July 2009 Grants

Federal grants 

Adinoff, B., NIH, Clinical Trials Network North Texas Node, $147,753; Adinoff, B., NIH, Stress, HPA Axis Dysfunction and Relapse in Alcoholism, $230,428; Albanesi, J., NIH/Univ. of Hawaii, Dynamin: Ligand Interactions and Conformational Dynamics, $58,260; Bibb, J., NIH, The Regulation of Dopamine Neurotransmission by CDK5, $43,500; Blount, P., NIH, Molecular Mechanisms of Mechanosensitive Channel Gating, $196,043.

Brugarolas, J., NIH, VEGF Regulation by the TSC2 Tumor Suppressor, $160,345; Bruick, R., NIH, Regulation of the Hypoxia-Inducible Factor, $155,117; Chiang, C., NIH, Regulation of P53 Transcription by Viral Oncoproteins and Covalent Modifications, $190,000; Chiang, C., NIH, E2-Cellular Complexes in HPV Chromatin Transcription, $180,187; Chuang, D., NIH, Structure and Function of Mitochondrial Protein Kinases, $240,000.

july-grants

Chuang, D., NIH, Inborn Errors of Metabolism in Cell Culture, $237,895; Cobb, M., NIH, Cell and Molecular Biology Training Program, $370,188; Crandall, C., NIH, Heat Stress and Circulatory Control, $270,613; Crandall, C., NASA/UT Arlington, Thermoregulatory Capacity and Exercise Response Following Prolonged Lunar Analog Bed Rest, $4,788; Cullum, M., NIH, Telecognitive Assessment Extending Neuropsychology to Underserved Elders, $164,000.

De Brabander, J., NIH, Chemistry and Biology of Antitumor Natural Products, $16,082; De Brabander, J., NIH, Chemistry and Biology of Antitumor Natural Products, $144,735; Eisch, A., NIH, Basic Science Training Program in Drug Abuse, $349,697; Eisch, A., NIH, New Horizons in Adult Neurogenesis, $88,014; Elmquist, J., NIH, CNS Pathways Regulating Ghrelin Effects on Body Weight, $222,500.

Elmquist, J., NIH, Central Mechanisms Regulating Energy Homeostasis, Project 2 of 10, $490,500; Elmquist, J., NIH, CNS Pathways Regulating Ghrelin Effects on Body Weight, $185,843; Emslie, G., NIH, Pediatric MDD: Sequential Treatment With Fluoxetine and Relapse Prevention CBT, $36,748 (Kennard, B., fellow); Falck, J., NIH/Med. Coll. of Wisc., $19,659; Garcia-Martinez, J.V., NIH, Nef Function, $260,185.

Garcia-Martinez, J.V., NIH, Nef Function, $57,300; Garcia-Martinez, J.V., NIH, Vaginal/Rectal HIV Transmission Model, $374,192; Gimpel, N., HRSA, Residency Training in Primary Care, $180,685; Graff, J., NIH, Adipocyte Development Lineage Analysis and Molecular Characterization, $250,000; Graff, J., NIH, Invertebrate Models of Fat Storage, $250,000.

Greene, R., NIH/McLean Hospital, Glutamatergic Dysfunction and Schizophrenia, $125,764; Halm, E., NIH, Long-Term Outcomes of Carotid Endarterectomy in the Elderly, $205,176; Halvorson, L., NIH, Pituitary PACAP Gene Regulation by Hypothalamic, Pituitary and Gonadal Factors, $162,680; Hendrixson, D., NIH, Campylobacter jejuni Flagellar Regulation and Synthesis, $21,432; Hofmann, S., NIH, Molecular Basis of Infantile NCL, $50,000.

Hughes, C., NIH, Exercise Treatment for Depressed Youth, $144,360; Igarashi, P., NIH, Regulation of Kidney-Specific Gene Expression, $195,073; Jain, M., NIH, Molecular Basis of Interferon Response in HCV, $115,000; Janowski, B., NIH, Molecular Switches: Regulatory RNAs Targeting Nuclear Hormone Receptor Promoters, $160,000; Jiang, Y., NIH, Molecular Basis of Ion Selectivity in the Prokaryotic Voltage-Gated Na Channel, $24,373 (Derebe, M., fellow).

Johnson, J., NIH, Regulation and Function of Ascl1 (Mash1) in Neural Development, $20,000; Karandikar, N., NIH, Role of T Cells in the Immune Modulation of MS, $20,000; Kernie, S., NIH/The University of Miami, Ephrins Regulate Stem Cell Proliferation Following TBI, $32,545; Kitchens, R., NIH, LPS Efflux from Host Cells to Plasma Lipoproteins, $18,603; Kowalske, K., U.S. Dept. of Ed., North Texas Burn Rehabilitation Model System, $287,698.

