Awards for April 2013
Adinoff, Bryon, UT Dallas/NIH, Genetic and Environmental Modulators of Brain’s Response to Marijuana Cues, $7,950; Beutler, Bruce, Scripps Research Inst./NIH, Discovery and Analysis of Synthetic TLR Agonists and Antagonists, $258,297; Bibb, James, NIH, NMDA Receptor Regulation in Addiction, $286,200; Bruick, Richard, NIH, Study of Iron-Responsive E3 Ligase Regulating Mammalian Iron Homeostasis, $279,774; Burma, Sandeep, NASA, Mouse Glioma Models to Estimate Cancer Risks from HZE Particle Exposure, $450,000; Byerly, Matthew, Duke Univ. Med. Ctr., Comparison of Long-Acting Injectable Medications for Schizophrenia; ACLAIMS, $78,527; Byerly, Matthew, Columbia Univ./NIH, 2/2: Comparison of Long-Acting Injectable Medication for Schizophrenia (ACLAIMS), $5,242; Carroll, Thomas, NIH, Delineating a Role for Noncanonical Wnt Signaling in PKD, $330,426; Carson, Jo Ann, UNT HSC/NIH, Evaluating Community-Engaged Program to Reduce Obesity in Hispanic Families, $20,621.
Casey, Brian, George Washington Univ./NIH, Eunice Kennedy Schriver NICHD-MEFU Clinical Center Agreement - Capitation Payments, $231,152; Castro, Diana, Massachusetts Gen. Hosp./NIH, Spinal Muscular Atrophy (SMA) Biomarkers in Immediate Postnatal Period of Development (NN101), $19,413; Cleaver, Ondine, NIH, Blood Vessel Tubulogenesis: Rasip1-Directed GTPase Signaling and Cell Polarity, $357,750; Crandall, Craig, U.S. Dept. of Defense, Effects of Thermal Status on Markers of Blood Coagulation during Simulated Hemorrhage, $259,000; Cryer, Byron, NIH, Minority Predoctoral NLHBI Research Training at UT Southwestern, $106,527; Deberardinis, Ralph, Univ. of Cincinnati/NIH, Metabolic Adaptive Responses in Cancer, $13,700; Eisch, Amelia, NIH, Basic Science Training Program in Drug Abuse, $496,392; Elmquist, Joel (E. Berglund, Fellow), NIH, Regulation of Hepatic Substrate Flux by Leptin via POMC Neurons and Hepatocytes, $101,844.
Freeman, Anne, CDC, Capacity-Building Assistance (CBA) to Improve Delivery and Effectiveness of HIV Prevention Services, $258,394; Green, Carla, Univ. of Virginia/NIH, Analysis of New Circadian Mutant, $30,000; Greenberg, David, NIH, Novel Gene-Silencing Therapeutics for Multidrug-Resistant Gram-Negative Pathogens, $167,728; Hiesinger, Robin, NIH, Drosophila Model for Charcot-Marie-Tooth 2B Disease, $318,000; Hilgemann, Donald, NIH, Cardiac Function and PIP2, $339,560; Husain, Mustafa, NIH, Prolonging Remission in Depressed Elderly (PRIDE), $182,805; Husain, Mustafa, NIH, Prolonging Remission in Depressed Elderly (PRIDE) – Admin. Supplement, $25,125; Jiang, Jin, NIH, Complex Regulation of Ci-Gli Proteins in Hedgehog Signal Transduction, $307,665; Johnson, Jane, NIH, bHLH Transcription Factors in Neural Development, $304,088; Johnson, Mark, Yale Univ./NIH, Insulin Resistance Intervention after Stroke (IRIS) Trial, $306.
Journeycake, Janna, UT HSC/CDC, Public Health Surveillance for Prevention of Complications of Bleeding and Clotting Disorders, $20,190; Khera, Amit, Yale Univ./NIH, Young Women with Acute Myocardial Infarction (VIRGO), $30; Knudsen, Erik, NIH, Role of the RB Tumor Suppressor in Liver Tumorigenesis, $141,821; Koch, Joshua, Children’s Hosp. of Philadelphia/NIH, Impact of Hypothermia on Midazolam/Morphine Pharmacokinetics, $3,600; Konopka, Genevieve, NIH, FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions, $223,709; Konopka, Genevieve, NIH, FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions - Diversity Supplement, $49,878; Lee, William, Arkansas Children’s Hosp./NIH, Adduct Dipstick for Diagnosis of Acetaminophen Toxicity, $2,000; Leitch, Marilyn, Natl. Surgical and Adjuvant Breast and Bowel Project/NIH, STAR P-2 Trial Service Agreement, $578.
