Current Studies

The Clinical Research Program oversees the many clinical studies underway within the Department of Orthopaedic Surgery as part of our commitment to excellence in musculoskeletal care and resident mentoring and development as future clinical investigators.

Here are some of the clinical research studies in the Department:

Brigham Au, M.D.

  • A Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fractures Modern Ring External Fixators vs. Internal Fixation (FIXIT Study)
  • ACA: The Effect of the Affordable Care Act on Orthopaedic Trauma Patients at a Level One Trauma Center
  • Analysis of the Effect of the Complications Incurred Following a Traumatic Injury on the Clinical Outcomes in Orthopaedic Trauma Surgical Patients
  • Femoral Fractures Treated with Operative Fixation: Retro Review of Patients with and without Diabetes Mellitus
  • Local Antibiotic Therapy to Reduce Infection after Operative Treatment of Fractures at High Risk Infection: A Multicenter Randomized Controlled Trail (VANCO) [FDA IND #119891]
  • Operative vs. Non-Operative Treatment of Humeral Shaft Fractures
  • The Post Sarmiento Era: Is it Time to Re-think Expectations of Functional Bracing for Humeral Shaft Fractures?
  • The Version of Femoral Neck Fracture as Predictor for Percutaneous Fixation Failure
  • Treatment of Femoral Fracture in Trauma Patients

Robert Dimeff, M.D.

  • Improving Functional Movement Screen (FMS) Scores in Athletes Through Corrective Exercises Standardized Across Multiple Sports

Kenneth Estrera, M.D.

  • A Novel Risk Stratification Technique Using Pre-Operative Radiographs in Total Knee Arthoplasty (TKA)
  • Clinical and Laboratory Examination in Native Septic Arthritis: Experience at A Level One Trauma Center
  • Hip and Knee Replacement in Modern-Day Airports and Security Scanners
  • Revisions of Total Hip Replacements (THR) Registry
  • Total Hip Arthroplasty & Femoral Stem Fixation after Acute Femoral Neck Fractures
  • Total Knee Arthropasty (TKA) Registry
  • Utility and Cost of Magnetic Resonance Imaging of the Knee in Older Patients: A Retrospective Cohort Study

Paula Hernandez, Ph.D.

  • Changes in Chondrocyte Morphology in Osteoarthritic cartilage (HtrA1)
  • Study of Osteonecrosis on Femoral Head

Mohammed Khaleel, M.D.

  • Sleep Disturbances in Patients with Operative Spine Pathology

Michael Khazzam, M.D.

  • Anterior Cruciate Ligament Tear: Timing of Surgery and Incidence of Associated Intra-Articular Injuries
  • Are Smartphone App Goniometers a Suitable Replacement for the Conventional Goniometer in Assessing Passive and Active Shoulder Range or Motion?
  • Cerebral Desaturation Events in Beach Chair and Lateral Decubitus Positions During Shoulder Arthroscopy
  • Conventus CAGE™ PH Post-Approval Observational Data Collection Study
  • IV vs. Topical TXA in Primary Reverse Total Shoulder Arthroplasty: A Prospective Randomized Trail
  • Liposomal Bupivicaine vs. Interscalene Nerve Block for Pain Control After Total Shoulder Arthroplasty: A Randomized Clinical Trail
  • MOON Shoulder Instability: Patients Undergoing Operative Treatment of the Shoulder Capsule or Labrum
  • P. Acnes in Shoulder Arthroplasty: Is it Isolated to the Skin?
  • Pyrocarbon IDE Study
  • Tornier Shoulder Outcomes Study
  • (Khazzam/Mulligan) Effectiveness of Corticosteriod vs. Ketarolac Shoulder Injections: a Prospective Double-Blinded Randomized Trail (Ketorolac)
  • (Khazzam/Mulligan) Shoulder Sleep Registry
  • (Khazam/Phelan) Subscapularis Integrity and Function Following Anatomic and Reverse Total Shoulder Arthroplasty

Trapper Lalli, M.D.