Lehrman, M., NIH, N-Glycosylation and ER Stress, $255,000; Levine, B., NIH, Infectious Diseases Training Program, $114,507; Levine, B., NSBRI/Baylor Coll. of Med., Impacts of Bed Rest, Exercise and Aging on Dynamic Starling Mechanisms, $55,556; Liu, K., NIH, The Role of Zfp296 in Controlling Autoimmunity, $50,000; Liu, Y., NIH, Post-transcriptional Regulation of the Neurospora Circadian Clock, $210,000.

Liu, Z., NIH, Role of FOXO4 in Atherosclerosis, $67,000; Livingston, E., NIH, Human Biology Core, Project 10 of 10, $269,300; Maalouf, N., NIH, Mentored Patient-Oriented Research Career Development, Award, $107,840; Mahendroo, M., NIH, Molecular Mechanisms of Parturition, $157,962; Mangelsdorf, D., NIH, Role of FGF21 as a Hormonal Mediator of PPARalpha Actions, Project 4 of 10, $245,250; Mason, R., NIH, UT Southwestern Small-Animal Imaging Resource, $15,250.

Mason, R., NIH, UT Southwestern Small-Animal Imaging Resource, $287,500; Mason, R., NIH/Tufts Univ., Fluorinated Cell Surfaces to Modulate Biological Function, $31,534; Medin, P., NIH, Spinal Cord Tolerance to Radiosurgical Dose Delivery, $22,454; Mohan, C., NIH, Immunogenetics of Antibody-Induced Nephritis, $220,000; Monteggia, L., NIH, MeCP2-Dependent Transcriptional Repression and Neurotransmission, $22,500.

Monteggia, L., NIH, Antidepressants and Intracellular Signaling Linked to BDNF, $151,709; Packer, M., NIH, North and Central Texas Clinical and Translational Science Initiative (UL1), $4,023,559; Packer, M., NIH, North and Central Texas Clinical and Translational Science Initiative (KL2), $765,864; Packer, M., NIH, North and Central Texas Clinical and Translational Science Initiative (TL1), $28,456; Petroll, W. M., NIH, A Novel 3-D Culture Model of the Anterior Cornea, $125,000.

Powell, C., NIH, Neuroligin Function In Vivo: Implications for Autism and Mental Retardation, $50,000; Rao, U., NIH, Treatment Prediction in Adolescent and Adult Depression, $213,341; Rothermel, B., NIH, Modulating Calcineurin Signaling Pathways in Muscle, $250,000; Savani, R., NIH, ABCA3 and the Response to Lung Injury, $10,000; Schiller, J., NIH/ECOG, ECOG Thoracic Committee, $7,698.

Self, D., NIH, VTA Ionotropic Glutamate Receptors in Cocaine Addiction, $231,483; Smith, L., NIH, Molecular Mechanisms of Neural Plasticity in Drug Addiction, $45,218; Soyombo-Shoola, A., NIH, Molecular and Functional Characterization of Mucolipin-1, $133,156; Sperandio, V., NIH, Regulation of EHEC Virulence Genes by QseA and Small RNA Molecules, $51,710 (Kendall, M., fellow); Story, M., NIH/UT Dallas, Gamma Globin Induction: Molecular and Cell-Based Strategies, $32,024.

Sun, X., DOD, Specific PET Imaging Probes for Early Detection of Prostate Cancer Metastases, $125,000; Tamminga, C., NIH, Antipsychotic Influence on Altered MTL Neuronal Activity in Schizophrenia, $250,000; Trivedi, J., NIH/Kansas Univ. Med. Ctr., Phase II Therapeutic Trial of Mexiletine, $21,930; van Oers, N., NIH, CD3 e Functions in T Cells, $250,000 (supplement); Varley, A., NIH, Interactions of Endotoxin With Plasma and Cells, $293,203.

Vitetta, E., NIH, Phase 1 Study of Safety and Immunogenicity of an Alum-Formulated Recombinant Ricin, $198,652; Wang, Z., NIH/Baylor Coll. of Med., Glucose and Lipid Metabolism in Obese Adolescents, $10,449; Wilkie, T., NIH, GQ/11-RGS Mediated Signaling, $189,918; Yarovinsky, F., NIH, Molecular Pathways Involved in TLR11-Mediated IL-12 Production by Dendritic Cells, $75,000; Yu, H., NIH, Protection of Centromeric Cohesion by Bub1 and Sgo1, $227,206; Zinn, A., NIH, Sim1 Function in Feeding Regulation, $240,000.

 
Nonfederal grants

Clegg, D., AHA, Hypothalamic Leptin Signaling Is Inhibited by Translocation of PKC-Theta: Predisposition to Metabolic Syndrome, $44,000 (Irani, B., fellow); Coppari, R., AHA, Suppression of Obesity-Induced NF-kB Inflammation in AgRP Neurons by Enhanced SIRT1 to Rescue Metabolic Homeostasis $42,000, (Ramadori, G., fellow); Elmquist, J., AHA, Cyclic AMP-Regulated Pathways Contribute to Central Leptin Resistance, $70,000 (Fukuda, M., fellow); Frohman, E., Natl. MS Soc., National MS Society Fellowship, $58,500 (Silversteen, J., fellow).

