Andrew Zinn, MD, PhD

Associate Dean for the Medical Scientist Training Program
Professor
Eugene McDermott Center for Human Growth & Development, Internal Medicine
Graduate Program: Genetics and Development
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1615
Office Fax: 214-648-1666

andrew.zinn@utsouthwestern.edu

Education

Graduate SchoolUniversity of Texas Southwestern Med Ctr Dallas (1988)
Graduate SchoolUniversity of Texas Southwestern Med Ctr Dallas (1988)
UndergraduateUniversity of Texas at Austin, Liberal Arts (1981)

Research Interests

Chromosome abnormalities
Copy number variation
Obesity

Publications

Featured
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression

Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR* and Kublaoui BM* (*Equal contributors) , J Neurosci , 2010; (30):3083

Featured
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR , Mol Endocrinol , 2008; (22):1723-1734

Featured
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons

Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR , Mol Endocrinol , 2006; (20):2483-2492

Featured
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice

Holder Jr JL, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, and Zinn AR , Am J Phys Endocrinol Metab , 2004; (287):E105-13

Featured
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

Holder Jr. JL, Butte NF, Zinn AR , Hun Mol Gen , 2000; (9):101-108

Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression

Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR* and Kublaoui BM* (*Equal contributors). , J Neurosci , 2010; (30):3803

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR , Mol Endocrinol , 2008; (22):1723-1734

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.

Kublaoui BM, Holder JL Jr, Tolson KP, Gemelli T, Zinn AR , Endocrinology , 2006; (147):4542-4549

Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.

Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. , Mol Endocrinol , 2006; (20):2483-2492

Honors/Awards

Pfizer Scholar

(1994)

Damon Runyon-Walter Winchell Cancer Research Fund Fellowship

(1990-1993) (1990)

NIDDK Medical Resident Award

(1990)

Nominata Award for Outstanding Research, UT Southwestern

(1988)

Professional Associations/Affiliations

American Society for Human Genetics