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Mendell Lab:
RNA biology in health and disease

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Regulation and function of noncoding RNAs

We employ a multi-disciplinary approach to interrogate the molecular functions of various classes of noncoding RNAs, including microRNAs and long noncoding RNAs.

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Analysis of noncoding RNA functions in vivo

We use mouse models to investigate the roles of noncoding RNAs in normal physiology and in diseases such as cancer.

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Genetic dissection of post-transcriptional regulatory pathways

We rely heavily upon genome-wide CRISPR screens and other high-throughput approaches to investigate post-transcriptional gene regulation and other aspects of RNA biology in mammalian cells.

Research

The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

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News/Publications

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Meet the Lab