Profile Details

Research Interest

Intracellular traffic in membrane proteins and lipids.
High-throughput screening of chemical compound libraries.
High-throughput screening of RNAi libraries.
Drug discovery

Faculty Research Bio

My laboratory is interested in the general problem of identifying small molecules that activate or inhibit specific biological functions and of identifying the molecular targets of such compounds. In particular we are interested in compounds that have more potent activity in cancer cells than normal cells and using them to identify the underlying molecular difference between these cellular states. We employ a number of techniques, including high-throughput screening of chemical compound libraries, to identify compounds of interest, as well as forward and reverse genetic approaches to identify the targets of compounds. Currently we have funded projects seeking to identify novel anti-viral mechanisms and drug leads, novel leads to anti-cancer therapeutics, and compounds that would eliminate the symptoms of diabetes.

Address

UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd
Dallas, Texas 75390

Contact:

214-648-3276

Recent Publications

Straud, S., I. O Zubovych, J. K. De Brabander and M. G. Roth , " Inhibition of Iron Uptake is Responsible for Differential Sensitivity to V-ATPase Inhibitors In Several Cancer Cell Lines "PLoS One ,5:e11629:doi:10.1371/journal.pone.0011629 ,2010

Zubovych, I., S. Straud and M. G. Roth , " Mitochondrial Dysfunction Confers Resistance to Multiple Drugs in Caenorhabditis elegans "Mol. Biol. Cell. ,21:556-569 ,2010

Chen, B., M. Dodge, W. Tang, J. Lu, Z. Ma, C-W. Fan, S. Wei, W. Hao, J. Kilgore, N. Williams, M. G. Roth, J. Amatruda, C. Chen and L. Lum , " Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer. "Nature Chem. Biol. ,5:100-107 ,2009

Rasko, D. A. C. G. Moreira, D. Li, J. M. Ritchie, M. K. Waldor, N. Williams, R. Taussig, C. Mischnoff2, S. Wei, M. G. Roth, D. T. Hughes, J. Huntley, J. R. Falck, and V. Sperandio , " Targetting QseC Signaling and Virulence for Antibiotic Development "Science ,321:1078-1080 ,2008

Tang, W., M. Dodge, D. Gundapaneni, C. Michnoff, M. G. Roth and L. Lum. , " A genome-wide RNAi screen for mammalian Wnt/beta-catenin pathway components identifies novel roles for TCF transcription factors in tumorigenesis. "Proc. Natl. Acad. Sci. USA. ,105:9709-9714 ,2008

Significant Publications

Chen, B., M. Dodge, W. Tang, J. Lu, Z. Ma, C-W. Fan, S. Wei, W. Hao, J. Kilgore, N. Williams, M. G. Roth, J. Amatruda, C. Chen and L. Lum , " Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer. "Nature Chem. Biol. ,5:100-107 ,2009

Whitehurst, A. W., B. O. Bodemann, J. Cardenas, D. Ferguson, L. Girard, M. Payton, J. D. Minna, C. Michnoff, W. Hao, M. G. Roth, X.-J. Xie, and M. A. White , " Synthetic Lethal Screen Identification of Chemosensitizer Loci in Cancer Cells. "Nature ,446:815-819 ,2007

Melkonian, K. A., A. G. Ostermeyer, J. Z. Chen, M. G. Roth, D. A. Brown. , " Role of lipid modifications in targeting proteins to detergent-resistant membrane domains: acylation can target proteins to the membranes, while prenylated proteins are excluded. "J. Biol. Chem. ,274:3910-3917 ,1999

Brewer, C. B. and M. G. Roth , " A single amino acid change in the cytoplasmic domain alters the polarized delivery of the influenza virus hemagglutinin. "J. Cell Biol. ,114:413-421 ,1991

Lazarovits, J., and M. G. Roth , " A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits. "Cell. ,53:743-752 ,1988