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Brown and Goldstein

Drs. Michael Brown and Joseph Goldstein met as young residents at Massachusetts General Hospital in 1966 and struck up a friendship—and eventually a scientific collaboration—that has brought the two to the pinnacle of science. Early in their career, they came across an astonishing case: Two very young siblings were having heart attacks and had extraordinarily high cholesterol. Years of painstaking research at UT Southwestern would find the cause.

Different in background and temperament yet similar in their devotion to science and discovery, Brown and Goldstein’s groundbreaking work has helped save millions of lives. And it has inspired the research and careers of succeeding generations of leading scientists. “It wasn’t necessary for us to impress the world. We were trying to impress each other,” says Mike Brown of his longtime partnership with Joe Goldstein. Learn their story.