Chengcheng Zhang, PhD

Assistant Professor
Endowed Title: Michael L. Rosenberg Scholar in Medical Research 2006-2010
Physiology, Developmental Biology
Graduate Program: Immunology
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6000

alec.zhang@utsouthwestern.edu

Education

Graduate SchoolUniversity of Illinois Urbana Campus (1999)
Graduate SchoolChinese Academy of Sciences, Shanhai, China (1995)

Research Interests

Ex vivo expansion of HSCs for cell therapy and gene therapy
Interplay between stem cells and cancer
Interplay between stem cells and immunity
Mammary gland epithelial stem cells
Normal/leukemia stem cells and microenvironment

Publications

Featured
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation

Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BPC, Chen L, Zhang CC , Cell Stem Cell , 2011; (9):119-130

Featured
Metabolic Profiling Enriches for Hematopoietic Stem Cells

Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Olson EN, Schneider JW, Zhang CC*, Sadek HA* , Cell Stem Cell , 2010; (7):380-390

Featured
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

Zhang CC, Steele AD, Lindquist S, Lodish HF , Proc Natl Acad Sci U S A , 2006; (103):2184-2189

Featured
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells

Zhang CC, Kaba M, Ge G, Xie K, Tong W, Hug C, Lodish HF , Nature Medicine , 2006; (12):240-245

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation

Zheng J, Umikawa M, Zhang S, Huynh H, Silvany R, Chen BPC, Chen L, Zhang CC , Cell Stem Cell , 2011; (9):119-130

Angiopoietin-like protein 3 supports the activity of mouse hematopoietic stem cells in the bone marrow niche

Zheng J, Huynh H, Umikawa M, Silvany R, Zhang CC , Blood , 2011; (117):470-479

IGF Binding Protein 2 Supports the Survival and Cycling of Hematopoietic Stem Cells

Huynh H, Zheng J, Umikawa M, Zhang C, Silvany R, Iizuka S, Holzenberger M, Zhang W, Zhang CC , Blood , 2011; (118)

Metabolic Profiling Enriches for Hematopoietic Stem Cells

Simsek T, Kocabas F, Zheng J, DeBerardinis RJ, Olson EN, Schneider JW, Zhang CC*, Sadek HA* , Cell Stem Cell , 2010; (7):380-390

IGFBP2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells

Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish HF, Zhang CC , Stem Cells , 2008; (26):1628-1635

Honors/Awards

Gabrielle’s Angel Foundation for Cancer Research Fellow

(2009)

Basil O’Connor Scholar, March of Dimes Foundation

(2008)

American Society of Hematology Junior Faculty Scholar

(2007)

Howard Temin KO1 Award, National Cancer Institute

(2006)

Michael L. Rosenberg Scholar in Biomedical Research, UT Southwestern Medical Center

(2006)

Professional Associations/Affiliations

American Society for Cell Biology

American Society of Hematology

International Society for Stem Cell Research