Joshua Mendell, MD, PhD

Professor
Molecular Biology
Graduate Program: Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-5183
Office Fax: 214-648-5190

joshua.mendell@utsouthwestern.edu

Education

Graduate SchoolJohns Hopkins University, Molecular Biology (2004)
Medical SchoolJohns Hopkins University, Medicine (2004)
UndergraduateCornell University, Biology (1996)

Research Interests

Cancer
MicroRNAs
Noncoding RNAs
Post-transcriptional Regulation

Publications

Featured
miRiad roles for the miR-17-92 cluster in development and disease

Mendell JT , Cell , 2008; (133 (2)):217-222

Featured
Widespread microRNA repression by Myc contributes to tumorigenesis

Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT , Nature Genetics , 2008; (40):43-50

Featured
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT , Molecular Cell , 2007; (26):745-752

Featured
A Hexanucleotide element directs microRNA nuclear import

Hwang HW, Wentzel EA, Mendell JT , Science , 2007; (315):97-100

Featured
c-Myc-regulated microRNAs modulate E2F1 expression

O’Donnell KA, Wentzel EA, Zeller KI, Dang CV, and Mendell JT , Nature , 2005; (435 (7043)):839-843

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, and Mendell JT , Genes and Development , December 2010; (24 (24)):2754-2759

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Chang TC, Zeitels LR, Hwang HW, Chivukula RR, Wentzel EA, Dews M, Jung J, Gao P, Dang CV, Beer MA, Thomas-Tikhonenko A, Mendell JT , PNAS , 2009; (106 (9)):3384-9

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model

Kota J, Chivukula RR, O?Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Clark KR, Mendell JR, Mendell JT , Cell , 2009; (137 (6)):1005-1017

Cell-cell contact globally activates microRNA biogenesis

Hwang HW, Wentzel EA, Mendell JT , PNAS , 2009; (106 (17)):7016-7021

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV , Nature , 2009; (458 (7239)):762-5

Honors/Awards

CPRIT Scholar in Cancer Research

(2011)

AACR Outstanding Achievement in Cancer Research Award

(2010)

Howard Hughes Medical Institute Early Career Scientist

(2009)

Allan C. Davis Medal

Outstanding Young Scientist in the State of Maryland (2007)

Rita Allen Foundation Scholar

(2006)