  • Evaluation of Clinical and Radiographic Outcomes, Assessment, and Complications of Ankle Fractures in Patients With and Without Diabetes
  • Pediatric Lateral Process of the Talus Fractures

George Liu, D.P.M.

  • Assessment of Radiographic Parameters and Clinical Outcomes in Foot and Ankle Trauma
  • Computed Tomographic (CT) and Radiographic Characterizations of the Human Tibiotalar Joint
  • Evaluation of Clinical and Radiographic Outcomes, Assessment, and Complications of Ankle Fractures in Patients With and Without Diabetes 

Drew Sanders, M.D.

  • A Retrospective Review of Complications Following Operative Fixation of Olecranon Fractures
  • Outcomes of Patella Fractures Treated by Tension Band vs. Cannulated Screw Fixation
  • Results of T-Bar External Fixation of Distal Tibia Fractures
  • Results of T-Bar External Fixation of Proximal Tibia Fractures
  • Tibia Shaft Fractures Treated with Intramedullary Nailing: Retrospective Review of Patients with and without Diabetes Mellitus

Ashoke Sathy, M.D.

  • Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (PAIN Study)
  • Streamlining Trauma Research Evaluation with Advanced Measurement (STREAM)
  • Use of Novel Tibial Traction Triangle for Reduction of Distal Tibia Shaft Fractures
  • Vertically Unstable Pelvic Fractures Fixed with Percutaneous Sacroiliac Screws: Does Trasiliac-transsacral placement Decrease Fixation Failure?

Timothy Schacherer, M.D.

  • Results of Revision Total Elbow Arthroplasty Requiring Massive Allograft-prosthesis Composite Reconstruction

Adam Starr, M.D.

  • A Retrospective Review of Conservative Management of Femoral Head Fractures
  • Complications Associated with Coronoid Fractures
  • Early Psychiatric Intervention After Orthopaedic Trauma: A Prospective, Randomized Double-Blinded Placebo Controlled Trial (PTSD)
  • Incidence of Coronal Plane Fractures after Traumatic Distal Femer Injuries
  • Major Extremity Trauma Research Consortium Registry (METRC)
  • Outcomes and Complications Following Achilles Tendon Ruptures
  • Pulmonary Embolism After Orthopaedic Trauma. A Retrospective Review (IVC Filter)
  • Sleep Disturbances in Patients with Orthopedic Pathology (Trauma)
  • A Model of In-hospital Mortality After Trauma in a Large Level 1 Trauma Center

Michael VanPelt, D.P.M.

  • Retrospective Review of Failure Rate of Fixation and Resubluxation of Lisfranc Fracture Dislocation
  • Retrospective Review of Patients Treated with Immediate Weight Bearing vs. Non-Weight Bearing after first Metatarsophalangeal Joint Arthrodesis. A Review of Fixation Failure, Infection, and Union.

Joel Wells, M.D.

  • Comprehensive Hip Questionnaire and Hip Registry
  • Comprehensive Knee Questionnaire and Knee Registry
  • Motion and Gait Analysis of the Pathologic Hip

Dane K. Wukich, M.D.

  • Comparing Health-related Quality of Life in Patients with Diabetic Foot Disorders Using SF-36 and PROMIS
  • Evaluation of Outcomes Following Foot and Ankle Fractures in Patients with Diabetes
  • Evaluation of Outcomes Following Orthopaedic Foot and Ankle Surgery Using the American College of Surgeons National Surgical Quality Improvement Program Database.
  • Identification of the most feared complications of diabetes in patients with diabetic foot related complaints.

Major Extremity Trauma Research Consortium Registry (METRC)

  • PAIN – Improving Pain Management and Long Term Outcomes following High Energy Orthopaedic Trauma (METRC)
  • FIXIT: Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fracture (METRC)
  • pTOG: RhBMP-2 vs. Autograft for Critical Size Tibial Defects: A multicenter, randomized trial (METRC)
  • STREAM
  • VANCO