Mendell Lab:
RNA biology in health and disease


Regulation and function of noncoding RNAs

We employ a multi-disciplinary approach to interrogate the molecular functions of various classes of noncoding RNAs, including microRNAs and long noncoding RNAs.


Analysis of noncoding RNA functions in vivo

We use mouse models to investigate the roles of noncoding RNAs in normal physiology and in diseases such as cancer.


Genetic dissection of post-transcriptional regulatory pathways

We rely heavily upon genome-wide CRISPR screens and other high-throughput approaches to investigate post-transcriptional gene regulation and other aspects of RNA biology in mammalian cells.


The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

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