Amyn Habib, MD

Assistant Professor
Neurology and Neurotherapeutics
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

amyn.habib@utsouthwestern.edu

Biography

I am interested in the diagnosis and treatment of brain tumors. I am also involved in basic scientific research trying to understand the biology of brain tumors and trying to identify ways to treat patients.

Education

Graduate SchoolDow Medical College - Pakistan (1986)

Research Interests

Growth factor signaling in cancer
The role of inflammation in gliomagenesis

Publications

Featured
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling.

Hognason T., Chatterjee S., Vartanian T., Ratan R. R., Ernewein K. M., and Habib A. A. , FEBS Letters , 2001; (491):9-15

The death domain containing kinase RIP1 regulates p27Kip 1 levels via a PI3K-Akt-Forkhead pathway

S Park, DB Ramnarain, KJ Hatanpaa, BE Mickey, D Saha, R Paulmurugan, CJ Madden, PS Wright, S Bhai, MA Ali, K Puttaparthi, W Hu, JL Elliott, O Stuve, and AA Habib , EMBO Reports , August 2008; (9):766-73

The receptor interacting protein inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen J, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, and Habib AA , Cancer Research , April 2009; (69):2809-2816

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and downregulation of PTEN

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, and Habib AA , Cancer Research , 2009; (69):4107-4111

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR

DB Ramnarain, R Paulmurugan, S Park, BE Mickey, A Asaithamby, D Saha, MA Kelliher, P Mukhopadhyay, F Banani, CJ Madden, PS Wright, S Chakravarty, and AA Habib , Cell Death and Differentiation , 2008; (15):344-353

Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells

Ramnarain DB, Park S, Lee DY, Hatanpaa KJ, Scoggin SO, Otu H, Libermann TA, Raisanen JM, Ashfaq R, Wong ET, Wu J, Elliott R, and Habib AA , Cancer Res. , 2006; (66 (2)):867-874

Honors/Awards

Clinical Investigator Award

National Cancer Institute (1999)