In a surprise finding, UT Southwestern researchers report that lowering levels of the hormone leptin can reduce obesity, overeating, and the insulin resistance tied to diabetes – and they have found an antibody that can do that.

The new study focuses on leptin, a hormone produced by fat cells and sometimes referred to as a “lipostat” because of its presumed function to maintain body weight. It signals the brain to increase or decrease eating and exercise in response to weight gain or loss.

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