Lenkinski, Robert, NIH, PARACEST Agents: Optimization for Human MR Imaging, $790,456; Liu, Zhi-Ping, NIH, Epigenetic Regulation of Cardiac Hypertrophy and Heart Failure, $357,750; Lotan, Yair, UT M.D. Anderson/NIH, Aurora Kinase A as Biomarker for Detection of Bladder Cancer, $43,175; Maher, Elizabeth, NIH, Defining Metabolic Phenotype of Low-Grade Gliomas in Vivo, $148,466; Miller, David, Gynecologic Oncology Group/NIH, Gynecologic Oncology Group Studies (Per Capita), $3,000; Minna, John (A. Augustyn, Fellow), NIH, Defining Molecularly Distinct Subtype of Non-Small Cell Lung Cancer, $29,282; Mootha, Venkateswara, NIH, Genetics and Genomics of Fuchs Endothelial Corneal Dystrophy, $286,200; Nedzi, Lucien, American Coll. of Radiology/NIH, Radiation Therapy Oncology Group, $10,550; Nesbitt, Shawna, Minneapolis Med. Research Fndtn./NIH, ASPirin in Reducing Events in Elderly, $7,160.
Otwinowski, Zbyszek, NIH, Crystallography of Macromolecules, $288,303; Petroll, Matthew, NIH, Assessment of Corneal Fibroblast Biomechanical Behavior, $397,500; Rice, Luke, Natl. Science Fndtn., CAREER: Understanding Microtubule Dynamics Using Biochemically Defined Tubulin Mutants to Integrate Structure, Biochemistry, and Kinetics, $219,955; Rosen, Michael, NIH, Structural Study of GTPase Regulators and Effectors, $287,313; Rothenfluh, Adrian, NIH, Control of Alcohol Responses by Actin-Regulating Genes, $326,677; Sanchez, Pablo, RTI Intl./NIH, NICHD Neonatal Research Network Capitation Funding, $26,071; Schaffer, Joseph, RTI Intl./NIH, NICHD Pelvic Floor Disorders Network - Capitation Funding, $3,252; Schiller, Joan, Eastern Coop Oncology Group/NIH, ECOG Clinical Trials - Federal Payments, $2,000; Schmid, Sandra, NIH, Mechanisms Regulating Clathrin-Mediated Endocytosis, $377,306.
Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 1, $117,750; Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 2, $117,750; Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 3, $39,250; Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core B, $8,635; Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core D, $7,850; Shay, Jerry, Georgetown Univ./NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core A, $3,532; Shay, Jerry (A. Kaisani, Fellow), U.S. Dept. of Defense, Regulation of Angiogenesis by Homeobox Gene D10 (HoxD10) in Breast Cancer, $42,653.
Tamminga, Carol, NIH, Basic Science Training Program in Neurobiology of Mental Illness, $258,140; Vusirikala, Madhuri, Natl. Marrow Donor Program/NIH, RDSafe: Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life, $600; Wang, Serena, Jaeb Ctr. for Health Research/NIH, Pediatric Eye Disease Investigator Group: Amblyopia Treatment Study, $795; Womack, Kyle, Univ. of California, San Diego/NIH, ADNI-2: Alzheimer’s Disease Neuroimaging Initiative 2, $21,088; Wright, Tracey, Children’s Hosp. of Philadelphia/NIH, Evaluation and Treatment of Enthesitis, $2,000; Zhang, Rong, NIH, Arterial Aging, Brain Perfusion, and Exercise: Impact on Brain Structure and Function, $468,141; Zigman, Jeffrey, NIH, Role of Central Amygdala in Ghrelin-Mediated, Reward-Based Eating Behavior, $25,575; Zimmern, Philippe, New England Research Inst./NIH, Urinary Incontinence Treatment Network (UITN); Site 171, $5,320.
Bruick, Richard, Welch Fndtn., Analytical Approaches to Characterize Iron- and Oxygen-Sensing Mechanisms Governing Cellular Iron Homeostasis, $60,000; Burgess, Shawn, Welch Fndtn., Dysregulation of Intracellular Lipid Synthesis During Disease, $60,000; Chen, Zhijian, Welch Fndtn., Biochemical Mechanism of MAVS Activation by Prion-Like Polymerization, $100,000; Chiang, Cheng-Ming, Welch Fndtn., Mechanistic Action of BET Compound Inhibitors in Cancer Therapeutics, $60,000; Chuang, David, Welch Fndtn., Mitochondrial Signaling by Reversible Phosphorylation, $60,000; Conrad, Nicholas, Welch Fndtn., Biochemical Analysis of a Nuclear Poly(A)-Dependent RNA Decay Pathway, $60,000; Deberardinis, Ralph, Welch Fndtn., Glutamine-Dependent Reductive Carboxylation: A Metabolic Achilles’ Heel in Cancer, $100,000; Demartino, George, Welch Fndtn., Regulation of Proteasome Function by Reversible SUMOylation, $60,000.
