Jun-Shen Huang, PhD

Assistant Professor
Cell Biology
Graduate Program: Cancer Biology
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2570
Office Fax: 214-648-8694

lily.huang@utsouthwestern.edu

Education

Graduate SchoolUniversity of California-San Diego (1997)

Research Interests

Cancer
Cytokine receptor
Hematopoiesis
Signal transduction
Structure-function analysis of protein

Publications

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

Michaely P., Zhao Z., Li W.P., Garuti R., Huang L.J., Hobbs H.H., Cohen J.C. , EMBO Journal , July 2007; (26(14)):3273-82

The Erythropoietic receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif.

Constantinescu N. S., Huang L.J., Nam H. S., and Lodish H. F. , Molecular Cell , February 2001; (7):377-385

The Membrane Proximal Region Of The Thrombopoietin Receptor (TpoR) Confers Its High Surface Expression by JAK2-dependent and independent mechanisms

Tong W, Sulahian R, Gross AW, Hendon N, Lodish HF, and Huang L.J. , Journal of Biological Chemistry , December 2006; (281(50)):38930-40

The N-terminal domain of Janus Kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

Huang L.J., Constantinescu N. S., and Lodish H. F. , Molecular Cell , December 2001; (8):1327-1338

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation via the receptor.

Flint-Ashtamker G., Eisen-Lev R., Cohen J., Huang L.J., and Newmann D. , 2002 , April 2002; (FEBS Letters 518 (1-3)):189-94

Honors/Awards

American Cancer Society Postdoctoral Fellowship

(2002)

Howard Temin Award

(2002)

NIH NRSA Award

(1998)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Society of Biochemistry and Molecular Biology