Research in Molecular Genetics

Learn more about our faculty and their groundbreaking research:

Tenured Faculty

Joseph L. Goldstein, M.D.
SREBP (Sterol Regulatory Element Binding Protein) pathway regulation of cholesterol metabolism at the molecular, cellular, and whole-body levels. For more information about Dr. Goldstein’s research, visit the Brown/Goldstein Lab.

Michael S. Brown, M.D.
SREBP (Sterol Regulatory Element Binding Protein) pathway regulation of cholesterol metabolism at the molecular, cellular, and whole-body levels. For more information about Dr. Brown’s research, visit the Brown/Goldstein Lab.

Russell DeBose-Boyd, Ph.D.
Cholesterol homeostasis and HMG CoA reductase regulation. Please visit the Debose-Boyd Lab for more information.

Joachim Herz, M.D.
Molecular basis of Alzheimer’s disease and atherosclerosis. For more information about Dr. Herz’s research, visit the Herz Lab and the Center for Alzheimer’s and Neurodegenerative Diseases.

Helen H. Hobbs, M.D.
Defining the genetic determinants of plasma lipoprotein levels and cardiovascular risk. Please visit the Eugene McDermott Center for Human Growth and Development for more information.

Jay D. Horton, M.D.
How transcriptional regulators of cholesterol metabolism contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. Please visit the Horton Lab for more information.

Arun Radhakrishnan, Ph.D.
Protein-lipid interactions at membrane interfaces.

David Russell, Ph.D.
Enzymes that synthesize or break down different types of lipids and their roles in whole body lipid metabolism. Please visit the Russell Lab for more information.

Masashi Yanagisawa, M.D., Ph.D.
Molecular genetics of sleep/wake mechanisms.

Jin Ye, Ph.D.
Relationship of hepatitis C and cholesterol metabolism. Please visit the Ye Lab for more information.

Adjunct  Faculty

Sarah Comerford, Ph.D.
Maintenance of organ size in normal and cancerous states.

Murat Durakoglugil, M.D., Ph.D.

Y.K. (Yiu Kee) Ho, Ph.D.
Generation of mouse monoclonal antibodies against various proteins involved in cholesterol metabolism.

Guosheng Liang, Ph.D.
Dysregulation of lipid metabolism in diseases such as obesity, diabetes, and birth defects. Please visit the Liang Lab for more information.

Jeffrey G. McDonald, Ph.D.
Enzymes that synthesize or break down different types of lipids and their roles in whole body lipid metabolism.

Young-ah Moon, M.D., Ph.D.
Characterizing enzymes involved in microsomal fatty acid elongation and defining the potential roles the products of these enzymes have in regulating lipid homeostasis.