Charles White, MD

Professor
Endowed Title: Nancy R. McCune Distinguished Chair in Alzheimer's Disease Research
Winspear Family Special Center for Research on the Neuropathology of Alzheimer's Disease
Pathology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2148
Office Fax: 214-648-6325

charles.white@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Charles L. White, III, M.D., is Professor of Pathology and has been the Director of the Division of Neuropathology at UT Southwestern since completing his residency and fellowship training in anatomic pathology and neuropathology at Johns Hopkins in 1983. Dr. White’s clinical and research interests focus on neurodegenerative brain disorders. He has been the director of the Neuropathology Core of the UT Southwestern Alzheimer Disease Center, funded by the National Institute on Aging, since its inception in 1988. He also directs the Winspear Family Center for Research on the Neuropathology of Alzheimer Disease, established at UT Southwestern in 2002 by a generous gift from the William and Margot Winspear Family. The Center invests in cutting-edge technology to pursue investigations of cytoskeletal defects and synaptic pathology in Alzheimer disease and related conditions, and also focuses on the translation of results of research studies into the development of clinical tests for patients with neurodegenerative disorders. Dr. White also serves as the faculty director of the Pathology Immunohistochemistry Laboratory, a core facility that provides a wide range of immunohistochemical staining services for campus physicians and investigators as well as for a number of off-campus clients and collaborators around the US for diagnostic and research studies. Dr. White is the Training Director for the Neuropathology Fellowship program at UT Southwestern, an ACGME-accredited, 2-year training program. Twelve trainees have completed the program and become board certified by the American Board of Pathology in the specialty of Neuropathology.  Dr. White is president-elect of the American Association of Neuropathologists; his term commences in 2012.

Education

InternshipJohns Hopkins School of Medicine (1983)
ResidencyJohns Hopkins School of Medicine (1981)
Medical SchoolUniversity of Arizona College of Med. (1978)

Research Interests

Alzheimer disease
Forensic neuropathology
Immunohistochemistry
Neurodegenerative disorders
Tissue microarray technology

Publications

Featured
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C , Proc Natl Acad Sci USA , October 1989; (86):7611-7615

Featured
The role of cortical connectivity in Alzheimer’s disease pathogenesis: a review and model system

de Lacoste MC, Whiet CL III , Neurobiol Aging , 1993; (14):1-16

Featured
Alzheimer’s disease: neurofibrillary tangles in nuclei that project to the cerebral cortex

German DC, White CL III, Sparkman DR , Neuroscience , 1987; (21):305-312

Featured
Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer type: possible role in cell loss

Saper CB, German DC, White CL III , Neurology , 1985; (35):1089-1095

Featured
Basal forebrain neurons in the dementia of Parkinson disease

Whitehouse PJ, Hedreen JC, White CL III, Price DL , Ann Neurol , 1983; (13):243-248

TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study

Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White CL III , J Neuropathol Exp Neurol , 2008; (67):271-279

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A , Hum Mutat , 2008; (29):512-521

Mutations in progranulin are a major cause of ubiqutin-positive frontotemporal lobar degeneration

Gass J, Cannon A, Mackenzie IR, et al. , Hum Mol Genet , 2006; (15):2988-3001

Alpha-synuclein expression in the developing human brain

Raghavan R, de Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL III , Pediatr Dev Pathol , 2004; (7):506-516

Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration.

Lipton AM, White CL III, Bigio EH , Acta Neuropathol , 2004; (108):379-385

Honors/Awards

Best Doctors in America, 2011-2012

(2011)

Best Doctors in America, 2009-2010

(2009)

Best Doctors in America: 2007-2008

(2007)

Best Doctors in America: 2005-2006

(2005)

Best Doctors in America: 2003-2004

(2003)

Manuscript of the Year Award, ASCP

(2001)

Phi Beta Kappa

(1975)

Professional Associations/Affiliations

American Association of Neuropathologists

American Society for Clinical Pathology

American Society for Investigative Pathology

Society for Neuroscience

The Histochemical Society