Lora Hooper, PhD

Associate Professor
Endowed Title: J. Wayne Streilein, M.D., Professorship in Immunology
Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell 2003-2007
Immunology, Cancer Immunobiology Center, Microbiology
Graduate Program: Immunology
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-7306
Office Fax: 214-648-7331

lora.hooper@utsouthwestern.edu

Education

Graduate SchoolWashington University (1996)

Research Interests

Carbohydrate-Lectin Interactions
Host-microbial interactions
Innate immunity
Mucosal immunology

Publications

Featured
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV, Science (New York, N.Y.), 2011 Oct; 334 (6053):255-8

Featured
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV, Proceedings of the National Academy of Sciences of the United States of America, 2011 May; 108 (21):8743-8

Featured
Molecular basis for peptidoglycan recognition by a bactericidal lectin.

Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV, Proceedings of the National Academy of Sciences of the United States of America, 2010 Apr; 107 (17):7722-7

Featured
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV, Proceedings of the National Academy of Sciences of the United States of America, 2008 Dec; 105 (52):20858-63

Featured
Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

Cash HL, Whitham CV, Behrendt CL, Hooper LV, Science (New York, N.Y.), 2006 Aug; 313 (5790):1126-30

You AhR What You Eat: Linking Diet and Immunity.

Hooper LV, Cell, 2011 Oct; 147 (3):489-91

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis.

Li XD, Chiu YH, Ismail AS, Behrendt CL, Wight-Carter M, Hooper LV, Chen ZJ, Proceedings of the National Academy of Sciences of the United States of America, 2011 Oct; 108 (42):17390-5

Intestinal microbiota promote enteric virus replication and systemic pathogenesis.

Kuss SK, Best GT, Etheredge CA, Pruijssers AJ, Frierson JM, Hooper LV, Dermody TS, Pfeiffer JK, Science (New York, N.Y.), 2011 Oct; 334 (6053)

Eat your carrots! T cells are RARing to go.

Vaishnava S, Hooper LV, Immunity, 2011 Mar; 34 (3):290-2

Immune adaptations that maintain homeostasis with the intestinal microbiota.

Hooper LV, Macpherson AJ, Nature reviews. Immunology, 2010 Mar; 10 (3):159-69

Honors/Awards

Howard Hughes Medical Institute

(2008)

Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease

(2007)

U.T. Southwestern Endowed Scholar in Biomedical Research

(2003)

Burroughs Wellcome Career Award in Biomedical Sciences

(2000)

Genzyme Award for Thesis Research in Glycobiology

(1996)