Frohman, Elliot, Natl. Multiple Sclerosis Society, MS Clinical Fellowship 2013-14 (Sara Qureshi, Fellow), $65,000; Frohman, Elliot, New York Univ./Natl. Multiple Sclerosis Society, Mechanisms of Retinal Neurodegeneration and Visual Pathway Axonal Loss in MS, $48,038; Grishin, Nick, Welch Fndtn., Structure Mechanism of Circadian Clock-Mediated Transcription Activation, $75,000; Hibbs, Ryan, Welch Fndtn., Structural Basis of Chemical Transmitter Recognition by Pentameric Ligand-Gated Ion Channels, $60,000; Hiesinger, Robin, Welch Fndtn., Role of V0 ATPase in SNARE-mediated membrane fusion, $60,000; Horton, Jay, Fondation Leducq, Triglyceride Metabolism in Obesity and Cardiovascular Disease, $99,000; Hsieh, Jenny, Welch Fndtn., Chemical Regulation of Adult Hippocampal Neurogenesis and Memory, $75,000; Husain, Mustafa, Univ. of New South Wales, Controlled Trial of Transcranial Direct Current Stimulation as Treatment for Unipolar and Bipolar Depression, $18,073.
Jiang, Youxing, Welch Fndtn., Structural and Functional Studies of RCK-Regulated Potassium Channel, $100,000; Kavalali, Ege, Brain and Behavior Research Fndtn./NARSAD, Selective Suppression of Spontaneous Release and Fast-Acting Antidepressant Action, $100,000; Kittler, Ralf, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $489,628; Kraus, William (S. Gadad, Fellow), Susan G. Komen, Role of PARP-1 in Regulating Gene Expression in Breast Cancer Cells, $60,000; Lea, Jayanthi, Texas Tech Univ./CPRIT, SPOC-2011-001 PhI/II Trial of Fenretinide/LXS Oral Powder (NSC 374551) Plus Ketoconazole in Recurrent Ovarian and Primary Peritoneal Carcinoma, $25,000; Li, Wen-Hong, Juvenile Diabetes Research Fndtn., Biomarkers of Functional Beta Cells, $275,000; Lu, Richard, Natl. Multiple Sclerosis Society, Chromatin Remodeling in Oligodendrocyte Myelination and Remyelination, $34,375; Lum, Lawrence, Welch Fndtn., Modulation of Canonical Wnt Pathway Activity Using Small Molecules, $75,000.
Mahendroo, Mala, Burroughs Wellcome Fund, Dynamic Architecture of Cervical Collagen by SHG Endoscopy, $150,000; Mau, I-Fan Ted, Texas Christian Univ., Clinical Efficacy of Stretch-and-Flow Voice Therapy for Muscle Tension Dysphonia: Multicenter Randomized Clinical Trial, $16,395; Morrison, Sean (C. Meacham, Fellow), American Cancer Society, Functional Dissection of the Leukemia Cell Niche, $48,000; Pasare, Chandrashekhar, Welch Fndtn., Biochemical Role of IRAK-1 in Regulating Caspase-1 Activation and Cleavage, $60,000; Potts, Ryan, Welch Fndtn., Therapeutic Targeting of Melanoma Antigen (MAGE) Genes, $60,000; Rizo-Rey, Jose, Welch Fndtn., NMR Methods to Study Membrane Proteins in Lipid Bilayers, $75,000; Scherer, Philipp, Juvenile Diabetes Research Fndtn., Beta-Cytotrophic Actions on Islets, $250,000; Schiller, Joan, Eastern Coop Oncology Group/Frontier Science, ECOG Clinical Trials - Nonfederal Payments, $250.
