Clinical Laboratory Services

The UTSW Clinical Laboratory Services (CLS) is a fully accredited facility offering a full range of clinical laboratory and anatomical pathology services, The Department of Pathology and Clinical Laboratory Services provides the principal medical diagnostic laboratory testing and transfusion functions for UTSW University Hospitals and Ambulatory Services. In addition, our laboratories serve as a referral laboratory to outside agencies, and support and participate in research and development appropriate to the needs of our institution.

Pathology and Clinical Laboratory Services set the standards for quality, lest methods, and procedures for laboratory testing for patient care in the medical center and supported clinics. Our mission is to provide timely, accurate, and convenient services for our patients.

The Pathology and Clinical Laboratory Services provides the following services for both inpatient and outpatient testing:

Anatomic and Surgical Pathology

Offers consultative services for those difficult and perplexing cases that invariably arise in every pathology practice, It also offers services in the subspecialties of pathology, including breast genitourinary, gynecological, gastrointestinal, bone, endocrine, head and neck, soft tissue, kidney, and ophthalmic pathology.


Provides constitutional and neoplastic cytogenetic analysis of blood, bone marrow, amniotic fluid, chorionic villus, solid tissue and tumor specimens using state of the art chromosome banding and molecular cytogenetic methods. A wide range of FISH (fluorescence in situ hybridization) probes is also available to detect acquired genetic aberrations in the cancer patient, as well as to diagnose microdeletion syndromes. In addition, the laboratory provides cell culture services for specialized metabolic and molecular testing.

Cytology/Image Analysis

Provides examination of cellular changes in gynecology and non-gynecology specimens.

Flow Cytometry

Provides immunophenotyping and immunodeficiency workup on specimens such as bone marrow, peripheral blood, cerebrospinal fluid, body fluid, tissues, etc. This laboratory section uses a dual laser technology which allows multi-color analysis of blood cells, aiding in the diagnoses of leukemia/lymphoma and the evaluation of immunological status.


Provides tissue processing services (tissue fixing, processing, embedding, sectioning, and staining).


Offers compatibility services for solid organ as well as Bone Marrow Transplant patients and donors. This laboratory section uses methodologies such as cytotoxicity and flow Cytometry, Luminex PRA and Single Antigen testing, Serological and Molecular HLA Typing.

Immunohistochemistry (IHC)

Provides a broad range of immunohistochemical stains for paraffin sections of fixed tissues, and selected in situ hybridization and immunofluorescence procedures.


Provides consultation on any bioptic specimen where hematolymphoid neoplasms are a diagnostic consideration. This laboratory section is intimately coordinated with the flow cytometry, immunohistochemistry, cytogenetics, and molecular diagnostics laboratories.


Offers comprehensive testing for detection, isolation, characterization and susceptibility testing of infectious agents. This laboratory section uses rapid direction detection methods where possible for optimal patient care, including immunologic and nucleic acid based assays.

Molecular Diagnostics

Using the cutting edge technology to provide assays for hematologic, infectious, and inherited disorders. The assay formats include liquid-phase hybridization, DNA sequencing, qualitative and quantitative PCR, and real-time quantitative PCR.


Provides a full range of clinical neuropathology consultation services including evaluation of brain biopsies, muscle and nerve biopsies, and autopsy brain specimens.

Seay Laboratory

Provides rapid laboratory testing for medical clinics located at Harold C. Simmons Comprehensive Cancer Center. This laboratory section performs a limited menu of tests such as electrolytes, blood cell counts, and coagulation times.

Specimen Procurement (Phlebotomy, Specimen Processing)

Provides phlebotomy services for inpatients of William P. Clements and Zale Lipshy University Hospitals and for outpatients of hospital clinics. This laboratory section also provides services such as receiving, triaging, and processing all blood and body fluid specimens.

Transfusion Services

Provides standard and specialized blood components for transfusion, compatibility testing for recipients, and diagnostic testing to evaluate immune hemolytic anemias, transfusion reactions, and alloimmunization to red cell, platelet, or white blood cell antigens.

University Hospital Core Labs

Combines specialty areas such as Clinical Chemistry, Coagulation, Hematology, Immunology, Point of Care Testing, and Urinalysis. The purpose is to provide routine and STAT laboratory testing for William P. Clements and Zale Lipshy University Hospitals.


Provides testing for the primary identification of a wide variety of viral infections (such as respiratory viruses, herpes viruses, enteroviruses, and many others), the monitoring of viral load in chronic disease (HIV, HCV, and HBV), and the quantitative assessment of viral infection/reactivation in transplant and other immunocompromised patients (CMV, EBV, and BK).