Multivalent feedback regulation of HMG CoA reductase
Endoplasmic Reticulum Associated Degradation
Cell Regulation
RECENT PUBLICATIONS
Navdar Sever, Bao-Liang Song, Daisuke Yabe, Joseph L. Goldstein, Michael S. Brown, and Russell A. DeBose-Boyd, "Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl CoA reductase stimulated by sterols and geranylgeraniol" Journal of Biological Chemistry, 278:52479-52490, December 2003
Navdar Sever, Peter C.W. Lee, Bao-Liang Song, Robert B. Rawson, and Russell A. DeBose-Boyd, "Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl CoA reductase" Journal of Biological Chemistry, 279:43136-43147, December 2003
Russell A. DeBose-Boyd, "Knowing when to let go: endosomal release of LDL from the LDL-receptor" Molecular Cell, 16:160-162, October 2004
Peter C.W. Lee, Navdar Sever, and Russell A. DeBose-Boyd, "Isolation of sterol-resistant Chinese hamster ovary cells deficient in both Insig-1 and Insig-2" Journal of Biological Chemistry, 280:25242-25249, July 2005
SIGNIFICANT PUBLICATIONS
DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J., "Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi" Cell, 99:703-712, 1999
Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A, "Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain" Molecular Cell, 11:25-33, 2003
Bao-Liang Song and Russell A. DeBose-Boyd, "Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase" Journal of Biological Chemistry, 279:28798-28806, July 2004
Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd, "Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol" Cell Metabolism, 1:179-189, March 2005
Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd, "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase" Molecular Cell, 19:829-840, September 2005
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