center.

Clinical Research

      • NIH Neonatal Network for Clinical Trials: The Division of Neonatal-Perinatal Medicine is an active participant in the Neonatal Network clinical studies.
      • Treatment of chorioamnionitis-exposed neonates: Several alternative diagnostic tests and therapies have been promoted for the neonate whose mother is diagnosed with chorioamnionitis.
      • Follow-up care for very low birth weight and high-risk infants, including neurodevelopment, chronic disease, and nutrition is part of our ongoing study of these babies. 
      • Neonatal resuscitation: Randomized trials (e.g., temperature control, oxygen delivery, resuscitation educational interventions), observational studies (ETCO2 guidance of CPR, effectiveness of epinephrine dosing), as well as other observational studies using the resuscitation database, which includes detailed information about all resuscitation team calls since 2003.
      • Hypoxic-ischemic encephalopathy: Mechanism of injury; assessment of new recognition tools such as the amplitude EEG; translational research utilizing a piglet model of asphyxia; optimizing neuro-protection offered by hypothermia; rewarming after hypothermia; cerebrovascular hemodynamic modulation of asphyxiated infants; neuroimaging; neurodevelopment.
      • Studies in the newborn nursery: Late preterm infants, hypoglycemia, transcutaneous bilirubin, pulse oximetry screening for congenital heart disease.
      • Observational studies using available databases: Several research studies and quality improvement projects use information from available databases, including: the neonatal resuscitation database (Parkland, see above), the neonatal intensive care unit (NICU) databases at Parkland or Children’s Medical Center (CMC), the NICHD Neonatal Research Network Databases (Generic Database, Follow-up Database, and Moderate Preterm Registry), the Vermont-Oxford Network (Parkland NICU) and the Child Health Neonatal Consortium Database (CMC NICU).
      • Early evidence suggesting potential risk of metabolic syndrome in infancy among very low birth weight infants: Evidence for abnormal weight-to-length ratio, increased adiposity, glomerular hyperfiltration and high blood pressure in very low birth weight infants followed at the low birth weight clinic.
      • Nutritional and growth studies: Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants: Randomized Clinical Trial comparing individualized versus optimized supplementation of human milk; Quality improvement in nutrient administration and linear growth assessment.
      • Weaning CPAP in preterm infants: Randomized study comparing two modes of weaning CPAP: from 5 cm vs. decreasing from 5 to 4 and 3 cm 

Laboratory Research

  • Maternal and fetal cardiovascular physiology and development
  • Animal models relating to neonatal resuscitation and gestational hypertension
  • Pathogenesis of bronchopulmonary dysplasia/chronic lung disease, and novel therapies
  • Molecular basis of vascular disease
  • Pulmonary endothelial function, nitric oxide, persistent pulmonary hypertension, and calcium metabolism
  • Hyaluronan (Hyaluronic acid) and its role in inflammation and endothelial function
  • Probiotics/Commensal organisms and their effects on immune mediatros in the developing gut