The major areas of technological advancement conducted at the Center include two applications of stable isotopes. Methods using 2H and 13C are under development to study metabolism in intact cells, animals and humans. Both of these isotopes can be applied simultaneously without interference for a more complete determination of metabolic fluxes. Learn more in Human Studies.
There is a need for both improved turn around of sample handling and the ability to extract as much information as possible from an experiment to analyze complex situations. Automated methods for reliable, consistent sample handling and spectral analysis are being developed, as are approaches to improve the sensitivity of the NMR experiment.
There is also much interest in the anatomical features of metabolism. New complexes that are sensitive to metabolites and the environment are showing great promise. These will provide a tool for understanding intra- and inter-organ aspects of metabolism.