Shawn Burgess, PhD

Associate Professor
Advanced Imaging Research Center, Pharmacology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-2728
Office Fax: 214-645-2744

shawn.burgess@utsouthwestern.edu

Education

Graduate SchoolUniversity of Texas at Dallas, Chemistry (2000)
Graduate SchoolUniversity of Texas at Dallas, Chemistry (1997)

Research Interests

Biological NMR methods
In Vivo and Ex Vivo isotope tracer techniques
Intermediary metabolism: Elucidation of metabolic pathways
Metabolism in animal models of diabetes and obesity

Publications

Featured
Impaired Tricarboxylic Acid Cycle Activity in Mouse Livers Lacking Cytosolic Phosphoenolpyruvate Carboxykinase

Burgess SC, Hausler N, Merritt M, Jeffrey FMH, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, and Sherry AD. , Journal of Biological Chemistry , December 2004; (279):48941-48949

Featured
Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, and Finck BN , Journal of Biological Chemistry , December 2004; (281):19000-19008

Featured
Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse Liver

34. Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA , Cell Metabolism , April 2007; (5):313-320

Featured
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation

Pengxiang She, Shawn C. Burgess, Masakazu Shiota, Paul Flakoll, E Patrick Donahue, Craig R Malloy, A Dean Sherry, and Mark A Magnuson , Diabetes , 2003; (52):1649-1654

Featured
13C NMR Isotopomer Analysis Reveals a Connection Between Pyruvate Cycling and Glucose-Stimulated Insulin Secretion (GSIS)

Danhong Lu, Hindrik Mulder, Piyu Zhao, Shawn C Burgess, Mette V Jensen, Svetlana Kamzolova, Christopher B Newgard and A Dean Sherry , PNAS , 2002; (99):2708-2713

Partial Resistance to PPAR-alpha Agonists in ZDF Rats is Associated with Defective Hepatic Mitochondrial Metabolism

S. Satapati, TT. He, T. Inagaki, M. Potthoff, ME. Merritt, V. Esser, DJ. Mangelsdorf, SA Kliewer, JD. Browning and SC. Burgess , Diabetes , August 2008; (57):2012-2021

Regulation of the Fasting Response by PPARa-Mediated Induction of Fibroblast Growth Factor 21

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammad M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA , Cell Metabolism , 2007; (IN PRESS)

A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content. Hepatology

Browning JD, Davis J, Saboorian MH, and Burgess SC , Hepatology , 2006; (44):487-488

Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR

Natasha Hausler, Matthew Merritt, Charles Storey, Angela Milde, A. Dean Sherry Craig R. Malloy and SC Burgess , Biochemical Journal , 2006; (395):663

Comparison of 2H2O Measured Gluconeogenesis Determined by Both NMR and MS

Shawn C Burgess, Merrill Nuss, Bernard R Landau, A Dean Sherry and Craig R Malloy , Analytical Biochemistry , 2003; (318):321-324

Honors/Awards

ADA Basic Science Award

(2009)

American Diabetes Junior Faculty Award

(2005)

Professional Associations/Affiliations

American Chemical Society 1994-2000

American Diabetes Association 2003-

Center for Advanced Studies in Math and Nat. Sciences (CASMNS) advisory board Collin County Community College 2003-

International Society for Magnetic Resonance in Medicine