Gang Yu, PhD

Associate Professor
Endowed Title: Thomas O. Hicks Scholar in Medical Research 2001-2005
Neuroscience
Graduate Program: Cell Regulation
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1800
Office Fax: 214-648-1801

gang.yu@utsouthwestern.edu

Education

Graduate SchoolUniversity of Calgary - Canada (1996)
Graduate SchoolNorthwestern University (1991)
UndergraduateHangzhou Teacher's College (1988)

Research Interests

Alzheimer Disease
Frontotemporal Lobar Degeneration
The Gamma-Secretase Complex

Publications

Featured
Nicastrin Functions As A Gamma-Secretase-Substrate Receptor

Shah S, Lee S, Tabuchi K, Hao Y, Yu C, LaPlant Q, Ball H, Dann C, Sudhof T, and Yu G , Cell , August 2005; (122):435-447

Featured
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva et al. , Nature , 2000; (407):48-54

SorLA: Sorting Out APP.

Shah, S and Yu G , Mol. Interv. , 2006; (6):74-76

Presenilins Form ER Ca(2+) Leak Channels, a Function Disrupted by Familial Alzheimer’s Disease-Linked Mutations

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I , Cell , 2006; (126):981-993

Nicastrin Functions As A Gamma-Secretase-Substrate Receptor

Shah S, Lee S, Tabuchi K, Hao Y, Yu C, LaPlant Q, Ball H, Dann C, Sudhof T, and Yu G , Cell , 2005; (122):435-447

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G , J Biol Chem , 2004; (279):4144-52

Honors/Awards

Ruth Salta Junior Investigator Achievement Award

(2005)

Alzheimer Disease Research Award

(2003)

Natalie Ornish Award

(2002)

Thomas O. Hicks Scholar in Medical Research

U.T. Southwestern Endowed Scholar Award, 2001-2005 (2001)

Memorial Frist/Jus Research Award

(1998)

Professional Associations/Affiliations

Society for Neuroscience