Jin Jiang, PhD

Professor
Endowed Title: Eugene McDermott Scholar in Medical Research 1998-2002
Developmental Biology, Pharmacology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1951
Office Fax: 214-648-1960

jin.jiang@utsouthwestern.edu

Education

Graduate SchoolColumbia University in the City of New York (1992)
UndergraduateFudan University - China (1986)

Research Interests

Cell signaling pathways important for animal development and human diseases.
Genes and pathways involved in cell growth, differentiation, and pattern
Hedgehog and Wnt signal transduction pathways.
Tumor suppressor genes and mechanism of oncogenesis.

Publications

Featured
Hedgehog regulates Smoothened activity by inducing a conformational switch

Yun Zhao, Chao Tong, and Jin Jiang , Nature (article) , 2007; (450):252-258

Featured
Sgg/GSK-3 inhibits Hedgehog signaling by regulating Cubitus interruptus

Jianhang Jia, Kazuhito Amanai, Gelin Wang, Bing Wang, Jiong Tan, and Jin Jiang , Nature , 2002; (416):548-552

Featured
Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40 protein Slimb.

Jin Jiang and Gary Struhl. , Nature , 1998; (391):493-496

Featured
Complementary and mutually exclusive activities of Decapentaplegic and Wingless organize axial patterning during Drosophila leg development.

Jin Jiang and Gary Struhl , Cell , 1996; (86):401-409

Featured
Protein Kinase A and Hedgehog Signaling in Drosophila Limb Development.

Jin Jiang and Gary Struhl. , Cell , 1995; (80):563-572

Hedgehog regulates Smoothened activity by inducing a conformational switch

Yun Zhao, Chao Tong, and Jin Jiang , Nature (article) , November 2007; (450,):252-258

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, and Jin Jiang , Developmental Cell , March 2008; (14):377-387

A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor

Qing Zhang, Lei Zhang, Bing Wang, Chan-Yen Ou, Cheng-Ting Chien, and Jin Jiang. , Developmental Cell , June 2006; (10):719-729

Phosphorylation of Cubitus interruptus by Double-time/CKIbeta and CKIalpha targets it for Slimb/beta-TRCP mediated proteolytic processing

Jia, J., Ho, F., Tong, C., Zhang, Q., Wang, G., Wang, B., Amanai, K., and Jiang, J , Dev. Cell , 2005; (9):819-830

Hedgehog Signalling Activity of Smoothened Requires Phosphorylation by Protein Kinase A and Casein Kinase I

Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang , Nature , 2004; (432):1045-1050

Honors/Awards

Leukemia & Lymphoma Society Scholar Award

(2003)

Searle Scholar Award, the Chicago Community Trust

(1999)

Eugene McDermott Scholar in Biomedical Research, UT Southwestern

(1998)

Leukemia Society of America Special FellowLeukemia Society of America Special Fellow

(1998)

CUSBEA Fellow, Chinese Education Ministry

(1987)

Professional Associations/Affiliations

Genetic Society of America