Schmid, Sandra, Welch Fndtn., Conformational Dynamics and Regulation of Cynamin, $60,000; Scott, Daniel, Fndtn. for Surgical Fellowships, Bariatric and Minimally Invasive Surgery, $62,500; Sun, Xiankai, UT Dallas/CPRIT, Targeting Acidic Tumor Microenvironment for Cancer Imaging and Therapy: Renal Clearable and pH-Responsive Gold Nanoparticles, $156,587; Tambar, Uttam, Welch Fndtn., Stereoselective Allylic Functionalization of Olefins, $60,000; Tamminga, Carol (M. Robichaux, Fellow), Mclean Hosp./Simons Fndtn., Functional Analysis of Patient Mutations in EPHB2, an ASD Candidate Gene, $88,407; Terman, Jonathan, Welch Fndtn., Chemistry and Enzymology of MICAL Family Oxidoreductases, $75,000; Wan, Yihong, March of Dimes Fndtn., Maternal VLDLR Regulation of Milk PAFAH and Neonatal Inflammation, $122,360; Wan, Yihong, Welch Fndtn., Biochemical Characterization of PAFAH Regulation by Macrophage VLDLR, $75,000.
Wang, Zhigao, Welch Fndtn., Biochemical Identification of Proteases Involved in Necrotic Cell Death Execution, $60,000; Ward Ober, Sally, Natl. Multiple Sclerosis Society, Antigen Targeting and Tolerance in Murine EAE, $161,239; Westover, Kenneth, Welch Fndtn., Characterization of Covalent K-Ras Inhibitors, $60,000; White, Michael, Welch Fndtn., Analysis of Functional Significance of Complex Protein/Protein Interactions, $100,000; Yan, Nan, Welch Fndtn., Tail-Anchor of a Critical Innate Immunity Regulator TREX1 on the ER, $60,000; Ye, Jin, Welch Fndtn., Saturated Fatty Acid-Induced Lipotoxicity, $60,000; Yin, Helen, Howard Hughes Med. Inst., Mechanisms of Disease and Translational Science Graduate Program, $153,125; Zhang, Chengcheng, Welch Fndtn., Small Molecule Modulators of Angptl Receptor for Stem Cell Expansion and Leukemia Treatment, $60,000.
Industry-Sponsored Awards, Dollar Amounts not Available
Beg, Muhammad, Phase 1 Study of MRX34 IV in Patients with Advanced or Metastatic Cancer with Liver Involvement; Corey, David, Activation of Therapeutic Genes with Oligonucleotides; Gul, Fatma, BOTOX Treatment in Pediatric Upper Limb Spasticity: Study 101; Gul, Fatma, BOTOX Treatment in Pediatric Upper Limb Spasticity: Study 105; Gul, Fatma, BOTOX Treatment in Pediatric Upper Limb Spasticity: Study 111; Gul, Fatma, BOTOX Treatment in Pediatric Upper Limb Spasticity: Study 112; Gul, Fatma, BOTOX Treatment in Adult Patients with Post-Stroke Lower Limb Spasticity: Study 116; Jain, Raksha, Ph3 Study of Aztreonam Inhalation Solution (AZLI) for Treatment of Chronic Pulmonary Pseudomonas Aeruginosa Infection in Subjects with Cystic Fibrosis; Karp, David, Ph3/4 Study of Belimumab (HGS1006) in Adult Subjects of Black Race with Systemic Lupus Erythematosus (SLE); Lavery, Lawrence, Investigation of Use of Hyperspectral Imaging in Foot Surgery Patients.
Lingvay, Ildiko, Long-Term Trial to Evaluate Cardiovascular and Other Long-Term Outcomes with Semaglutide in Subjects with Type 2 Diabetes; Mao, Weihua, Evaluation of Geometric Calibration System, Isocal; Mao, Weihua, Precise Deformable Image Registration System; Mao, Weihua, Evaluation of Motion Compensation; Quigley, Raymond, Study of Cinacalcet HCl in Pediatric Subjects Age 28 Days to Less Than 6 Years with Chronic Kidney Disease and Secondary Hyperparathyroid; Raskin, Philip, Two Treatment Approaches for Human Regular U-500; Reimold, Andreas, Study of CNTO 136 (Sirukumab), Human Anti-IL-6 Monoclonal Antibody Administered Subcutaneously in Subjects with Active Rheumatoid Arthritis Despite DMARD Therapy; Sawant, Amit, Comprehensive Four-Dimensional Motion-Adaptive Lung SBRT; Schiller, Joan, Ph2 Study of Oral LDK378 in Crizotinin Naive Adult Patients with ALK-Activated Non-Small Cell Lung Cancer.
Vemulapalli, Roopa, Comparison of Capso Vision SV-1 to PillCam SB2 in Subjects with Suspected Small Bowel Disease; Wait, Michael, Ph3 Study of Intercostal Nerve Block with Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy; Wan, Yihong, RANKL Signaling in Cancer Bone Metastasis; Wu, Richard, Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patients with Atrial Fibrillation (Phase II/III) (Gloria AF).