Frohman, E., Natl. MS Soc., MS Clinical Care Physician Fellowship, $58,500 (Graves, J., fellow); Ghayee, H., N. American Neuroendocrine Tumor Soc., mTOR Inhibitors Effect on Growth and Catecholamine Synthesis of Human Pheochromocytoma Cells, $45,454; Goldstein, J., Ara Parseghian Med. Research Fndtn., Research Fellowship-NPC2 Binding Cholesterol, $37,500 (Wang, M., fellow); Goldstein, J., Ara Parseghian Med. Research Fndtn., Research Fellowship-NPC, $37,500 (Abi-Mosleh, L., fellow).

Hsieh, J., Citizens United for Research in Epilepsy, Postnatal Neurogenesis as a Target for Epilepsy, $50,000; Li, B., AHA, Functional Dissection of Two Rpd3-Containing Histone Deacetylase Complexes, $63,600; Mammen, P., AHA, Cytoglobin Modulates the Fate and Viability of Cardiac Progenitor Cells Within the Stressed Heart, $63,637; Mangelsdorf, D., AHA, Appetite Control in C elegans, $70,000.

Mohan, C., Arthritis Fndtn., Molecular Genetics of Glomerular Crescent Formation, $50,000 (Du, Y., fellow); Olson, E., Life Science Research Fndtn., Characterization of STIM1 and Homer in Calcium Signaling, $56,000 (Huang, G., fellow); Ring, S., AHA, Effects of Preservation Solution Substrate Composition on Myocardial Metabolism During Machine Perfusion for Transplant, $63,636 (Jessen, M., fellow); Rosen, M., Cancer Research Fndtn., Inhibition and Activation Mechanisms of theWAVE Regulatory Complex, $46,500 (Chen, Z., fellow).

Shaul, P., AHA, Molecular Basis and In Vivo Implications of Nongenomic Estrogen-Receptor Alpha Function, $44,000 (Wu, Q., fellow); Sosie, D., AHA, Role of Twist in Homeostasis of Cardiac, $63,636; Stull, J., AHA, Role of ZIPK in the Heart, $42,000 (Chang, A., fellow); Tallquist, M., AHA, Analysis of PDGFR Alpha Signaling in Cardiac Fibroblast Development and Function, $25,000 (Smith, C., fellow); Zhang, C., AHA, Extrinsic Control of Cell Fates of Hematopoietic Stem Cells, $63,636. 

Pharmaceutical studies,
dollar amounts not available

Chin, K., A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study of Study Drug in Subjects With Pulmonary Arterial Hypertension; Chin, K., A Phase III, Multicenter, Open-Label Study to Evaluate the Long-Term Safety of Monotherapy Study Drug and Combination Therapy With Study Drug and Sildenafil Citrate in Subjects With Pulmonary Arterial Hypertension; Chin, K., A Phase III, Multicenter, Randomized, Double-Blind, Efficacy and Safety Study of Monotherapy Study Drug vs. Combination Therapy With Study Drug and Sildenafil Citrate in Subjects With Pulmonary Arterial Hypertension Who Have Completed Study B1321001.

Collins, R., A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Study Drug Treatment of Thrombocytopenia in Subjects With Low- or Intermediate-1-Risk Myelodysplastic Syndrome; Frohman, E., Modeling and Treating the Pathophysiology of Demyelination in MS; Guleserian, K., EXCOR® Pediatric Ventricular Assist Device (VAD).

Huth, J., A Double-Blind, Randomized, Placebo-Controlled Phase III Study to Assess the Efficacy of Study Drug Plus AS15 ASCI as Adjuvant Therapy in Patients With Drug-Positive Resected Stage III Melanoma; Jessen, M., The Effect of Acadesine on Clinically Significant Adverse Cardiovascular and Cerebrovascular Events in High-Risk Subjects Undergoing Coronary-Artery-Bypass-Graft Surgery Using Cardiopulmonary Bypass (Protocol No. P05633): Reduction in Cardiovascular Events by AcaDesine in Subjects Undergoing CABG) Limerick, M., and Sinclair, G., Human Immunodeficiency Virus-Acquired Lipodystrophy Classification, Measurement and Fat Response to a Drug Challenge in Differing Adult Phenotypic Presentations.

Raskin, P., A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of Study Drug vs. Placebo in Patients With Painful Diabetic Peripheral Neuropathy; Raskin, P., DEFEND-1: Durable-Response Therapy Evaluation For Early- or New-Onset Type 1 Diabetes; Rohrich, R., A Phase III, Multicenter, Randomized, Double-Blind, Parallel-Group, Active-Control Study to Evaluate The Safety and Efficacy of Local Administration of Study Drug for Prolonged Postoperative Analgesia in Subjects Undergoing Bilateral, Cosmetic Sub-Muscular Breast Augmentation.

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