Noelle Williams, PhD

Associate Professor
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

noelle.williams@utsouthwestern.edu

Education

Graduate SchoolUniversity of Virginia Main Campus, Microbiology (1996)
UndergraduateTrinity University, Biology (1990)

Research Interests

apoptosis and cell division
pharmacokinetics
small molecule therapeutics
toxicology

Publications

Featured
Targeting QseC signaling and virulence for antibiotic development

Rasko, DA, CG Moreira, DR Li, NC Reading, JM Ritchie, MK Waldor, N Williams, R Taussig, S Wei, M Roth, DT Hughes, JF Huntley, MW Fina, JR Falck, and V Sperandio , Science , August 2008; (321):1078-1080

Featured
Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM, Journal of the American Chemical Society, 2011 Feb; 133 (5):1428-37

Featured
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM, Nature chemical biology, 2011 ; 7 (10)

Featured
Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL, Cell, 2010 Jul; 142 (1):39-51

Featured
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C, Bioorganic & medicinal chemistry letters, 2009 Jul; 19 (14):3825-7

Featured
Therapeutic anti-cancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity

Williams, N.S., Burgett, A.W.G., Atkins, A.S., Wang, X., Harran, P.G., and McKnight, S.L. , Proc. Natl. Acad. Sci. USA , 2007; (104):2074-2079

Phase I dose escalation study with inrinotecan, capecitabine, epirubicin, and GCSF support for patients with solid malignancies

Becerra, C.R., U.N. Verma, H.T. Tran, D. Tavana, N.S. Williams, E.P. Frenkel , American Journal of Clinical Oncology , June 2008; (31):219-225

Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.

Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE, American journal of physiology. Cell physiology, 2011 Sep; 301 (3):C695-704

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L, Nature chemical biology, 2009 Feb; 5 (2):100-7

Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263.

Hunt DF, Henderson RA, Shabanowitz J, Sakaguchi K, Michel H, Sevilir N, Cox AL, Appella E, Engelhard VH, Journal of immunology (Baltimore, Md. : 1950), 2007 Sep; 179 (5)

Honors/Awards

Young Investigator Award

American Cancer Society/Simmons Cancer Center, UTSW (2002)

Individual National Research Service Award

National Cancer Institute (1998)

Postdoctoral Fellowship

Leukemia Research Foundation (1997)

Professional Associations/Affiliations

American Association for Cancer Research

American Association for the Advancement of Science

American Society for Pharmacology and Experimental Therapeutics